I think excess cortisol-aldosterone- mineralocorticoid activation trough angiotensin system are main players in balding by cytokine activation and progressing to fibrosis. Focusing on TGF-β₁, which shuts off the anagen phase of the hair cycle, and 11β-HSD₁ expression should fix to the problem...
I have always been suspicious of the massive GERD drug market and the fact that despite them being the most prescribed drugs in the USA, the incidence of esophageal cancer (which they were designed to prevent) has been rising with scary speed. The raw data from the clinical trials on PPI drugs...
"Numerous other inflammatory mediators are produced and potentially secreted into the circulation by adipose tissue (Table 2). Among these, adiponectin (81), resistin (20), acylation-stimulating protein (82), and components of the renin-angiotensin system (83) may be the most important in...