Another great interview to listen to again and again. Download pdf transcript available.
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“Rate-of-living theory underpins this whole concept of oxidative stress. Currently, pretty much every doctor will tell you that the higher your metabolic rate — which means the quicker the electrons move from food towards oxygen, which is the final acceptor of electrons — the faster you'll age because there'll be higher oxidative stress. You'll be producing a higher amount of reactive oxygen species (ROS).
But if you look at the actual data, and this is even in the medical books, it turns out it's the exact opposite. ROS are generated from oxygen, but it's actually when you're NOT shuttling the electrons fast enough towards oxygen.
And, when these electrons [from food] build up in various chunks of this process, whether it's in the Krebs cycle or the electron transport chain, you have to do something with them.
If you look at what a reactive oxygen species is, you'll see that it's actually oxygen that has been reduced, in other words, oxygen that has gained an electron. Now, an electron, by its nature, is a reductive species. Basically, a food is a donor of electrons, a reductant.
Oxygen is an acceptor of electrons, an oxidant. So, if you have a buildup of electrons, this means that you are in a state of excessive reduction, or at least higher than optimal.
So, your body has to do something with them. You're giving the body electrons, either from food or through lipolysis, or the cortisol-generating amino acids from your muscles. Ultimately, all of these things get converted to energy, and the way energy works is, it's a flow of electrons.
So, electrons, ideally, should be paired at the very end with oxygen through Complex 4 of the electron transport chain. If that does not happen, then these electrons can attack oxygen molecules [moving through the metabolic chain] and reduce them by an electron or two, [which] generates these very reactive species.”
“The determining factor for most of the creation of the ROS is the NADH to NAD+ ratio. NADH being the reduced form and NAD+ the oxidized form. This ratio also controls the speed of metabolism of carbohydrates because the rate limiting step is pyruvate dehydrogenase.
When you're in the oxidized state, in other words, NAD+ predominates, then pyruvate-dehydrogenase works well and electrons flow through the Krebs cycle and the electron transport chain ...
When NADH predominates, you have too many electrons ... that are not meeting oxygen properly. This buildup of electrons creates these bottlenecks, either in Complex 1 or Complex 3, mostly ... Then something has to happen with these electrons. Two things can happen. One is increased synthesis of the ROS. Second, your body uses these extra electrons to synthesize fats.
So, you can view obesity, or at least extreme obesity, as a desperate mechanism to get rid of electrons that are coming from food but are not getting processed properly. In other words, you're not combusting the food properly. So, what happens with it? Well, you store it. That's the only thing that the body can do.
And, by the way, whenever you have obesity or severe overweight, you always have high amounts of ROS, because those are the only two things that the body can do with the extra electrons. It cannot simply evaporate them, though there's some research on grounding that [shows] you can help get rid of the excess electrons [that way].”
“So, basically, by taking vitamin E, whatever estrogenic effects are out there, even from nonperoxidized PUFA, or if you're producing too much estrogen for whatever reason, if you have endocrine disruptors which are capable of binding and activating the estrogen receptor just like estrogen does, tocopherol will block some of that,” Dinkov says.
“It's really a versatile molecule that has genomic steroid-like effects, but it mimics progesterone, which is also the main anti-estrogen in the body for females, testosterone and the dihydrotestosterone being the main anti-estrogens in the body of males.
Tocopherol will have most of these effects. And it probably has much fewer side effects than taking steroids. The daily needs have been shown to correlate perfectly with your intake and storage of PUFAs, so the daily need, the real RDA, of vitamin E is about 2 mg of vitamin E for every gram of PUFA consumed, which means, if you're consuming 50 grams of PUFA, you need 100 mg vitamin E to combat its peroxidative and estrogenic potential.
Most people are used to measuring the vitamin E in units. If you take the vitamin E dosage in milligrams and multiply by 1.5, you get the dosage in international units.”
