LeeLemonoil
Member
- Joined
- Sep 24, 2016
- Messages
- 4,265
I'm fairly convinced that a great deal of the posiive mental effects of DHT actually stem from this metabolite of it:
https://en.wikipedia.org/wiki/3β-Androstanediol
it binds on ERß primarily but the classification as an estrogen is misleading, it's more likely the major androgenic metabolite to keep genuine, detrimental estrogenic action in check in the male physiology, as well as in females to a certain degree.
which is on another pathway also a metabolite of DHEA.
The enzymes required for these pathways are 17β-Hydroxysteroid dehydrogenases and 3β-Hydroxysteroid dehydrogenase respectively.
According to this piece : http://meridianvalleylab.com/testosteron-metabolite-3b-adiol
substances that upregulate these enzymes or are needed as rate limiting co-factors are Zinc, acids found in Coconut oil and olive oil, Retinoids and retinoic acids, Lithium, Niacinamide ... Sounds very peatish.
On the other hand I don't know the quality and validity of all the claims made in that piece - he is wrong for example that 3ß-diol cannot be convertrd back to DHT, it can and it does.
Nevertehless, a very intriguing steroid-hormone and as the wiki-entry states. there was also a synthetic derivate already in production. If only one could get the hands on it ...
https://en.wikipedia.org/wiki/3β-Androstanediol
it binds on ERß primarily but the classification as an estrogen is misleading, it's more likely the major androgenic metabolite to keep genuine, detrimental estrogenic action in check in the male physiology, as well as in females to a certain degree.
which is on another pathway also a metabolite of DHEA.
The enzymes required for these pathways are 17β-Hydroxysteroid dehydrogenases and 3β-Hydroxysteroid dehydrogenase respectively.
According to this piece : http://meridianvalleylab.com/testosteron-metabolite-3b-adiol
substances that upregulate these enzymes or are needed as rate limiting co-factors are Zinc, acids found in Coconut oil and olive oil, Retinoids and retinoic acids, Lithium, Niacinamide ... Sounds very peatish.
On the other hand I don't know the quality and validity of all the claims made in that piece - he is wrong for example that 3ß-diol cannot be convertrd back to DHT, it can and it does.
Nevertehless, a very intriguing steroid-hormone and as the wiki-entry states. there was also a synthetic derivate already in production. If only one could get the hands on it ...