From my experience almost immediately.@charlie How quickly does niacin start moving heavy metals out? I’ve never heard of it being a chelator before.
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From my experience almost immediately.@charlie How quickly does niacin start moving heavy metals out? I’ve never heard of it being a chelator before.
Yes I have heard of people flushing and having symptoms of flushing the next day.Anyway - yesterday I took a pinch of it in my water (way less than I did that first time ) and barely felt anything. 24 hours later I’m expericning the same head pressure and burning sensations in my mouth. I feel super awful but I’m not sure I can chalk it up to niacin since it occurred so much later I’m at the ER just incase. @charlie I know you have talked about avoiding niacin if you are extremely toxic and I know I am probably mercury toxic or something else. But have you ever heard of the flush symptoms occuring that long after taking Niacin and lasting five hours and counting? This couldn’t be the niacin I took at 11 am yesterday even though symptoms feel very similar?
It’s been over 48 hours and I’m still getting flushing and burning sensations everytime I move my head and arms. It’s very odd. Ct scan was clean. Im starting to wonder if the niacin wasn’t eliminated or is binding to something to prevent it from being excreted and keeps causing a flush.Yes I have heard of people flushing and having symptoms of flushing the next day.
Sounds like you moved a bunch of metal and are dealing with the aftermath. How much did you take? Dr. Garrett Smith advises people to start out at 25mg. I usually advise my family members to start around 50 to 60mg.It’s been over 48 hours and I’m still getting flushing and burning sensations everytime I move my head and arms. It’s very odd. Ct scan was clean. Im starting to wonder if the niacin wasn’t eliminated or is binding to something to prevent it from being excreted and keeps causing a flush.
Very scary situation I’m in.
More than that I’m sure. Probably closer to 4-500mg which the package says is a normal doseSounds like you moved a bunch of metal and are dealing with the aftermath. How much did you take? Dr. Garrett Smith advises people to start out at 25mg. I usually advise my family members to start around 50 to 60mg.
That is a pretty hefty dose to start with.More than that I’m sure. Probably closer to 4-500mg which the package says is a normal dose
I currently take 2-4 2nd gen antihistamines a day to help MCASList every supplement you are currently taking (and approximate dosage) and your main foods you are eating, please.
I currently take 2-4 2nd gen antihistamines a day to help MCAS
I take a beta blocker twice a day for POTAS
Right now I’m trying flush Niacin and NAC, and then I try this and that but never for long. I’ve tried high dose thismine and b12 shots , magnesium , I try to get enough potassium. I’ll take riboflavin too.
My diet isn’t good and Im so unwell I take what I get from whoseveres making it. The vast majority is muscle meat. But I snack on things like chocolate and potatoes chips. I avoid dairy , don’t eat much fruit and vegetables at all and no eggs or organ meat.
I don’t know what to look for when it comes to liver or bile issues. I’m often having diahhrea or severe constipation. I can often go days without moving my bowels. I’ll every now and again have blood in my stool but colonoscopy always normal.
It can be a sign of a stagnant liver/gallbladder.
Signs of good bile flow:
brown, sticky, sinking, well-formed stool, good tolerance to dietary fats, 1-3 bowel movements a day, blood lipids like total cholesterol in the healthy range, low liver enzyme readings.
Signs of stagnant bile flow („cholestasis“)
pale or yellow stool color, loose stool, undigested food in stool, fat malabsorption, upper right quadrant abdominal tension, constipation, sometimes mixed with diarrhea, SIBO, nonspecific itching, yellow tint of the skin, dark urine and irritability.
Thanks I’ll look into himI recommend you to look into Dr. Kuklinski‘s work. He has written a lot on nitrosative stress and how it inhibits mitochondrial respiration. He recommends B12 for that — always combined with biotin and folate for that. Also thinks highly of CoQ10, alpha lipoic acid, B1, B2, B3, B5 for optimizing pyruvate dehydrogenase, TCA and electron transport chain.
He has a lot of successful case reports from his clients with CFS, diabetes, even some cancer cases, cardiovascular issues, asthma, migraines, IBS etc etc
He recommends extensive lab testing and very rarely muscle biopsy.
He has only written in german but you may be able to translate it:
Do anticholinergics like Benadryl improve your symptoms?Thanks I’ll look into him
There’s one thing I need to fully understand though and that’s if the possibility even exists that the acetylcholinesterase can be dysfunctional as long as it has been for me simply by being “poisoned” with heavy metals and whatever else I can’t detox. So when new acetylcholinesterase is synthesized it’s also almost immediately rendered useless OR it’s not being synthesized in the first place. Whatever’s happening would be inhibiting this enzyme well over 15 months now. As long as that seems like it’s reasonably possible with bad heavy metal toxicity then I’d certainly continue chasing the acetylcholine excess causing chronic wheezing theory but I’m still not entirely convinced that could happen as it’s playing out currently. Like I said earlier , this all started on Acetylcholinesterase inhibitor Huperzine and just didn’t revert back to normal. It’s the best theory I have going.
Not in any meaningful way with the breathing. Sometimes I feel like it’s easier to expand. The way I understand it though is that Benadryl will only block receptors that aren’t already occupied by acetylcholine, so if the AchE isn’t functioning then it won’t affect it any meaningful way. I could be wrong about that.Do anticholinergics like Benadryl improve your symptoms?
I’m trying forskolin but it hasn’t been hugely beneficial yetYour hypercholinergic symptoms are similar to mine except I believe Myo inositol was the culprit in my case. Although I did trial galantamime for 2 days later on which caused myoclonus to a ridiculous extent.
I have hypersalivation, muscle twitching/spasms and I also have some weird form of GERD that is likely related to acetylcholine. None of this lets up at all and I am literally swallowing saliva non stop.
Like you I have POTS and dysautonomia but this was caused by taking nortriptyline.
I've also been looking for ways to increase acetylcholinesterase but there doesn't seem to be many options unfortunately.
Easy to increase but difficult to reduce for some reason