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The first line of defense in prostate cancer is androgen depravation with drugs that lower testosterone. PSA is a marker and when it starts to rise the second line is an androgen receptor blocker. Prostate cancer will eventually mutate and produce a AR variant that does not allow the androgen blocker to bind to the ligand. I now have this variant called AR-V7. Reading Pub med studies I find that Niclosamide and Berberbine can block this variant and allow Zytiga to work. Niclosimide is hard to get (I hard to order from Thailand). So lets see if this works as my PSA is still very high.
https://www.researchgate.net/publication/51166087_Berberine_Suppresses_Androgen_Receptor_Signaling_in_Prostate_Cancer
Berberine inhibits androgen synthesis by interaction with aldo-keto reductase 1C3 in 22Rv1 prostate cancer cells Tian Y, Zhao L, Wang Y, Zhang H, Xu D, Zhao X, Li Y, Li J - Asian J Androl
Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration resistant prostate cancer
Jane Mclelland said in one of her interviews that Prostate Cancer is one of the very few cancers that does very well on a Dean Ornish type diet with “no fat” at all. A friend of hers dropped his PSA doing that such diet.
Are you taking berberine ? .. I purchased a bottle from vitamin shoppe and have yet to start it. I’m a little weary of supplements. But this study is the reason I purchased it.
Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway
I was using a cheaper berberine supplement that was not working. I switched to Thorne and noticed a big difference.
I now have this variant called AR-V7. Reading Pub med studies I find that Niclosamide and Berberbine can block this variant and allow Zytiga to work. Niclosimide is hard to get (I hard to order from Thailand). So lets see if this works as my PSA is still very high.
How are you doing @Oraganic4me ?I wanted to say thanks to you. I was diagnosed in 2014 with stage 2-b colon cancer they told me surgery cured me and to go enjoy life. Then in 2016 It spread and I was stage 4 with metastasis to both lobes of my liver and gallbladder. After surgery and chemo, I tried Keto, then Vegan (China Study) but not feeling the euphoria these diets promoted... went to Endocrinologist because GP found nodules on my thyroid. They put me on 50 levothyroxine , That is how I discovered Ray Peat. I am trying to balance my hormones naturally. I am incorporating some of his ideas and feeling great but , when you mentioned Jane Mclelland on another post, I looked her up and I just ordered her book. I am very interested to see what she and Dr Peat agree on ,
Thank you again for mentioning her , I never heard of her.