David PS
Member
Hyaluronan/hyaluronic acid (HA) is a biologically important polysaccharide molecule found in the animal kingdom, most notably in the extracellular matrix (ECM)of connective tissues and on the surface of certain pathogenic bacteria. Although HA is found in nearly every tissue of vertebrates, it is abundantly present in the extracellular matrix of soft connective tissues. In mammals, it’s predominantly found in the connective tissue of skin, testes, umbilical cord and synovial fluid.
The skin care industry and the supplement industry are selling HA products to replenish the levels of HA that naturally decline with age. Mostly, to reduce wrinkles and create a more youthful appearance and also increase health span. Years ago, Connie Chung was in an ABC News interview/infomercial on the miracle of HA that may have launched the HA industry in the US. I think that the infomercial is worth watching. The marketing wizards who brought us this 'ABC News' story suggest that the long health span of the Japanese people in the video is related to the high levels of HA in their potatoes. I think that the marketers were focused on selling a value added, age-defying HA products.
View: https://www.youtube.com/watch?v=FgJ-bW6txuw
There are also HA preparations for osteoarthritis(OA). These HA preparations are injected directly into the area of the joint. Connie Chung was in a another 'ABC News' YouTube video that identified this medial application:
View: https://www.youtube.com/watch?v=PefdHNnDuv4
Eating a diet rich in plant flavonoids (perhaps the plants shown in the first infomercial but not mentioned as part of the solution)can also cause HA levels in the body to increase. Some of these flavonoids inhibit the activity of the enzyme hyaluronidase (HAase) which degrades HA in the body. If you inhibit the degradation of HA the levels will increase. Combining both by adding exogenous HA in the body and eating plants that contain flavonoids that inhibit the action of HAase in the body appears to be the best way to increase HA. Note - It probably best to take your HA pills separately from when you eat meals containing HAase.
From1990: Structure--activity studies of flavonoids as inhibitors of hyaluronidase
I highlighted the flavonoids from the article that were of interest tome. The highlighted flavonoids in the table all exhibited at least15% inhibition. Would it be correct to assume that their effects in the body would be additive?
These flavonoids are not strangers to this Forum or to my diet. They may have contributed to the healing of my knee that had intermittently nagged me for a long time. As always, your mileage may vary.
The skin care industry and the supplement industry are selling HA products to replenish the levels of HA that naturally decline with age. Mostly, to reduce wrinkles and create a more youthful appearance and also increase health span. Years ago, Connie Chung was in an ABC News interview/infomercial on the miracle of HA that may have launched the HA industry in the US. I think that the infomercial is worth watching. The marketing wizards who brought us this 'ABC News' story suggest that the long health span of the Japanese people in the video is related to the high levels of HA in their potatoes. I think that the marketers were focused on selling a value added, age-defying HA products.
View: https://www.youtube.com/watch?v=FgJ-bW6txuw
There are also HA preparations for osteoarthritis(OA). These HA preparations are injected directly into the area of the joint. Connie Chung was in a another 'ABC News' YouTube video that identified this medial application:
View: https://www.youtube.com/watch?v=PefdHNnDuv4
Eating a diet rich in plant flavonoids (perhaps the plants shown in the first infomercial but not mentioned as part of the solution)can also cause HA levels in the body to increase. Some of these flavonoids inhibit the activity of the enzyme hyaluronidase (HAase) which degrades HA in the body. If you inhibit the degradation of HA the levels will increase. Combining both by adding exogenous HA in the body and eating plants that contain flavonoids that inhibit the action of HAase in the body appears to be the best way to increase HA. Note - It probably best to take your HA pills separately from when you eat meals containing HAase.
From1990: Structure--activity studies of flavonoids as inhibitors of hyaluronidase
I highlighted the flavonoids from the article that were of interest tome. The highlighted flavonoids in the table all exhibited at least15% inhibition. Would it be correct to assume that their effects in the body would be additive?
These flavonoids are not strangers to this Forum or to my diet. They may have contributed to the healing of my knee that had intermittently nagged me for a long time. As always, your mileage may vary.