Looking for help with PFS

[edoos]

Thanks for all your help and support guys, it's really appreciated. I'm going to try to focus on prolactin first with B6, Ginkgo and gen sing. I have seen they all have a quite good inhibiting property for prolactin. I was low in serotonin in a test I did 3 years ago I will focus on Dopamine if the lower prolactin do not make any improvement. Also, I would like to try HCG, but I'm from France and every doctor will look at me like I'm a martians. They are really not into that here in France.

 

[Unknownuser]

Since there is much talk about dopamine and prolactin in this thread, what about B6 (P5P)? Would that not be in the same league as l-dopa?

I use about 25-50mg p5p daily for almost 2 years now due to some other illness. My prolactine is very low. The problem with low prolactine is, it makes you ejaculate very quick. Sexually it's very frustrating. And low prolactine does not affect my libido at all. İt's still at zero.

 

[edoos]

I also ejaculate pretty quickly since PFS and have high prolactin

 

[MyUsernameHere]

The opposite here. Since PFS it sometimes took me 20-25 minutes (without porn). I had a very poor mental connection between brain and down there.
Recently it has improved so the average time is about half that.

I also stopped watching hardcore porn a long time ago, static images of women are enough for me

 

[Mister]

I also ejaculate pretty quickly since PFS and have high prolactin

Same.

Premature ejaculation is a very common PFS symptom.

 

[ChemHead]

The opposite here. Since PFS it sometimes took me 20-25 minutes (without porn). I had a very poor mental connection between brain and down there.
Recently it has improved so the average time is about half that.

I also stopped watching hardcore porn a long time ago, static images of women are enough for me

Agree. When I recovered from PFS, I ejaculated prematurely. However, since I was healed from finasteride, I could stay hard and just continue going so I guess that was a plus.

 

[MyUsernameHere]

I'll be taking 300 mg of P5P split into 3 doses. How will I know if it's doing anything for my prolactin? I don't feel much thus far (started this morning).

 

[Unknownuser]

300mg is way too much. You sure it's p5p? If it's normal b6 300mg is ok. But p5p can become toxic at high doses as much as I know.

 

[Charger]

I'll be taking 300 mg of P5P split into 3 doses. How will I know if it's doing anything for my prolactin? I don't feel much thus far (started this morning).

High dopamine/low prolactin basically just feels like you're mentally clear and present, in my experience. Extremely low prolactin from something like Cabergoline makes me feel so stimulated I can hardly think, it's not exactly desirable to crash your prolactin.

I will quote again what I said about high dose b6... I don't recommend it in high doses for long.

It is good for prolactin, however, I used high doses (300mg/d) that were comparable in effectiveness to cabergoline and I ended up having an acne breakout on my right bicep.

I still use B6, it just comes in whatever amount is in the Monster energy drinks I have everyday.

 

[Unknownuser]

I was in pharma and they only have l dopa that contains other stuff as well.

- Levodopa
- carbidopa
- Entacapon

Is that really safe to take? Or can it cause some more brain damage?

 

[Charger]

If you want to keep prolactin low, dopamine high, then ginkgo, forskolin, niacinamide, 5a-dhp, caffeine, t3 are all safe options that can be taken daily.

I brought my prolactin from 17 down to 10 ng/mL with these supplements.

 

[ChemHead]

I was in pharma and they only have l dopa that contains other stuff as well.

- Levodopa
- carbidopa
- Entacapon

Is that really safe to take? Or can it cause some more brain damage?

Carbidopa encourages the decarboxylation of l-dopa which essentially prevents it from becoming dopamine. However, carbidopa can't cross into the brain while l-dopa can. This means that carbidopa will deactivate l-dopa in the body, but not in the brain. So, carbidopa essentially ensures that you're not getting side effects of l-dopa from peripheral dopamine.

Entacapon is apparently supposed to make the effects of dopamine last longer in the brain. I haven't really looked much into Entacapon much so not a whole lot of information I can give. So, this cocktail is tailored for Parkinson sufferers.

If I were going to use this, I would probably start with a much lower dose because I'm not sure how Entacapon would affect dopaminergic activity.

