ampersand
Member
- Joined
- Jul 4, 2015
- Messages
- 82
I'm hoping someone could answer a quick question for me. A relative of mine has non-small cell lung cancer that has metastasized to the lining of his brain, and his most recent prognosis is 3-6 months. I'm reading about fenbendazole and mebendazole, both of which can penetrate the blood-brain barrier and have some interesting anti-cancer properties, but they have low solubility in water so it can be difficult to get high concentrations of the drug into the body from oral ingestion. So I was wondering if people have tried using DMSO as a carrier.
I came across this product ( https://cdn.caymanchem.com/cdn/insert/18872.pdf ) being sold for research purposes, but I don't understand one of the lines: "Mebendazole is soluble in the organic solvent DMSO, which should be purged with an inert gas, up to a concentration of approximately 10 mM." I don't have any chemistry or biology background, can anyone explain to me what they mean by "purged with an inert gas"?
Does it seem plausible that this is a drug that would be effective applied topically? I'm still trying to do more reading, but figured I'd ask just in case someone here already has an opinion on this.
I came across this product ( https://cdn.caymanchem.com/cdn/insert/18872.pdf ) being sold for research purposes, but I don't understand one of the lines: "Mebendazole is soluble in the organic solvent DMSO, which should be purged with an inert gas, up to a concentration of approximately 10 mM." I don't have any chemistry or biology background, can anyone explain to me what they mean by "purged with an inert gas"?
Does it seem plausible that this is a drug that would be effective applied topically? I'm still trying to do more reading, but figured I'd ask just in case someone here already has an opinion on this.