Yes.Caffeinated coffee does not acutely affect energy intake, appetite, or inflammation but prevents serum cortisol concentrations from falling in healthy men.
10.3945/jn.110.137323
Maybe by quitting coffee my knees are stiff because I don't have the same amount of cortisol circulating.
Testosterone on its own makes my joints very achy and wakes up pains that had long been gone. Because testosterone in high doses completely anihilates cortisol.
Adding pregnenolone makes those pains disappear in 24 hours.