Topical Pirfenidone - The real answer to inflammation and fibrosis. Not taurine, MSM, serrapeptase etc

[johnwester130]

A google search for antifibrotic drugs shows nintedanib (Ofev®) and pirfenidone

Interestingly this was picked up on hairlosstalk too

also called KitosCell Gel, probably easier to find.

It works topically, many people use it on scars.

Topical Pirfenidone

I've been researching this chemical for some time now and I think it has its place within a hair loss regimen. "Pirfenidone(AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and...

www.hairlosstalk.com

 

[johnwester130]

This states that finasteride works by inhibiting TGFb 1

Perifollicular Fibrosis and Perifollicular Inflammation in Androgenetic Alopecia — Donovan Hair Clinic

Perifollicular Inflammation and Perifolliuclar Fibrosis are Part of Balding It had long been though that male and female patterned hair loss (‘balding') is a relatively non-inflammatory process. The last decade has repeatedly shown that this is not the case and that inflammation is likely very mu

donovanmedical.com

It’s not entirely clear what causes the perifollicular fibrosis to occur. In 2006, Yoo and colleagues proposed that TGF-beta (transforming growth factor beta) seemed to play a role. They showed that testosterone treatment increased the expression of type I procollagen at mRNA and protein level and this was associated with a rise in TGF-beta protein levels by 81.9 % in dermal fibroblasts. Conversely, pretreatment of finasteride inhibited the ability of testosterone to make pro collagen RNA and protein and decreased the expression of TGF-bet by 30 %. Interestingly, pretreatment of follicles with a TGF-beta antibody inhibited pro collagen expression leading the authors of the study to conclude that testosterone triggers TGF-beta expression and perfiollciular fibrosis in AGA. They also postulate that one mechanisms of finasteride may be to reduce TGF-beta and therefore pro collagen expression. - See more at: Perifollicular Fibrosis and Perifollicular Inflammation in Androgenetic Alopecia — Donovan Hair Clinic

 

[PhilParma]

john, I love your enthusiasm. You have a new "the answer" every couple months. I've put kilograms of weird stuff on my scalp at your behest, and will continue to do so. This stuff is too expensive though.

 

[GenericName86]

I had scars fade when using systemic enzymes, however the scars came back slightly after discontinuing.

I've read T3 also inhibits it. When using T3 my scalp will start to loosen up after a few days and I get the "goosebump/hair standing on end" feeling toward the front of my scalp again when something triggers it rather then just the back of my head. Nicotinamide Riboside also has some effect on fibrosis.

A combination of internal and external treatment would in theory be pretty powerful?

 

[johnwester130]

I had scars fade when using systemic enzymes, however the scars came back slightly after discontinuing.

I've read T3 also inhibits it. When using T3 my scalp will start to loosen up after a few days and I get the "goosebump/hair standing on end" feeling toward the front of my scalp again when something triggers it rather then just the back of my head. Nicotinamide Riboside also has some effect on fibrosis.

A combination of internal and external treatment would in theory be pretty powerful?

There's not that many treatments.

After finasteride, dutasteride, spironolactone, minoxidil, what do you have left?

Micro needling, taurine, zinc?

T3 might help remove the fibrosis and reduce TGF beta 1.

 

[johnwester130]

john, I love your enthusiasm. You have a new "the answer" every couple months. I've put kilograms of weird stuff on my scalp at your behest, and will continue to do so. This stuff is too expensive though.

I agree that I have changed theories a bit too much.

I have never said anything extreme though.

My solutions were based in solid science and based on products already on the market.

This drug is basically taurine but way stronger.

It is very expensive as a gel.
The tablets are cheap though. 2 grams of tablets are 20 pounds. But making a solution out of it could be difficult.

This is basically what massage is doing, reducing the fibrosis. But this is a lot more direct and to the point.

 

[PhilParma]

I'm just teasing. The ideas you bring up are always interesting and your confidence gives me hope.

 

[BrianF]

Interesting stuff yet again, John. Thanks.

 

[BrianF]

I agree that I have changed theories a bit too much.

I have never said anything extreme though.

My solutions were based in solid science and based on products already on the market.

This drug is basically taurine but way stronger.

It is very expensive as a gel.
The tablets are cheap though. 2 grams of tablets are 20 pounds. But making a solution out of it could be difficult.

This is basically what massage is doing, reducing the fibrosis. But this is a lot more direct and to the point.

where you buying this John?

 

[johnwester130]

where you buying this John?

the tablets or kitsoscell?

you can get the powder from china but I don't trust it

 

[BrianF]

The tablets?

 

[johnwester130]

The tablets?

type in pirferidone tablets

and go to google images, not web results,

it will be called united pharmacies

 

[BrianF]

Thanks

 

[Progesterone]

type in pirferidone tablets

and go to google images, not web results,

it will be called united pharmacies

what should I do if I had fibrosis from dermastamping too hard?

getting HT now to fix it... but I have fibrosis all over head from this ***t

 

[johnwester130]

what should I do if I had fibrosis from dermastamping too hard?

getting HT now to fix it... but I have fibrosis all over head from this ***t

it depends how bad the scarring was.

 

[Progesterone]

it depends how bad the scarring was.

Go on...

 

[johnwester130]

Go on...

not sure how to fix fibrosis from microneedling

Lots of thigns can help, topical t3, preg/dhea, topical D3 and k2

 

[Progesterone]

not sure how to fix fibrosis from microneedling

Lots of thigns can help, topical t3, preg/dhea, topical D3 and k2

Do you really think topical T3 can help? or am I better off popping T3 pills?

 

[johnwester130]

Do you really think topical T3 can help? or am I better off popping T3 pills?

topically it has cosmetic effects.

there's lot of info about topical steroids and their beneficial effect

 

[Waynish]

what should I do if I had fibrosis from dermastamping too hard?

getting HT now to fix it... but I have fibrosis all over head from this ***t

Do you think you can dermastamp without getting it? It doesn't look like people get it on their face when doing it to their face... Not that I know anyone who did it to their face, but it is a common "beauty treatment," isn't it?