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WOW!It has been known since ancient Greek times that during pregnancy skin color in women changes drastically. Doctors have long suspected that hormones are involved but until now the mechanism was not known. This study shows that estrogen and progesterone are involved in skin color changes. Estrogen increases the production of melanocytes and causes skin to darken, while progesterone works in the opposite direction and lightens skin color. While it would be premature to say that estrogen directly causes melanoma (even though I suspect it) the increased and uncontrolled production of melanocytes is a necessary condition for melanoma to develop and it seems that estrogen is a primary driver of that process, while progesterone opposes it. I posted another study recently showing that pregnenolone is another hormone that may be effective in stopping melanoma progression directly and its conversion into progesterone is likely to have additive beneficial effect.
Pregnenolone For Protection Against Melanoma
Peat also wrote in one of his articles how he made his "active melanomas" disappear by rubbing progesterone and DHEA on them and this study seems to back up his approach.
Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors. - PubMed - NCBI
Penn Medicine study uncovers new pathways that control skin tanning and lightening | Science Codex
Scientists Find New Way to Tan or Lighten Skin
"...Researchers found that skin color can be regulated by estrogen and progesterone, two of the main female sex hormones. Estrogen darkens the skin; progesterone lightens the skin. Although this much was known to a limited degree, the new research revealed two cellular receptors that appear to control this process in skin cells called melanocytes."
"...By studying human skin cells both in a petri dish and in a 3D-bioengineered patch of skin about the size of a postage stamp, Ridky's team discovered a different, unexpected set of receptors on melanocytes that do interact with the sex hormones. Specifically, they found a receptor called GPER that interacts with estrogen and triggers melanin production, and a receptor called PAQR7 that interacts with progesterone and decreases melanin production."
I'm blown away by this For how much and how long should we humans tan?Sun exposure increases production of melanin thereby increasing estrogen in the process
This is what melanotan does. Mimick MSH. So melanotan increases "production of melanin thereby increasing estrogen in the process"?
Me tooI always thought that vitamin D from the sun lowers estrogen.
Does melanin increase estrogen regardless of how much PUFA is in the body?Also, sunlight and its UV portion is only dangerous when there is a lot of tissue PUFA, and in that case taking aspirin/niacinamide before going into the sun should mitigate the damage.
What do you think, is endogenous Melanin production a protective response to inflammation or tissue-damage caused by radiation, estrogens etc. or is it in itself
a destructive process?
Also, Thymoquinone seems to offer promisinf properties, could it be a "Peat approved" Quinone/Phytochemical?
Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review. - PubMed - NCBI
I do notice that people from hotter climates and darker skin tend to be more loud and aggressive. Even with Caucasians like sicilians Greeks Turks Lebanese Persians ect. Look more masculine and r more aggressive than lets say a German or Dutch or british person..
I always thought that vitamin D from the sun lowers estrogen. That's y people from the tropics are more lean and have better skin and hairlines usually than people who like in cloudy cold climates.