atp

  1. Hans

    Tired of feeling anxious and submissive? Here’s how to fix it

    It all comes down to energy production. How effectively your cells can produce energy. https://men-elite.com/2021/08/16/tired-of-feeling-anxious-and-submissive-heres-how-to-fix-it/ I'd also like to hear from you. What has worked great for you to optimize both your energy and reduce anxiety?
  2. haidut

    Muscle weakness / wasting linked to poor mitochondrial function

    A study that once again illustrates the central principle of bioenergetics - structure and function cannot be separated. They are interdependent at every level. In this specific case, the "structural" pathology is muscle weakness and wasting (sarcopenia, cachexia, etc). Most doctors, when...
    • haidut
    • Thread
    • atp atrophy cachexia metabolism mitochondria muscle weakness oxphos sarcopenia
    • Replies: 4
    • Forum: Scientific Studies
  3. Hans

    PUFAs, cardiolipin, ATP production and obesity

    As we all know, PUFAs are a metabolic toxin. One of the mechanisms how a high fat diet promotes obesity and metabolic syndrome is by remodeling cardiolipin. Cardiolipin is a unique mitochondrial phospholipid that contains 4 fatty acids. Its main goal is to stabilize the complexes of the electron...
    • Hans
    • Thread
    • atp cardiolipin electron transport chain energy pufas saturated fat
    • Replies: 6
    • Forum: Scientific Studies
  4. Hans

    Fructose series part 1: fructose depletes ATP?

    Every heard that fructose might deplete ATP? That's one silly argument that I debunk here. https://men-elite.com/2021/02/18/fructose-series-part-1-fructose-depletes-atp/
  5. haidut

    Niacinamide may treat ALS by improving energetic state

    Another study sent to me by the Austrian collaborator. Once again, the energetic origin of "incurable" diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic...
    • haidut
    • Thread
    • als atp glycolysis lactate niacinamide nicotinamide oxphos vitamin b3 warburg
    • Replies: 0
    • Forum: Scientific Studies
  6. haidut

    Niacinamide may treat depression by improving energetic state

    A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without...
    • haidut
    • Thread
    • atp depression fao fatty acid oxidation niainamide nicotinamide sirt1 vitamin b3
    • Replies: 11
    • Forum: Scientific Studies
  7. S

    Starting Anti Glycolytic Kettlebell Training

    Using Pavel's The Quick and the Dead. Not too sure what to put in log here, so here goes: Age 53 Sex M Weight 248 Height 5'11" Waking temp: 98.2 - 98.8 Health and stats steadily improving over last 8 months of Peating. This type of trainingg is supposed to increase ATP and mitochondrial...
    • Sullytex
    • Thread
    • atp exercise kettlebells mitochondria
    • Replies: 1
    • Forum: Exercise
  8. haidut

    Restoring Metabolism Prevents / Reverses "permanent" Nerve Damage

    Yet another study demonstrating the crucial role cellular metabolism plays in pathological processes. While most of my posts deal with beneficial effects of improving OXPHOS on various chronic diseases, the study below demonstrates that the same may be true in acute pathologies such as traumatic...
    • haidut
    • Thread
    • atp brain cns creatine energy injury mitochondria nerve tbi
    • Replies: 34
    • Forum: Scientific Studies
  9. haidut

    Glucose Is Anabolic For Thymus, Opposes Catabolic Effects Of Cortisol

    As most of my readers know, cortisol is a highly catabolic steroid and one of the main agents (estrogen being another) responsible for thymus atrophy with age. These catabolic effects of cortisol can be blocked by progesterone, DHEA, pregnenolone, and even DHT (but not by testosterone). The...
    • haidut
    • Thread
    • anabolic atp glucose immune system immunity inosine nucleotides pyruvate regeneration thymus
    • Replies: 7
    • Forum: Scientific Studies
  10. haidut

    Niacinamide May Restore Female Fertility In Old Age

    The mainstream medical dogma is that after the onset of menopause, female reproductive potential is essentially zero. I posted a thread recently that challenged that dogma and demonstrated that infertility is essentially an energetic dysfunction process and can be reversed with exposure to red...
    • haidut
    • Thread
    • aging atp energy female fertility menopause metabolism nad niacinamide nicotinamide mononucleotide nmn
    • Replies: 30
    • Forum: Scientific Studies
  11. haidut

    Mitochondria (energy) As The Main Driver Of Health, Intelligence, And Aging

    We are finally starting to see Peat enter the mainstream and article like the one below are calling for a complete review of what we know about health and aging and how intelligence is tied to them. As the authors says, or actually borrows from Peat, there is solid evidence that mitochondrial...
    • haidut
    • Thread
    • aging atp chronic stress disease energy health intelligence metabolism mitochondria oxidative phosphorylation stress
    • Replies: 17
    • Forum: Scientific Studies
  12. haidut

