Boosting levels of Hyaluronic Acid (HA) to more youthful levels with Flavonoids

[David PS]

Hyaluronan/hyaluronic acid (HA) is a biologically important polysaccharide molecule found in the animal kingdom, most notably in the extracellular matrix (ECM)of connective tissues and on the surface of certain pathogenic bacteria. Although HA is found in nearly every tissue of vertebrates, it is abundantly present in the extracellular matrix of soft connective tissues. In mammals, it’s predominantly found in the connective tissue of skin, testes, umbilical cord and synovial fluid.

The skin care industry and the supplement industry are selling HA products to replenish the levels of HA that naturally decline with age. Mostly, to reduce wrinkles and create a more youthful appearance and also increase health span. Years ago, Connie Chung was in an ABC News interview/infomercial on the miracle of HA that may have launched the HA industry in the US. I think that the infomercial is worth watching. The marketing wizards who brought us this 'ABC News' story suggest that the long health span of the Japanese people in the video is related to the high levels of HA in their potatoes. I think that the marketers were focused on selling a value added, age-defying HA products.

View: https://www.youtube.com/watch?v=FgJ-bW6txuw

There are also HA preparations for osteoarthritis(OA). These HA preparations are injected directly into the area of the joint. Connie Chung was in a another 'ABC News' YouTube video that identified this medial application:

View: https://www.youtube.com/watch?v=PefdHNnDuv4


Eating a diet rich in plant flavonoids (perhaps the plants shown in the first infomercial but not mentioned as part of the solution)can also cause HA levels in the body to increase. Some of these flavonoids inhibit the activity of the enzyme hyaluronidase (HAase) which degrades HA in the body. If you inhibit the degradation of HA the levels will increase. Combining both by adding exogenous HA in the body and eating plants that contain flavonoids that inhibit the action of HAase in the body appears to be the best way to increase HA. Note - It probably best to take your HA pills separately from when you eat meals containing HAase.

From1990: Structure--activity studies of flavonoids as inhibitors of hyaluronidase

I highlighted the flavonoids from the article that were of interest tome. The highlighted flavonoids in the table all exhibited at least15% inhibition. Would it be correct to assume that their effects in the body would be additive?

These flavonoids are not strangers to this Forum or to my diet. They may have contributed to the healing of my knee that had intermittently nagged me for a long time. As always, your mileage may vary.

 

[sunny]

I wonder if you can grow or buy those potatoes.

I have been thinking about HA over the years, but have never bought anything with it.

Getting/increasing through the diet seems preferable.

Does anyone have a clean source of HA to DIY a moisturizer?

I have been thinking to DIY a meth blue moisturizer .

And now a HA moisturizer.

THinking urea, HA, MB.

Maybe they should be 3 separate lotions and use alternately.

 

[sunny]

Foods High in Lutein

Lutein is a plant-based nutrient important for your eye health. Learn which 8 foods to eat to get more lutein.

www.webmd.com

 

[sunny]

6 Foods and Drinks That Contain Rutin in Significant Amounts

From buckwheat, apple peel and figs to elderflower infusion and rooibos tea, there are several common drinks and foods that contain the bioflavonoid rutin in significant amounts. Here are our picks of the best dietary sources of rutin.

www.healwithfood.org

 

[sunny]

10 Health Benefits of Hesperidin + Sources & Side Effects - SelfDecode Supplements

Hesperidin, found in orange peels, may protect the blood vessels and help with diabetes and its complications. Read on to learn how to use it safely.

supplements.selfdecode.com

 

[sunny]

100 Quercetin Foods: Best Natural Sources Ranked – Superfoodly

What is quercetin good for and which foods contain the most? Here are the facts and the measured amounts for 100 different sources.

superfoodly.com

 

[aliml]

Hyaluronic Acid Modulation: Preventing Recurrence or Supporting Other Therapies - Otherwise Better Not - Cancer Treatments - from Research to Application

Recently, I was reading this article Why cancer drugs can’t take the pressure, arguing that “A major reason why cancer drugs fail is that they cannot penetrate the high-pressure environment of solid tumors.” and that the reason for that is a “naturally occurring molecule called hyaluronic acid...

cancertreatmentsresearch.com

 

[golder]

My mum has really bad knees. Do we think that topical Apigenin/Naringenin would help alleviate some gif her pain? Thanks in advance!

 

[David PS]

My mum has really bad knees. Do we think that topical Apigenin/Naringenin would help alleviate some gif her pain? Thanks in advance!

I am not in the medical/healthcare industry. I do not think that topical application would do much (if anything). The HA is in the synovial fluid.

 

[golder]

I am not in the medical/healthcare industry. I do not think that topical application would do much (if anything). The HA is in the synovial fluid.

I was thinking of Georgi’s Apigenin in DMSO?

 

[David PS]

I wonder if you can grow or buy those potatoes.

