Some Luteolin benefits {neurons, hair loss, inflammation & repair, cancer, mast cell allergy reactions, more}

[cs3000]

Luteolin potentiates Nerve Growth Factor signalling for extra neuron regeneration / growth. so should be good in recovering from brain damage

Luteolin, a flavonoid in fruits and vegetables, has neurotrophic functions without a well-characterized mechanism. Here, we hypothesize a direct interaction of luteolin with nerve growth factor (NGF); as such, the functionality of the NGF could be potentiated. The direct binding of luteolin with NGF was validated by ultra-filtration, Biacore, and docking analyses. The result supports the development of luteolin as a therapeutic, or preventive, agent for NGF insufficiency-associated neurodegenerative diseases.

Luteolin stimulates the NGF-induced neurite outgrowth in cultured PC12 cells through binding with NGF and potentiating its receptor signaling

and crosses the Blood Brain Barrier well
Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury

<- free form reached high ng concentrations in the brain peaking at ~ 25mg-35mg human dose. different to rat study which was much lower in blood. kept inflammation / TNF-a low.

In summary, the present study demonstrated for the first time that luteolin can abolish AD-like features after TBI in an amyloid-β depositing mouse model. short term TBI accelerates Aβ pathology in the Tg2576 mouse model of AD and luteolin pretreatment ameliorates this effect

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Its a potent IL-10 inducer at low doses (anti-inflammatory, low in colitis) and helps macrophages express less M1 and more M2 (more repair, less inflammation)

https://www.researchgate.net/publication/348587280_Luteolin_Regulates_the_Differentiation_of_Regulatory_T_Cells_and_Activates_IL-10-Dependent_Macrophage_Polarization_against_Acute_Lung_Injury

^ here it worked at 0.2mg/kg I.P. so even low milligram doses orally should have good effect size

oral mucosa wound healing

https://web.archive.org/web/20221204150610id_/https://aip.scitation.org/doi/pdf/10.1063/5.0113495

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also slows cancer growth https://aacrjournals.org/cancerres/...lin-Promotes-Degradation-in-Signal-Transducer
(not estrogenic)

Although type II site ligands like luteolin do not bind to ERα or ERβ (21), they are anti-estrogenic in the rat uterus (1, 2, 7, 18). Only two genes (GTF2H2 and NCOA3) were affected by both estradiol and luteolin. Thus, the response of ESP genes to luteolin is specific and separate from genes regulated by estradiol in these cells.

& tumors even shrank by the end in the luteolin fed groups

At 4 weeks after the beginning of luteolin-containing food intake, the HAK-1B tumor volume began to decrease in a dosage-dependent manner. After 5 weeks of the dietary luteolin treatment, a significant decrease in tumor volume was found even in mice taking 50 ppm luteolin-containing food.

a potent apoptosis-inducing effect of luteolin (50 μmol/L) is shown in three hepatoma cell lines

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Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration

Hair loss affects millions of people at some time in their life, and safe and efficient treatments for hair loss are a significant unmet medical need. We report that topical delivery of quercetin (Que) stimulates resting hair follicles to grow with rapid ...

www.ncbi.nlm.nih.gov

assuming it works the same in humans, quercetin helps hair regrow substantially at "low" dose ~ 5mg

Luteolin (MOL000006), quercetin (MOL000098), kaempferol (MOL000422), baicalein (MOL002714), and beta-carotene (MOL002773) acted on 132, 54, 55, 35 and 18 targets, respectively. And the OB values of quercetin, luteolin, kaempferol, baicalein, and beta-carotene are 46.43%, 36.16%, 41.88%, 33.52%, and 37.18%, respectively
We selected top 3 active compounds (quercetin, luteolin, kaempferol) corresponding to core targets (AKT1, TP53, JUN, CASP3 and MYC)

Exploring the Mechanisms and Molecular Targets of Taohong Siwu Decoction for the Treatment of Androgenetic Alopecia Based on Network Analysis and Molecular Docking

Taohong Siwu decoction (THSWD) is traditionally used to treat androgenic alopecia (AGA) in clinical practice of traditional Chinese medicine. This study used a network pharmacology approach to elucidate the molecular mechanism governing the effect of ...

www.ncbi.nlm.nih.gov

Luteolin should work better for reversing hair loss / regrowth assuming the same mechanism works in humans.

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2 concerns:
- Does the anti growth effect on tumors apply to healthy cells? i read about igf-1 inhibition in tumors. does it hinder muscles?
https://www.sciencedirect.com/science/article/pii/S1756464621005259#s0065 <-- no , grip strength stayed the same for luteolin fed groups. & running time increased nicely

- 1 potential problem is it chelates iron and copper. copper pretty potently. i read a study where ceruloplasmin/copper was crashed by quercetin ~250mg daily which is similar compound

In the present study a decreased activity of Complex IV in mice treated with quercetin is clear. This is well correlated with decreased levels of ceruloplasmin
Our previous research [30] exposed that mild copper deprivation in mice is correlated with a decreased protein expression and activity of Complex IV at the level of OXPHOS supercomplexes along with a decrease in the ceruloplasmin levels.