    Fertility Depends On Metabollism (ATP), Not Age

    As many of you know, there are 2 fundamental dogmas in reproductive medicine. One is that every woman is born with a fixed number of eggs and those cannot be replenished. The second one is that there is a biological fertility clock in every woman that inexorably ticks, and if the female does not...
    • haidut
    • Thread
    • age aging atp eggs energy female fertility gonads lllt male metabolism ovaries pregnancy red light reproduction reproductive health testicles
    • Replies: 17
    • Forum: Scientific Studies
  13. haidut

    Chronic Stress / Defeat Causes Mental Illness By Damaging Mitochondria

    Yet another study demonstrating that mental illness has little to do with genetics, and is likely entirely due to energetic deficiency caused by environmental stress. This energetic deficiency is caused by mitochondrial damage caused by said stress. Keeping lipolysis and/or PUFA intake low can...
    • haidut
    • Thread
    • anxiety atp bipolar disorder cause defeat depression energetics mental illness metabolism mitochondria stress
    • Replies: 12
    • Forum: Scientific Studies
  14. M

    Serotonin Injection Induces A Dramatic Fall In Brain ATP Levels

    This is a study from 1994 by Koren-Schwartzer et al. that is often cited often by Ray Peat. It shows that intraperitoneal serotonin injection (40 mg/kg) causes a dramatic fall in brain ATP levels (24% of normal level). What I don't understand is how the injected serotonin in the peritoneum can...
  15. haidut

    Liver Disease Is Caused By Low ATP Driven By Fat (PUFA) Oxidation

    I posted a study several months ago on the ability of inosine to prevent/reverse liver disease, and how liver damage caused by various toxins was due to lower ATP levels in the liver. Inosine, being both a metabolite and precursor of ATP, is able to restore ATP levels and as such to...
    • haidut
    • Thread
    • atp cardiolipin cirrhosis fao fas fatty acid oxidation fatty acid synthesis liver liver disease mitochondrial dysfunction nafld nash peroxidation pufa
    • Replies: 26
    • Forum: Scientific Studies
  16. haidut

    Morphostasis Theory Of Immunity Confirmed - Body Treats Heart Attack Like Viral Infection

    Peat has touched upon his views of the immune system in several articles, mostly related to autoimmune disease. In his view, the role of the immune system is not so much to "attack" foreign pathogens that threaten the organism, but is more akin to sanitation workers who clean up trash and other...
    • haidut
    • Thread
    • atp energetics energy fibrosis heart attack immune system immunity inflammation morphostasis oxidative metabolism oxphos viral infection virus
    • Replies: 8
    • Forum: Scientific Studies
  17. haidut

    Simple Body Stretching Reduces Tumor Size By More Than 50%

    As many of you know, stretching is known to increase ATP levels in muscle. The effects is the reverse of the one caused by contracting, which breaks down ATP. User @Such_Saturation posted a study about that and Peat has mentioned it many times as well. Stretch Creates ATP In the Cardenosine...
    • haidut
    • Thread
    • atp cancer growth immune dysfunction immune system inflammation shrink stretching
    • Replies: 41
    • Forum: Scientific Studies
  18. haidut

    Cardenosine - Liquid Product For R&D

    Our new product is finally here and it is "all about the ATP". I mentioned quite a few times on the forum and over email that we plan on releasing an ATP product and people have been asking me about it for the last few months. It seems a very simple task at first but we thought that we can do a...
    • haidut
    • Thread
    • aging atp cancer cardenosine cortisol dopamine infection inflammation inosine ketoproline metabolism oxoproline p5p pyridoxal-5-phosphate pyroglutamate pyroglutamic acid serotonin succinate succinic acid vitamin b6
    • Replies: 409
    • Forum: IdeaLabs
  19. haidut

    Inosine Powerfully Stimulates Mitochondriogenesis, Oxidative Metabolism & Cell Differentiation

    Yet another absolutely great study on inosine. It shows that not only can inosine replenish ATP (as shown in the previous studies I posted) but it can inhibit excessive glycolysis, lower lactate, and dramatically improve oxidative metabolism - effects which are key driver of cell differentiation...
    • haidut
    • Thread
    • atp cancer differentiation glycolysis inosine lactate ldh mitochondria mitochondrial respiration mitochondriogenesis oxidative metabolism respiration
    • Replies: 27
    • Forum: Scientific Studies
  20. haidut

    Inosine Increases ATP And Reverses NAFLD (and Likely Other Liver Disease)

    As I mentioned in another recent thread on inosine and serotonin/cortisol, many pathologies are simply signs/symptoms of inefficient ATP synthesis and restoring proper synthesis or replenishing ATP levels through precursors often reverses the pathology. These two studies below show that fatty...
    • haidut
    • Thread
    • atp fatty liver inosine liver disease nafld protein synthesis purine purine salvage pathway purine synthesis
    • Replies: 39
    • Forum: Scientific Studies
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