The study author says that this should apply to virtually all auto-immune conditions (including allergies), not just MS. Raising levels of NAD+ in the body both reduced the severity of new disease onset, and also reversed the damage caused by already established disease.
http://www.eurekalert.org/pub_releases/ ... 100114.php
"...The scientists performed pre-clinical trials using experimental autoimmune encephalomyelitis, a pre-clinical model for human multiple sclerosis. They showed that NAD+ can block acute or chronic inflammation by regulating how immune cells, called CD4+ T cells, differentiate. Mice receiving CD4+ T cells along with NAD+ present had a significant delayed onset of disease, as well as a less severe form, therefore demonstrating the molecule's protective properties.
"This is a universal molecule that can potentially treat not only autoimmune diseases, but other acute or chronic conditions such as allergy, chronic obstructive pulmonary disease, sepsis and immunodeficiency," said Stefan G. Tullius, MD, PhD, BWH Chief of Transplant Surgery and Director of Transplantation Surgery Research, lead study author.
Moreover, the researchers demonstrated that NAD+ can restore tissue integrity which may benefit patients that have advanced tissue damage caused by autoimmune diseases. In terms of next steps, ElKhal notes that the lab is currently testing additional pathways and the clinical potential of NAD+."
One of the most reliable methods of raising NAD+ levels in the body is by taking niacinamide. Human doses for raising NAD+ and treating AD and arthritis are in the range 1g-3g daily.
http://www.eurekalert.org/pub_releases/ ... 100114.php
"...The scientists performed pre-clinical trials using experimental autoimmune encephalomyelitis, a pre-clinical model for human multiple sclerosis. They showed that NAD+ can block acute or chronic inflammation by regulating how immune cells, called CD4+ T cells, differentiate. Mice receiving CD4+ T cells along with NAD+ present had a significant delayed onset of disease, as well as a less severe form, therefore demonstrating the molecule's protective properties.
"This is a universal molecule that can potentially treat not only autoimmune diseases, but other acute or chronic conditions such as allergy, chronic obstructive pulmonary disease, sepsis and immunodeficiency," said Stefan G. Tullius, MD, PhD, BWH Chief of Transplant Surgery and Director of Transplantation Surgery Research, lead study author.
Moreover, the researchers demonstrated that NAD+ can restore tissue integrity which may benefit patients that have advanced tissue damage caused by autoimmune diseases. In terms of next steps, ElKhal notes that the lab is currently testing additional pathways and the clinical potential of NAD+."
One of the most reliable methods of raising NAD+ levels in the body is by taking niacinamide. Human doses for raising NAD+ and treating AD and arthritis are in the range 1g-3g daily.