Taurine Lowers Homocysteine

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Effect of taurine supplementation on plasma homocysteine levels of the middle-aged Korean women. - PubMed - NCBI

Effect of taurine supplementation on plasma homocysteine levels of the middle-aged Korean women.
Ahn CS. Adv Exp Med Biol. 2009.
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Abstract
The purpose of this study was to evaluate the effect of taurine supplementation on plasma homocysteine (Hcy) levels, an independent risk factor of cardiovascular disease. The subjects consisted of 22 healthy middle-aged women (33 to 54 years). Serum lipids, plasma taurine and plasma Hcy levels were measured before and after supplying 3 g taurine per day for 4 weeks. The concentration of plasma taurine was significantly increased from 63.7 +/- 14.2 micromol/L to 73.8 +/- 16.6 micromol/L after taurine supplementation (p < 0.001). On the other hand, the concentration of plasma Hcy was significantly decreased from 8.5 +/- 1.2 micromol/L to 7.6 +/- 1.1 micromol/L after taurine supplementation (p < 0.05). The effect of taurine on the levels of plasma Hcy was assessed by regression analysis (R2 = 0.304). After taurine supplementation, plasma taurine and Hcy concentration exhibited a significant negative correlation (p < 0.05). In conclusion, taurine is an effective nutrient that antagonizes Hcy levels. Therefore, this study suggests that sufficient taurine intake might be an effective way of preventing cardiovascular diseases, such as atherosclerosis.

 

[Amazoniac]

https://s3.amazonaws.com/academia.edu.documents/41737355/Health_implications_of_creatine_Can_oral20160129-18284-v6sss3.pdf?AWSAccessKeyId=AKIAIWOWYYGZ2Y53UL3A&Expires=1513283322&Signature=y1POQo5CGkLX29XTo55WWYp1eXo=&response-content-disposition=inline; filename=Health_implications_of_creatine_can_oral.pdf#page=9

It has been estimated by Mudd et al. (1980) that Cr biosynthesis accounts for ~70% of the total utilization of ‘labile methyl groups’ (i.e., S-AdoMet) in the body. Based on these data, McCarty (2001) and Steenge et al. (2001) postulated that oral Cr supplementation, by suppressing endogenous Cr biosynthesis, has a sparing effect on S-AdoMet. This might result in activation of cystathionine notburtlanforsure-synthase, would reduce the rate of formation of homocysteine, and might thereby contribute to a lowering of plasma homocysteine levels.

The issues with supplementation are discussed by the end of the review.
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