I wholeheartedly agree. I think the mercola interviews have given Georgi a much wider audience, and the synergy between them is great. Mercola has been in the game for a long time, but it is apparent in the interviews that he is being exposed to new info and another point of view from the Peat/ Georgi perspective. Mercola seems to have ditched the keto, high fat in favor of carbs. He mentioned he is about to release a 50 mg niacinamide tablet. I do hope he sees the value of crediting Ray Peat and Georgi Dinkov in his future views on what perpetuates a healthful life.@sunny - Thanks for information.
I read the pdf and noticed that it ended with:
More Information
You can check out Georgi’s blog at www.haidut.me or follow him on Twitter. He also has
hundreds of videos on YouTube on a plethora of topics. A major sampling of Ray Peat’s
work is also available for free on these two sites: wiki.chadnet.org/Ray-Peat and
RayPeat.com.
I do not remember chatnet.org being mentioned in any interview. That would indicate to me that Mercola (or members of his team) visit the Forum.
When I listened to Mercola interview Georgi, I thought that he was preparing to write another new book. I hope that Dr. Peat is given credit for originating many of these concepts. In addition, I hope that Georgi is identified as his personal tutor.
Dr. Mercola is always extremely grateful and gracious about crediting Georgi & Ray Peat. I watch many other Mercola interviews and he mentions both all the time and credits them all the time. For you to think any other way is you being petty, certainly not Dr. Mercola. He is a confident enough man to acknowledge the shoulders he is standing on.@sunny - Thanks for information.
I read the pdf and noticed that it ended with:
More Information
You can check out Georgi’s blog at www.haidut.me or follow him on Twitter. He also has
hundreds of videos on YouTube on a plethora of topics. A major sampling of Ray Peat’s
work is also available for free on these two sites: wiki.chadnet.org/Ray-Peat and
RayPeat.com.
I do not remember chatnet.org being mentioned in any interview. That would indicate to me that Mercola (or members of his team) visit the Forum.
When I listened to Mercola interview Georgi, I thought that he was preparing to write another new book. I hope that Dr. Peat is given credit for originating many of these concepts. In addition, I hope that Georgi is identified as his personal tutor.
He's one of the few Doctors/Health Front Runners ythat will openly admit he's wrong. As he experiments on himself, N=1, as he gathers more data, facts, etc. he revises his opinion and advise. Which is intelligent, wise and the correct thing to do. Everyone else digs their heels in or climbs the Ivory Tower and refuses to change.While I trust almost anything Georgi says, I don't' trust Mercola. He's a zebra that's changed it's stripe. 5-8 years ago he was vehemently recommending fish oil and sold a fish oil product. I don't believe anything Mercola says.
Agreed. But for me, fool me once shame on you, fool me twice shame on me. I'd rather skip that researcher. than trust again.He's one of the few Doctors/Health Front Runners ythat will openly admit he's wrong. As he experiments on himself, N=1, as he gathers more data, facts, etc. he revises his opinion and advise. Which is intelligent, wise and the correct thing to do. Everyone else digs their heels in or climbs the Ivory Tower and refuses to change.
If you watched this interview he openly admitted he was wrong in it about certain things. Most people would be wise to follow a similar path.......be humble & intelligent enough to admit when you're wrong! As more pieces of the puzzle are acquired we all need to adapt and be pliable. As they saying goes.......bend like the willow or snap off and break like the oak!
Good Luck in your world of perfect people that never make mistakes! Kinda like 'finding Hen's teeth'Agreed. But for me, fool me once shame on you, fool me twice shame on me. I'd rather skip that researcher. than trust again.
Mercola addressed the Sunflower Oil in the interview.Mercola.com store does have the 50mg Niacinamide 270 tablets. Niacin (as Niacinamide) (vitamin B3) Other ingredients: Mircocrystalline cellulose, silicon dioxide, organic tablet coating (organic tapioca maltodextrin, organic sunflower lecithin, organic palm oil, organic guar gum) rice bran extract, rice hull, gum acacia, sunflower oil. Is sunflower oil a PUFA?
Did I miss the video on this interview? Where is it? Also haidut said in his blog .... So I wonder if he himself takes Urolithin A or if anyone here takes it. Too bad it is so expensive!!A monkey could host Georgi and it would be great watching. The guy is just a standalone brilliant communicator