InChristAlone
Member
Fever rapidly detoxes poison A. Voila cured.
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I am looking for a Succinate product that does not contain silica, which product do you use?Glad to see I am in your thoughts ima-maniac. I am back on Vit E Succinate, Inosine, Selenium, and Idea labs Energin, Magnaoil, K2, and D3
Why is it sad? If you read the abstract both the ORR (tumour shrinkage) and duration of response were met. At SITC the company present data on the intratumoral injected 20 mg dose. It provides increased activity with a similar safety profile as that seen in the 10 mg dose. There was a positive trend of more rapid and deeper abscopal responses. Based on preclinical data a triplet treatment of G100, anti-CTLA4 and anti-OX40 injected into a single lesion is able to cure mice with established disease Intratumoral Injection of TLR4 Agonist (G100) Leads to Tumor Regression of A20 Lymphoma and Induces Abscopal Responses This has been shown by other groups as well JCI - Depleting tumor-specific Tregs at a single site eradicates disseminated tumors Eradication of spontaneous malignancy by local immunotherapy
Chronic TLR4 agonism (usually from endotoxin) is perhaps the main metabolic pathway through which most cancers start. Opioids are potent TLR4 agonists, and they have been used on cancer patients for decades. I have to hear of anybody getting better from using them. Short-term improvements are not impossible and similar approaches have been used in the past by injecting TNF-a. Yet, nobody was ever cured, patients quickly regressed and that approach was abandoned. Google for "TNF therapy in cancer". Here is something as a start.
Tumor necrosis factor and cancer, buddies or foes?
"...Although TNF has cytotoxic, cytostatic, and immunomodulatory effects on malignant tumors, using TNF as a chemotherapeutic drug has been hampered by its deleterious side effects, including systemic shock and widespread inflammatory responses. In addition, many cancer cells are resistant to TNF-induced cytotoxicity."
For the G100 trial the FDA said they wanted to an ORR (tumour shrinkage) of at least 40% and duration of response of at least 10 months. The ASH abstract shows the ORR was 54% and duration of response over 11 months. The patient population had failed three-lines of prior therapy. Using the higher dose both shrinkage and duration should improve.
As for TNF there are ways to sensitize patients to it (IAPi). Based on the mechanism of action of STING agonists (these are injected directly into a tumour) it makes sense to test these along with oral small molecule inhibitors of IAP IAP inhibitors enhance co-stimulation to promote tumor immunity
That study looked at temperatures exceeding 105. I don't think I have even achieved a fever that high in my life. And 107 can be deadly. Has anyone fried their body from using a heat lamp?When the heat is generated outside of the body, it can spare nutrition to mount a proper immune response during hyperthermia and control stress.
Selected Contribution: Hyperthermia-induced intestinal permeability and the role of oxidative and nitrosative stress
Light is great, but it might be depleting for this purpose. It's related to a discussion with the one and only 'yitsmonkey'.
It requires abstraction on your part. Sometimes I leave information without context thinking it could be interesting for people to interpret however they like, but it doesn't work as expect because I eventually have to explain myself later.That study looked at temperatures exceeding 105. I don't think I have even achieved a fever that high in my life. And 107 can be deadly. Has anyone fried their body from using a heat lamp?
But there is a lot to consider. That's what I am saying. Why would the body mount a 103 fever in the face of a bad infection while also allowing the gut to be permeable? Maybe that is what causes sepsis? But then that doesn't happen for most people. I just had a fever of 101 and I'm feeling like I'll come out the other side better than before. Heat stress can go along with dehydration and excessive activity. And we already know that long distance runners are destroying their gut. But compare that to a day at the beach or sitting under a heat lamp for a while... I'm pretty sure which ones I would choose for my health...It requires abstraction on your part. Sometimes I leave information without context thinking it could be interesting for people to interpret however they like, but it doesn't work as expect because I eventually have to explain myself later.
But that's the extreme, however heat stress is known for amplifying current stressors. Leaky gut is common and during sustained hyperthermia it can be made worse. Temperatures that cause discomfort are stressful, but this is the goal of this sort of approach.
Heat stress, gastrointestinal permeability and interleukin-6 signaling — Implications for exercise performance and fatigue
"During either passive or exertional heat stress, GI permeability can be exacerbated due to rising core temperatures and preferential blood flow away from the splanchnic area, which can directly open the tight junctions and cause tissue hypoxia, oxidative stress, and damage the enterocyte membrane.29 Consequently, the damaged epithelial wall and tight junctions allow translocation of luminal LPS into the blood stream.30"
The problem is that this is an artificial fever, no longer autonomic control, and people might stay on it longer than they should for lacking awareness or believing that it's a sign that toxins are being expelled.But there is a lot to consider. That's what I am saying. Why would the body mount a 103 fever in the face of a bad infection while also allowing the gut to be permeable? Maybe that is what causes sepsis? But then that doesn't happen for most people. I just had a fever of 101 and I'm feeling like I'll come out the other side better than before. Heat stress can go along with dehydration and excessive activity. And we already know that long distance runners are destroying their gut. But compare that to a day at the beach or sitting under a heat lamp for a while... I'm pretty sure which ones I would choose for my health...
When the heat is generated outside of the body, it can spare nutrition to mount a proper immune response during hyperthermia and control stress.
Selected Contribution: Hyperthermia-induced intestinal permeability and the role of oxidative and nitrosative stress
Light is great, but it might be depleting for this purpose. It's related to a discussion with the one and only 'yitsmonkey'.
That's how I imagine someone saying your username in spanish.ahem, I think you misspeeled Ditz
That's how I imagine someone saying your username in spanish.
Explains the low incidence of cancer in Asia. Asians have thymal persistence and low estrogen as well. I'm not sure to what extent the former is caused by the latter.I think the proper immune approach to cancer comes down to intact thymus, which depends on low estrogen/cortisol.