Momado965
Member
- Joined
- Aug 28, 2016
- Messages
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Thats not hypothyroidism but rather hyper hyperthyroidism. They have low tsh, good t4 and amaizing total t3 levels. The antibiotics improved their levels.
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No just this and a topical antibiotic the name of which escapes me.It might be in part due to hormonal mechanisms that are part of puberty. Acne is caused by prolactin, estrogen excess or by cortisol Messing with androgens - and might be aggravated by suppressing thyroid function / homeostasis through mino even further.
Have you taken retinoid acid - medication also?
Thats not hypothyroidism but rather hyper hyperthyroidism. They have low tsh, good t4 and amaizing total t3 levels. The antibiotics improved their levels.
Only for a time as the study clearly states. Then thyroid function tanks.
You think these drugs were rather responsible for the persistent hypothyroidism?Only one got persistent hypothyroidism and it was after taking methimazole and propanolol..
“Black thyroid” has been noted in patients after a wide range of tetracycline exposure as well as in those who discontinued the drug. Pigment deposition may occur early in the treatment course and represents a permanent alteration in the thyroid [4, 26]. The relatively common finding of “black thyroid” and the potential for thyroid dysregulation has led many authors to call for the routine monitoring of thyroid function in patients taking tetracyclines.
You think these drugs were rather responsible for the persistent hypothyroidism?
In several cases it seems like they only refer to when the thyrotoxicosis resolved without further follow-up, whereas one case developed hypothyroidism 15 months after the thyrotoxicosis resolved, which then took another 2 years to resolve.
Also it seems the blackening of the thyroid is a permanent effect of these drugs, and there is some evidence that this pigmentation does disrupt thyroid function.
That was Case 7.I dont know a lot about methimazole and propanolol but it could be. Where do you see the case with develope hypo 15 monts after ?
I think the blackening is iron chelates. Not sure if its dangerous.
I dont know a lot about methimazole and propanolol but it could be. Where do you see the case with develope hypo 15 monts after ?
I think the blackening is iron chelates. Not sure if its dangerous.
That was Case 7.
If changes in appearance are visible without histologic technology and in plain sight,we have to assume that it is indeed dangerous,and that associations between drug use and permanent damage in consuments are overlooked,underreported and not followed up,and probably quite common.
Reduced thyroglobulin and disruption of lysosomal function sounds quite bad, although she had normal thyroid hormone levels. Can a damaged thyroid gland still produce optimal amounts of thyroid hormone?Abstract
We report on a 37-yr-old woman with known antemortem ingestion of minocyclin who died suddenly from a ruptured cerebral aneurysm. At autopsy, her thyroid gland, although not enlarged, was diffusely black, caused by the deposition of a melanin-like pigment that stained positive with Schmorl's reagent. The pigment could be bleached with permanganate, and on examination by electron microscopy, it appeared to be deposited within the thyrocyte lysosomes. Additional immunostaining with many antibodies revealed an increase in vimentin staining in the follicular epithelium compared with normal control thyroid glands. Staining for cytoplasmic thyroglobulin was markedly reduced, despite normal thyroid indices performed on stored antemortem blood. Stainable ubiquitin in the follicular epithelium appeared reduced compared with control thyroid tissues. These immunohistochemical findings may reflect disruptions of lysosomal transport and function associated with the abnormal accumulation of pigment. This appears to be the only case of minocyclin-associated "black thyroid" in which extensive immunohistochemical investigations have been performed.
Oh, gosh, Tristan. I consider Lugol's iodine one of my pillars of health. Absolutely foundational and I'm one of those with the mystery of chronic illness (and I probably have 10,000 hours of research). I've been on 100mg/day (yes mg, not mcg) for over a decade. The first time I started Lugol's I started with 1 drop, the next day 2 drops, the next day 3 drops, the morning I would've taken 5 drops ..... I was miserable. My salivary glands were aching and over producing and I had a metalic taste in my mouth. I thought I was excreting iodine and assumed I wasn't deficient. But iodine kept coming up in my research. A year later I started again, 1 drop for three day, then 2 for 3 days, etc. (along with cofactors). What I learned is that the first time I started, I couldn't detox fast enough the garbage that the iodine was displacing.how does the thyroid gets repaired,would like to re-nourish my glands!,i do not have much hope that it works though?
So recently I read that oxalate and iodine either take up the same receptor. So I wonder if tetracycline could displace iodine?
Just an ideaWhy that, do you know about a similarity of Tetracyclines and Oxalates or just an idea?
I asked, he was somewhat cryptic as usual though
- What do you think of the so called "Black Thyroid" that can be caused by Tetracycline use? They identified one of these pigments as neuromelanin. Will accumulation of neuromelanin in the thyroid gland impair its function? Some reports link Tetracycline use with persistent hypothyroidism but in these cases there was also treatment with anti-thyroid drugs like propranolol and methimazole
RP: I don’t know of any harmful effects of melanin, unlike other pigments, including lipofuscin. Medical use of antibiotics is usually irrational; maybe this will lead to a product to cure grey hair or vitiligo.