I wonder how much the potatoes contribute to their health span. It looks like an 80% drop in HA by the time they are 60 years old. That is why I wrote about the flavonoids.

Having said that:

13 Foods High in Hyaluronic Acid and Why You Need Them

Choosing the best foods is critical for promoting health and wellbeing. Most of us overlook hyaluronic acid but it can help promote skin and eye health, while reducing joint pain as well.

nutritionyoucanuse.com

 

[David PS]

I was thinking of Georgi’s Apigenin in DMSO?

I did not know that he had a product. Give it try.

 

[David PS]

Hyaluronic Acid Modulation: Preventing Recurrence or Supporting Other Therapies - Otherwise Better Not - Cancer Treatments - from Research to Application

Recently, I was reading this article Why cancer drugs can’t take the pressure, arguing that “A major reason why cancer drugs fail is that they cannot penetrate the high-pressure environment of solid tumors.” and that the reason for that is a “naturally occurring molecule called hyaluronic acid...

cancertreatmentsresearch.com

Thanks this is interesting. I still think that plant based sources of HA and HAase are safe. Pharmaceuticals are sometimes too potent.

 

[Ras]

Showing all foods in which the polyphenol Luteolin is found - Phenol-Explorer

Database on Polyphenols in Foods

phenol-explorer.eu

 

[DennisX]

Hyaluronic Acid Modulation: Preventing Recurrence or Supporting Other Therapies - Otherwise Better Not - Cancer Treatments - from Research to Application

Recently, I was reading this article Why cancer drugs can’t take the pressure, arguing that “A major reason why cancer drugs fail is that they cannot penetrate the high-pressure environment of solid tumors.” and that the reason for that is a “naturally occurring molecule called hyaluronic acid...

cancertreatmentsresearch.com

Many thanks for the references. A number of youtube video DRs aclaim the benifits of HA supplimation. I always post the danger to prostate cancer to those videos but am completely ignored.

 

[Tim Lundeen]

Hyaluronan/hyaluronic acid (HA) is a biologically important polysaccharide molecule...

Thanks, fascinating.

 

[Mauritio]

For arthritis ,HA injections help some people and some not at all. Sometimes it also takes 5-10 sessions until they notice improvements.

 

[David PS]

For arthritis ,HA injections help some people and some not at all. Sometimes it also takes 5-10 sessions until they notice improvements.

An interesting association. A friend of mine teaches board certified anesthesiologist (who are MDs with 4 extra years of formal training how to and where to precisely inject anesthesia into tissues surrounding nerves to block nerve pain during and after surgery. My friend has many stories about how the doctors who are being trained do not know their anatomy and miss the target (area surrounding the nerve) by such a wide margin that the normal diffusion of the anesthesia is not enough to get the job done.

By analogy, do you think that doctors who are not specially trained in HA injections might have missed their target? If so would they admit to the insurance company and the patient that they missed but should get paid anyway? Could they have missed their mark repeatedly?

 

[David PS]

Showing all foods in which the polyphenol Luteolin is found - Phenol-Explorer

Database on Polyphenols in Foods

phenol-explorer.eu

Nice database but the "all foods" is just all the foods in the database not all all the foods in the world.

37 Luteolin Rich Foods Ranked by Luteolin Density | Hydration Monitoring - Intake Health Blog

Learn more about the dietary flavanoid luteolin, and see the top food sources of luteolin with our ranking of 37 luteolin rich foods!

www.intake.health

 

[Mauritio]

An interesting association. A friend of mine teaches board certified anesthesiologist (who are MDs with 4 extra years of formal training how to and where to precisely inject anesthesia into tissues surrounding nerves to block nerve pain during and after surgery. My friend has many stories about how the doctors who are being trained do not know their anatomy and miss the target (area surrounding the nerve) by such a wide margin that the normal diffusion of the anesthesia is not enough to get the job done.

By analogy, do you think that doctors who are not specially trained in HA injections might have missed their target? If so would they admit to the insurance company and the patient that they missed but should get paid anyway? Could they have missed their mark repeatedly?

Good point, it might have to do with that. I even remember one patient telling me there was spontaneous success by the 11th or 12th session or befoer that nothing.

Im almost certain that they would not admit under any circumstance that they made a mistake. Its even rare to have a doctor admit that another doctor made a mistake .

Just yesterday I was talking to a patient who had permanent brain damage from hypernatremia. She said she got a NaCh infusion in the hospital and the dosage she was supposed to get over a period of days, she got in less than a day. Nobody even told her she had brain damage until she came to a new hospital, where the new doc couldn't believe what had happened and said he would have her back in the case of a lawsuit. But thats pretty much the only time I've ever heard a doctor beein so supportive.
Now she can barely work anymore , needs constant therpay and is on high dose opiates. No compensation from the hospital in any shape or form.