haidut
Member
It is well known that clonidine lowers adrenalin, and Ray has written about it. It looks like clonidine is also able to restrain the other side of the sympathetic stress response - the ACTH, cortisol, hyperglycemia process. All studies below are in humans. So, it looks like clonidine may be a good option for stopping the stress response in people who have trouble regulating it with just sugar, salt and protein. There are quite a few studies showing benefit from short-term low-dose clonidine administration on stress paramaters induced by events like surgery, septic shock, trauma, etc. Average duration is about 3-5 days. So, a possible protocol would be to take 100mcg - 200mcg clonidine before bed for 3-5 days to keep cortisol and adrenalin at bay, which should give the body a break and allow for thyroid to take over.
http://www.ncbi.nlm.nih.gov/pubmed/10949540
http://www.ncbi.nlm.nih.gov/pubmed/6302442
http://www.ncbi.nlm.nih.gov/pubmed/4011650
http://www.ncbi.nlm.nih.gov/pubmed/2847928
http://www.ncbi.nlm.nih.gov/pubmed/9579500
http://www.ncbi.nlm.nih.gov/pubmed/11546715
http://www.ncbi.nlm.nih.gov/pubmed/8218604
http://www.ncbi.nlm.nih.gov/pubmed/10949540
http://www.ncbi.nlm.nih.gov/pubmed/6302442
http://www.ncbi.nlm.nih.gov/pubmed/4011650
http://www.ncbi.nlm.nih.gov/pubmed/2847928
http://www.ncbi.nlm.nih.gov/pubmed/9579500
http://www.ncbi.nlm.nih.gov/pubmed/11546715
http://www.ncbi.nlm.nih.gov/pubmed/8218604