Selegiline/Rasagiline

[Ron J]

Can someone share info about these substances?
How strong of a dopamine promoter is it compared to other substances like bromocriptine, cabergoline, lisuride, metergoline etc.? What are the side effects? Is heart valve problems a potential side effect?

 

[Ron J]

Anyone?

 

[TeslaFan]

It's unrelated to bromocriptine, lisuride, etc. Does not act on receptors, but blocks toxic degradation via MAO-B enzyme. Have you read basic info, like Wikipedia?

 

[Ron J]

Barely, but I did read some articles after. I still wish to know how it compares to the substances I mentioned, and other dopaminergic drugs. I'll try PubMed.
It's odd that there isn't much info about it in RPF.

 

[golder]

Does anyone know how rasagiline compares with selegiline?

 

[NewACC]

Does anyone know how rasagiline compares with selegiline?

Maybe rasalgine has stronger neuroprotective effect and doesn't have such metabolites like selegiline(Selegiline metabolise to L-deprenyl, L-methamphetamine and L-amphetamine, but as you know low doses of d-methamphetamine are pretty much neuroprotective)

 

[NewACC]

But there is in 130 times more potent that selegiline chemical, called (-)bpap. You can learn my post:
(-) Benzofuranylpropylaminopropan is unknown peaty chemical?