Thanks, I would feel very bad if people were actually taking the phosphatidilycholine that I've seen available. Now if idealabs has a cheap source for DPPC, Ray Peat emailed this:haidut said:post 119063brandonk said:post 119044haidut said:post 118941 ...Taking phosphatidylcholine restores cardiolipin levels back to youthful levels ...
You are right, even though it does not say you should take PC it implies it. I will edit my post.
I think it must depend on the fats in the diet and the type of phosphatidilycholine. If DPPC were cheap, I’d try it, but most phosphatidylcholine is unsaturated and rancid.
Biochemistry (Mosc). 2010 Dec;75(12):1491-7.
Dietary supplementation of old rats with hydrogenated peanut oil restores
activities of mitochondrial respiratory complexes in skeletal muscles.
Bronnikov GE, Kulagina TP, Aripovsky AV.
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow
Region 142290, Russia. [email protected]
The effect of dietary supplementation of old rats (26-33 months) with
hydrogenated peanut oil on the activity of mitochondrial enzymes in skeletal
muscles has been studied. The activities of NADH-coenzyme Q1 oxidoreductase,
cytochrome c oxidase, and citrate synthase were determined spectrophotometrically
in muscle homogenates. The activities of respiratory complexes I and IV were
shown to significantly decrease with the age compared to the activity of the same
enzymes in young animals, while the activity of citrate synthase was virtually
unchanged. The fatty acid composition of muscle homogenates of old rats differed
from that of young animals by a reduced content of myristic, oleic, linoleic, and
α-linolenic acids and enhanced content of dihomo-γ-linolenic, arachidonic, and
docosahexaenoic acids. Per oral supplementation of the old rats with hydrogenated
peanut oil completely restored the activity of complex IV and increased the
activity of complex I to 80% of the value observed in muscles of young animals,
reducing the content of stearic, dihomo-γ-linolenic, arachidonic,
eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids relative to that in
the groups of old and young rats. The content of oleic and linoleic acids
increased relatively to that in the group of the old rats, as well as young
animals. The possible mechanisms of the restoration of the activity of the
respiratory enzymes under the administration of hydrogenated peanut oil are
discussed.
Bull Exp Biol Med. 2015 Jun;159(2):266-8.
Correction of Mitochondrial Enzyme Activities in the Skeletal Muscles of Old Rats
in Response to Addition of Olive Oil to the Ration.
Bronnikov GE(1), Kulagina TP, Aripovskii AV, Kramarova LI.
(1)Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow
Region, Russia, [email protected].
Activities of mitochondrial electron transport chain enzymes NADH-CoQ
oxidoreductase (complex I), cytochrome C-oxidase (complex IV), and citrate
synthase were measured by spectrophotometry in m. quadriceps femoris homogenate
from old rats receiving olive oil with the ration. Reduced activities of
complexes I and IV in old animals were restored to the level of young animals
after 6-week consumption of olive oil. Activity of citrate synthase did not
change with age. Positive effect of olive oil on fatty-acid composition of the
muscle tissue in old animals was demonstrated. The content of summary
monounsaturated fatty acids, reduced with aging, and of summary polyunsaturated
ones, increasing with age, were restored in old rats to the levels virtually not
differing from the levels of young animals.
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