Luteolin and quercetin possessing both (3-hydroxy)-5-hydroxy-4-keto and the catechol ring B were able to chelate 2 copper atoms per molecule similarly

^ so for long term use i wouldnt like to take more than low milligrams daily
but there is this https://file.scirp.org/pdf/PP20120400008_50818309.pdf , showing quercetin enhanced absorption from 1 big dose of minerals. quercetin is structurally similar.
(so they lower the mineral in body which enhances absorption of supplemented doses - giving a net boost if supplementing?)

theres ~5mg - 10mg per gram of dry camomile. and can be bought as supplement

 

[cs3000]

optimal dose for allergies (& likely other mast cell issues like hives rashes eczema, sometimes seen from covid or bacterial infection)
= 10mg/kg instead of 30mg/kg in mice (lower dose worked better)

Luteolin Attenuates Allergic Nasal Inflammation via Inhibition of Interleukin-4 in an Allergic Rhinitis Mouse Model and Peripheral Blood From Human Subjects With Allergic Rhinitis

Objectives: Luteolin is the active component of Perilla frutescens, an herb for the treatment of allergy in Asia. In this study, we aimed to investigate the effects and mechanisms of luteolin treatment.Methods: BALB/c mice sensitized with house dust mite ...

www.ncbi.nlm.nih.gov

(not clear on how i.p converts exactly, similar to oral but not the same,
orally would mean 10mg/kg or 50mg for a 60kg person works better than 150mg for cytokine reduction & sneeze/scratch reduction)


even works at very low dose, 0.1mg/kg i.p

Anti-allergic effect of luteolin in mice with allergic asthma and rhinitis

We aimed to evaluate the anti-allergic effect of luteolin treatment in mice with allergic asthma and rhinitis.Thirty-two BALB/c mice (n = 8 for each group) were used. Mice in group A (nonallergic group) were exposed to saline, while those in Group B (allergic ...

www.ncbi.nlm.nih.gov

potential role in MS through mast cells Mast Cells, T Cells, and Inhibition by Luteolin: Implications for the Pathogenesis and Treatment of Multiple Sclerosis
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Potent binding of covid protein by luteolin, which prevents it infecting cells Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase - Scientific Reports at single digit micromolar concentrations.
BUT by the looks of it concentration in blood in vivo orally does not reach that micromol level, stays nanomol. so probably not much of an effect directly

in rats and humans, this showed luteolin free form in plasma. https://core.ac.uk/download/pdf/82384138.pdf
14mg/kg ~150mg human orally gave 15 nanomol in blood (plus extra of conjugated forms)
so not enough for that covid binding effect,
other mice study showed near 1 micromol , so depending on which is closer to humans there might be some effect but
as it switches immune cells to anti inflammatory / repair mode - this one is probably best kept for the inflammatory stage of infections rather than early phase
Treatment of COVID-19 olfactory dysfunction with olfactory training, palmitoylethanolamide with luteolin, or combined therapy: a blinded controlled multicenter randomized trial here 70mg helped people restore their sense of smell, lost from covid

View: https://www.youtube.com/watch?v=CVLF2gYnTHw

did lower a different respiratory virus count at 50mg/kg i.p mice substantially Luteolin inhibits respiratory syncytial virus replication by regulating the MiR-155/SOCS1/STAT1 signaling pathway

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Luteolin ameliorates lipopolysaccharide-induced microcirculatory disturbance through inhibiting leukocyte adhesion in rat mesenteric venules

Microcirculatory disturbance is closely associated with multiple diseases such as ischemic and septic stroke. Luteolin (3,4,5,7-tetrahydroxyflavone) is a vascular protective flavonoid present in several dietary foods. However, how luteolin plays a role ...

www.ncbi.nlm.nih.gov

The results showed luteolin significantly inhibited LPS-induced leukocyte adhesion, hydrogen peroxide production and mast cell degranulation, and increased intestinal microcirculation blood flow and ameliorated pathological changes in the mesenteric artery and the small intestine.
Furthermore, luteolin inhibited the release of pro-inflammatory cytokines, the expression of TLR4, Myd88, ICAM-1, and VCAM-1, the phosphorylation of IκB-α and NF-κB/p65 in LPS stimulated EA.hy926.

The effect of luteolin on LPS-induced leukocyte adhesion to the rat mesenteric venular wall.

 

[Lokzo]

I take Artichoke extract every single day. One of my favourite, NOTICEABLE supplements.

 

[cs3000]

Luteolin reduces fear, anxiety, and depression in rats with post-traumatic stress disorder

https://www.tandfonline.com/doi/full/10.1080/19768354.2022.2104925

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cns.12648 1mg/kg orally autism model

https://www.researchgate.net/public..._hyperreactivity_in_ovalbumin_sensitized_mice low dose orally

oral mast cell dosing in mice

Luteolin promotes mitochondrial protection during acute and chronic periods of isoproterenol induced myocardial infarction in rats
heart / mitochondria protective low oral dose 0.3mg/kg , ~3mg - 4mg human dose (summary is a typo, helped restore mitochondrial enzymes)

 

[Mauritio]

Interesting thanks for sharing. @Hans just made a video on its anti-estrogenic effects.

it seems to increase monoamin uptake by increasing transporters. Unfortunetly it increases dopamine uptake more than serotonin.

Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt - PubMed

Monoamine transporters playing major roles in regulating normal and abnormal synaptic activity are associated with various neuropsychological disorders. In spite of the discovery of a series of structurally different monoamine transporter antagonists for the therapy approach, no practical...

pubmed.ncbi.nlm.nih.gov