 

[Unknownuser]

Carbidopa encourages the decarboxylation of l-dopa which essentially prevents it from becoming dopamine. However, carbidopa can't cross into the brain while l-dopa can. This means that carbidopa will deactivate l-dopa in the body, but not in the brain. So, carbidopa essentially ensures that you're not getting side effects of l-dopa from peripheral dopamine.

Entacapon is apparently supposed to make the effects of dopamine last longer in the brain. I haven't really looked much into Entacapon much so not a whole lot of information I can give. So, this cocktail is tailored for Parkinson sufferers.

If I were going to use this, I would probably start with a much lower dose because I'm not sure how Entacapon would affect dopaminergic activity.

Interesting, thanks!

I just found this on a German website. It's google translated.

Vitamin B6: to be considered during pregnancy, breastfeeding and medication use
During pregnancy and breastfeeding, women should only take high-dose vitamin B6 if there is a proven deficiency and in consultation with a doctor.

In high doses, vitamin B6 weakens the effect of drugs in epilepsy and Parkinson's disease. Therefore, vitamin B6 should not be consumed more than 5 milligrams per day when using these drugs:

Epilepsy medication (anti-epileptic): phenobarbital (Luminal®) and phenytoin (Phenhydan®, Zentropil®)
Parkinson's medication: L-Dopa (levodopa) such as Levopar®, Madopar®, Duodopa® and Stalevo®

 

[ChemHead]

Looks like Entacapon is an enzyme antagonist. It's an inhibitor of catechol-O-methyltransferase. So, it prevents dopamine from being metabolized and deactivated.

To me this means you can probably use a lot less to get the same effect and since you're inhibiting catechol-O-methyltransferase, you're also preventing the formation of toxic aldehydes since dopamine can't be metabolized.

If you were to try this, I would be very careful with the dose since this will cause a much more potent effect in the brain. Keep the dose very low and work your way up.

 

[Unknownuser]

Looks like Entacapon is an enzyme antagonist. It's an inhibitor of catechol-O-methyltransferase. So, it prevents dopamine from being metabolized and deactivated.

To me this means you can probably use a lot less to get the same effect and since you're inhibiting catechol-O-methyltransferase, you're also preventing the formation of toxic aldehydes since dopamine can't be metabolized.

If you were to try this, I would be very careful with the dose since this will cause a much more potent effect in the brain. Keep the dose very low and work your way up.

Will take it as a last effort. What about uridine? Tried it? I read on the pfs forum that it worked for some people. But just like bpc 157, only few days. And then the effect stops. I really wonder why that happens with almost any supplement.

How to Repair Dopamine Receptors Naturally - 10 Ways to Upregulate

When people reference "boosting dopamine," they usually mean repairing or "upregulating" the receptors involved in the dopamine reward pathway.

www.theoptimizingblog.com

 

[Charger]

I've used Uridine, it's a good supplement, will make you feel emotionally flat/robotic in high doses.

 

[Unknownuser]

I've used Uridine, it's a good supplement, will make you feel emotionally flat/robotic in high doses.

I feel like that already ?
I take 250mg citocholine and a b-complex for a week now without any effect so far.

Took 25mcg T3 today and feel anxious and also aggressive right now. But took lots of other new ***t today as well so I dont know whats causing it.

My FT3 is on the upper end already so I guess T3 is not for me.

 

[Charger]

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[Charger]

Aggression could be excess dopamine, cortisol, or adrenaline.

The point with T3 is to lower TSH below 1, lower prolactin, cortisol, and increase DHT. It doesn't make me feel aggressive, it makes me feel mentally clear, calm, and alert. T3 needs time to work, you don't just take it for a day or two. It initially spiked my appetite, but that has normalized.

What other supplements did you start taking?

 

[MyUsernameHere]

300mg is way too much. You sure it's p5p? If it's normal b6 300mg is ok. But p5p can become toxic at high doses as much as I know.

(PDF) The Role of Vitamin B6 in Reducing Serum Prolactin in Comparison to Cabergoline

PDF | Hyperprolactinemia is a common endocrine disorder of hypothalamic-pituitary axis. It affect about 4-17% of women in reproductive age and about... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

OK yeah, this study says 200 mg is the top, so I guess I'll take that split into two doses. I don't plan on taking it for a very long time. Maybe a week tops, just to see if lowering prolactin actually impacts any of my symptoms in a meaningful way.