Very good! Thanks for sharing
Thank you for reading!
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Very good! Thanks for sharing
Very good job. Would be very helpful for Peat beginners. I'm reading this forum from a year but not much Peat articles so I clarified some stuff from this summary. You shoud've add red lights as well.
Downloading it. Thanks a lot! Here is another pdf of use:Also, highly recommend you check out his articles. I'll attach a clean pdf collection of his work to this message. It was put together by user PKreb0rn on Twitter.
Downloading it. Thanks a lot! Here is another pdf of use:
Ray Peat interviews with One Radio Network
Ray Peat has been on One Radio Network almost every month since January 2019. That is more than 40 interviews up until now (November 2022). A few months ago I noticed that I often remembered some quote or topic they had talked about, but wasn't able to remember the episode. So I decided to go...raypeatforum.com
Thank you guys for this wealth of information!
Great post!
As someone who has been lurking this forum for a long time, as well as following a lot of twitter "RWBB" and esoteric health accounts, I figure this is a good place to ask some questions I think anyone new to Ray Peat, including myself, might wonder:
-How can saturated fatty acids boost metabolism, when most studies show that in fact PUFA speeds up metabolism, while apparently the opposite is true of SFA?
Effect of dietary fatty acid composition on substrate utilization and body weight maintenance in humans - PubMed
The effect of fat composition of the diet on energy metabolism - PubMed
-How can saturated fat combined with high carbohydrate intake be good, when studies generally show that it increases the incidence of fatty liver, insulin resistance, and cardiovascular problems?
Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat, and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials - PubMed
Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars
Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans
-Can the "non-fattening" effects of SFA be related to the hunger-suppressing effects of SFA compared to PUFA instead of a metabolism boost?
Comparing acute effects of extra virgin coconut oil and extra virgin olive oil consumption on appetite and food intake in normal-weight and obese male subjects - PubMed
I find Ray Peat intriguing, but no explanation for why these mainstream dietary findings could be wrong. Why do all these studies show harmful effects of SFA on energy metabolism and insulin when the claims made by Ray, as far as I understand, are the exact opposite? Is it the combination of SFA with something else in the mainstream diet that causes problems; e.g. PUFA, starch, lack of nutrients, etc. Could the claimed pro-metabolic effects from SFA, be effects that are seen in the longer term while avoiding certain foods and reducing the pro-oxidative effects from PUFAs?
“Animals that lack the unsaturated fatty acids have a higher metabolic rate and ability to use glucose, converting it to CO2 more readily, have a greater resistance to toxins (Harris, et al., 1990; even cobra venom: Morganroth, et al., 1989), including endotoxin (Li, et al., 1990)– preventing excessive vascular leakage–and to immunological damage (Takahashi, et al., 1992), and to trauma, and their neuromuscular response is accelerated while fast twitch muscles are less easily fatigued (Ayre and Hulber, 1996).”
“Many types of evidence indicate that environmental PUFA and prostaglandins produced from the “essential” fatty acids are required for inflammation to progress to degeneration. The n-9 polyunsaturated tatty acids (the kind we can make make from saturated fat or sugar) seems to be positively protective against inflammation. For example, rats fed a diet with 2% hydrogenated coconut oil for two weeks had lower levels of IL-6 and C-reactive protein than when a small amount of arachidonic acid and docosahexaenoic acid (DHA) were added. Mead acid (20:3n9) was lower in the group with the PUFA supplement, and the inflammatory reaction to endotoxin was greater in the supplemented group (Ling, et aI., 2012).
Very informative and excellent for newcomers. Thank you.
This should be pinned as it covers everything nice and concisely for those seeking insight into the Peat process.
Well done.
@Impero, where can I read more about this? Or about other livestock applications of PUFAs or SFAs?[4] Nowadays, farm animals are fed diets very high in PUFAs to fatten them up.
The original experiment Peat often quotes about how pigs who ate coconut oil got leaner was from an older Encyclopedia Britannica article, I believe. You can find several articles about pig/livestock/mammal feed and their effects scattered in the awesome Fire in a Bottle blog. Here's a great summary/guide of some of his work, which I highly recommend because, coincidentally, Brad Marshall (the owner) has a ton of great more in-depth articles on oxidation and how it regulates metabolism. Honestly, I agree that my comment free radicals is very vague. It's by far the weakest part of the article IMO; it's hard to condense all info on PUFAs so much without sounding generic. Besides Brad, I recommend checking out Chris Masterjohn's course on the antioxidant system (he makes a great distinction between oxidative stress and oxidative damage). The first three lessons are free. I'm currently working on a much more extensive intro to Bioenergetics, but I'm only at the start of that journey so far (just 2 articles lol). Hope that helps man.@Impero, where can I read more about this? Or about other livestock applications of PUFAs or SFAs?
Also, I'm still not clear on the mechanisms by which free radicals, or oxidants in general, cause damage?
Even on your substack, it's hard for me to figure out:
"When their double bonds break, the now-free and unstable molecules (called “free radicals”) freak out and try to either steal or give away an electron from any molecules around it to reach a stable state again. In the process, they wreak havoc to all their neighbors, and in their brief (but intense) lifetime can cause mutations to your DNA, resulting in things like heart disease or cancer."
Introduction to Bioenergetics (Appendix)
[1] A quick overview of how ATP is producedimpero.notion.site
It's just a bit vague, and I've had trouble finding out more of this from the usual sources of scientific literature, perhaps because it's considered so basic at this point.
The article showing the fire tornado seems pretty good. The introduction to how oxygen and hydrogen interact with carbon is a good starting point, and I will read further.The original experiment Peat often quotes about how pigs who ate coconut oil got leaner was from an older Encyclopedia Britannica article, I believe. You can find several articles about pig/livestock/mammal feed and their effects scattered in the awesome Fire in a Bottle blog. Here's a great summary/guide of some of his work, which I highly recommend because, coincidentally, Brad Marshall (the owner) has a ton of great more in-depth articles on oxidation and how it regulates metabolism.