- Joined
- Aug 24, 2017
- Messages
- 5,858
Aspirin on testosterone, dopamine and sexual function » TESTONATION
Aspirin is typically thought of as a simple pain relieve medication, but recent studies have uncovered surprising connections between taking aspirin and testosterone levels in men. In this blog post, we'll explore how aspirin can impact testosterone levels and what this means for men who are...
men-elite.com
There has been quite a lot of talk about aspirin and testosterone on this forum, so I compiled all the research on it that I could find.
The potential beneficial mechanisms of aspirin on testosterone in humans are by:
- Inhibiting COX-2 and prostaglandin production
- Increasing lipoxygenase (LOX) (inhibiting LOX inhibited LH and cAMP stimulated steroid production in rat Leydig cells) (R)
- Producing pro-resolvins
- Increasing GnRH release suppressed by opioids. Opioids inhibit GnRH by producing prostaglandin and aspirin inhibits this. Natural opioids are frequently elevated by stress. Gluten and dairy also contain strong natural opioids that might lower testosterone.
I also touched on the effects of aspirin on estrogen, cortisol, serotonin, dopamine and sexual function.
I like it a lot, but only use it on demand now. When I was hypometabolic, I used it daily in doses of 1g usually. It helped the most by increasing my temps, reducing anxiety, improving my mood (I was quite depressed and anhedonic back then), helping me to focus and helping me get back to sleep after I got stress responses during the night.