Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
Most people probably heard of the gene klotho by now.
Overexpression of klotho in mice leads to an increase in health and life expectancy.
Peat has also spoken favorably about it :
View: https://www.youtube.com/watch?v=OBKyKFCN_2E
I have previously posted about anti-aging benefits of T3 :
- T3 levels are a predictor of mortality from sepsis
- Thyroid hormone increases anti-oxidant enzymes, glucocorticoids lower them
Now this study adds another one to the ever expanding list:
This study shows that T3 increases klotho in C. elegans and has additional anti-aging benefits.
“...we found that at 50 lM T3 there was significant upregulation with increased expressions of both the genes. The fold of increase for C50F7.10 is 5.2-fold, whereas E02H9.5 increased by 2.4-fold compared to the respective untreated control group.”
Another anti-aging effect was a big reduction of lipofuscin :
“Our results showed that in comparison with their untreated counterpart, lipofuscin accumulation reduced significantly (- 42.5%; p \0.0001) in N2 worms when worms were grown in T3.”
Once again, T3 acts against oxidative stress:
“We also found that there was a significant reduction of intracellular ROS levels when worms were treated with T3 in both the age groups (- 70.82% in 3-days old & - 50.1% in 10-days old animals; p\ 0.0001)”
- Triiodothyronine (T3) enhances lifespan and protects against oxidative stress via activation of Klotho in Caenorhabditis elegans - Biogerontology
Overexpression of klotho in mice leads to an increase in health and life expectancy.
Peat has also spoken favorably about it :
View: https://www.youtube.com/watch?v=OBKyKFCN_2E
I have previously posted about anti-aging benefits of T3 :
- T3 levels are a predictor of mortality from sepsis
- Thyroid hormone increases anti-oxidant enzymes, glucocorticoids lower them
Now this study adds another one to the ever expanding list:
This study shows that T3 increases klotho in C. elegans and has additional anti-aging benefits.
“...we found that at 50 lM T3 there was significant upregulation with increased expressions of both the genes. The fold of increase for C50F7.10 is 5.2-fold, whereas E02H9.5 increased by 2.4-fold compared to the respective untreated control group.”
Another anti-aging effect was a big reduction of lipofuscin :
“Our results showed that in comparison with their untreated counterpart, lipofuscin accumulation reduced significantly (- 42.5%; p \0.0001) in N2 worms when worms were grown in T3.”
Once again, T3 acts against oxidative stress:
“We also found that there was a significant reduction of intracellular ROS levels when worms were treated with T3 in both the age groups (- 70.82% in 3-days old & - 50.1% in 10-days old animals; p\ 0.0001)”
- Triiodothyronine (T3) enhances lifespan and protects against oxidative stress via activation of Klotho in Caenorhabditis elegans - Biogerontology
