themartian1000
Member
- Joined
- Jun 28, 2021
- Messages
- 96
I am curious if anyone knows if topical progesterone such as progestene reaches the brain? I know that progesterone in the brain converts to allopregnanolone and may also be a calcium channel blocker, both of which reduce neural excitation. I know this occurs rapidly with oral progesterone, but levels are supratherapeutic and also uneven, which is not very physiologic.
I have optimized all that I can (diet, thyroid etc), but as a perimenopausal 48 year old women, have progesterone that is not optimal. I also have anxiety and insomnia. These are all much better with oral progesterone like prometrium (Progest-E for some reason doesn't quite do it for me, perhaps the dose). I am considering trying topical progestene to see if I can can stable brain levels and curious what people think.
I have optimized all that I can (diet, thyroid etc), but as a perimenopausal 48 year old women, have progesterone that is not optimal. I also have anxiety and insomnia. These are all much better with oral progesterone like prometrium (Progest-E for some reason doesn't quite do it for me, perhaps the dose). I am considering trying topical progestene to see if I can can stable brain levels and curious what people think.