S.Holmes
Member
I skimmed this study looking for in vivo experiments. It looks like they were using vit A in supplement form, not from food. That would be like saying red meat is bad because of toxic iron. We all know you can get too much of a "good" thing.I think it needs to be combined. We need to be able to have good ALDH and retinol binding protein (zinc dependent becomes it seems this is more like an antibody wrapper it completely encapsulates the retinol) and good bile flow to not be harmed by what comes out. Vit A is rapidly cleared from the blood when they have given a supp to people. Where is it going? It's shuttled away into our fatty tissues.
Check out this study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452429/
Overall, such findings indicate a potential ability of vitamin A and its derivatives to negatively interact with biological membranes, an event that may lead to organelle stress, as, for instance, mitochondrial dysfunction, and to cell apoptosis or necrosis.
‘Vitamin A and its derivatives, the retinoids, disrupt mitochondrial function by a mechanism that is not completely understood. However, it accounts with impaired electron flux between the complexes of the METC, increased ROS production, and induction of oxidative and nitrosative stress to mitochondrial membranes. Additionally, vitamin A and retinoids alter the mitochondrial structure by causing swelling of the organelle. More investigations are needed to elucidate how vitamin A and retinoids affect mitochondria and whether there is a causative link between such event and the clinical manifestations observed both experimentally and in humans.’
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The in vivo doses used in rodents were 1000 to 9000 IU. Any adult taking the equivalent dose would likely end up in the hospital.
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