Has Anyone Stacked Cyproheptadine With A Potent Dopaminergic Drug?

[Ron J]

I think so.

I thought lisuride was one of those that may cause heart valve problems, but when I google searched 5-HT2B a study stated otherwise.

 

[Such_Saturation]

I thought lisuride was one of those that may cause heart valve problems, but when I google searched 5-HT2B a study stated otherwise.

I did that too

 

[DavePalumbo]

The perfect recipe for psychosis

 

[Dhair]

The perfect recipe for psychosis

Really? Then why are anti-serotonin drugs and GABA agonists used to treat psychosis and delirium?

 

[DavePalumbo]

Really? Then why are anti-serotonin drugs and GABA agonists used to treat psychosis and delirium?

Uhhhh.. don't be silly. How many serotonin receptors are there? 14? Only 1 receptor is targeted for psychosis and that's the 5ht2a receptor. This is obviously the main receptor for psychedelic drugs. New research suggests the 5ht3 receptor is also overactive in psychotic disorders.
Serotonin controls dopamine and other neurotransmitters in an inhibitory manner. If you antagonize the wrong serotonin receptors then you get psychosis from overactivity of dopamine receptors.
Underactivity of the metabotropic glutamate receptors 2/3 and inotropic nmda glutamate receptors can cause psychosis. The 5ht2a receptor lowers activity of mglur2/3 and this is a proposed mechanism for its induction of psychosis. Gaba-a also is inhibitory against mglur2/3 and the nmda receptor so this is a recipe for enormous disaster.

It's all very complicated. Some antipsychotic drugs like seroquel can paradoxically induce psychosis. So can risperidone. It's possible that they have some unknown mechanism for causing hallucinations but if not it just goes to show that neurotransmitters are very complex.

 

[Dhair]

Uhhhh.. don't be silly. How many serotonin receptors are there? 14? Only 1 receptor is targeted for psychosis and that's the 5ht2a receptor. This is obviously the main receptor for psychedelic drugs. New research suggests the 5ht3 receptor is also overactive in psychotic disorders.
Serotonin controls dopamine and other neurotransmitters in an inhibitory manner. If you antagonize the wrong serotonin receptors then you get psychosis from overactivity of dopamine receptors.
Underactivity of the metabotropic glutamate receptors 2/3 and inotropic nmda glutamate receptors can cause psychosis. The 5ht2a receptor lowers activity of mglur2/3 and this is a proposed mechanism for its induction of psychosis. Gaba-a also is inhibitory against mglur2/3 and the nmda receptor so this is a recipe for enormous disaster.

It's all very complicated. Some antipsychotic drugs like seroquel can paradoxically induce psychosis. So can risperidone. It's possible that they have some unknown mechanism for causing hallucinations but if not it just goes to show that neurotransmitters are very complex.

What are your thoughts on cyproheptadine being effective for schizophrenia?
In the schizophrenia trials with pregnenolone, progesterone was quite high in the patients after being treated. Peat thinks that most of pregnenolone's benefits are due to the downstream conversion of preg to progesterone, which is a potent GABA agonist.
So do you think a potent GABA agonist combined with an NMDA antagonist would precipitate a psychotic reaction? Many people on here seem to be combining adamantane with GABA agonists with some pretty good results. What are your thoughts on NMDA arangonism in general?

 

[DavePalumbo]

Keep in mind that not only is it the affinity of a drug for a receptor, it's also where in the brain it binds to receptors.
Valerian (herb) - Wikipedia
Baldrian (Valerian root) makes me slightly psychotic with hallucinations, it's a gaba-a agonist, but androgens, progesterone and other hormonal gaba-a agonists do not cause this issue. Why? First of all because of the different parts of the brain they work on.
Hormonal gaba-a agonists mainly target areas of the brain that have to do with emotions, so androgens blunt fear, depression and other emotional states as they're supposed to do.
How do androgens and other hormones become so specific in their receptor binding? Probably because they are metabolized from other hormones locally (in general). Who really knows, but it's definitely true that they act locally.

Why does cyproheptadine work in schizophrenia? Well, assuming it actually does (lots of antipsychotic drugs can cause psychosis but the psychiatrists hide this truth to prevent psychotic people from excusing themselves from taking the available treatments) it's probably because it lowers activity of multiple causes of psychosis with serotonin (5ht2a, 5ht3) and dopamine?

But take a look at the adverse reactions page on Wikipedia and you find that it can induce psychosis:
Cyproheptadine - Wikipedia

Nmda antagonism leads to hypersensitivity of dopamine, serotonin, opioidergic receptors and more, so that's at least 3 neurotransmitters causing psychosis via simply blocking the nmda receptor. Add in gaba-a agonists (that work in important brain regions) and you have a recipe for crazy-axe-wielding-man-kills-a-family-of-four-because-he-thought-they-were-controlling-his-mind.

Interestingly, overactivity of the nmda receptor also causes hypersensitivity of the 5ht2a receptor (this does not cause psychosis) which can lead to irritability, chronic fatigue, razing thoughts, affective flattening and other things seen in borderline personality disorder, Asperger's (potentially main mechanism) and other diseases.
This is why pregnenolone in lower dosages causes the fatigue, irritability, etc. If you are sensitive to nmda activation.. theanine will do the same in lower dosages.

Lots of people do brainless things. Some bear the consequences for their entire life in the form of permanent psychosis or brain damage, and others escape unharmed.

 

[Progesterone]

I’ve been using cypro and tyromix before bed and have been gaining all muscle and losing fat (not lifting weights). Libido is up and ed is non existent.

Are you still using these?

 

[Mauritio]

One could try cypro with Modafinil. Some sources say it works through Histamin some say Dopamin. I almost definitely get a dopamin feeling from it. I used to have a lot of allergies so i know what histamin feels like.
This is a drug that doesnt get enough recognition IMO . I have been using it for months ,especially on days when studying. Will try to combine it with Cypro.