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Your vitamin d level is very low. 48.5 nmol/l = 15.25 ng/ml. Most experts recommend around 50 ng/ml. Suggest you listen to this podcast about Vit D with Georgi. He talks about muscle wasting being one of the first signs of Vit D deficiency.
I jump too quickly on too many supplements. So my focus is now on getting ADKE, calcium, magnesium, sodium, potassium; some B complex, eat liver 1-2 per week, eat some shrimp (I get sick from oysters every time!!) and very slowly build up thyroid (multidose t3 in smaller amounts every couple of hours).
if I consume a lot of sugar, I immediately feel more muscle weakness
Interesting. Would adding more sodium work as well?Ok. That may be too much. You should try to reduce your fluid intake in order to see if it helps further.
My reasoning (which is highly hypothetical):
- the enzyme CYP11A1, also called CYP450scc, is in charge of converting cholesterol: "P450scc is a mitochondrial enzyme that catalyzes conversion of cholesterol to pregnenolone. This is the first reaction in the process of steroidogenesis in all mammalian tissues that specialize in the production of various steroid hormones. " (wikipedia)
- It seems like the transcription factor NFAT5 could have a link with this enzyme, RNA-Seq analysis of high NaCl-induced gene expression:
- "Categories of NFAT5 Target Genes Upregulated after Adaptation to High NaCl, but Not after as Little as 24 h of High NaCl.
- Steroid hormones. Cyp11a1 protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones."
- NFAT5 is downregulated by hypotonicity, which I think could be caused by drinking too much. Note that while it seems like NFAT5 upregulates this enzyme, it could be false to think that by downregulating NFAT5, you would necessarily downregulate its target, the enzyme CYP11A1. Additionally, this is proven in one kind of cell.
Your vitamin d level is very low. 48.5 nmol/l = 15.25 ng/ml. Most experts recommend around 50 ng/ml. Suggest you listen to this podcast about Vit D with Georgi. He talks about muscle wasting being one of the first signs of Vit D deficiency.
Vitamin D helps, but my minerals are all out of whack. Also trying to balance it with A, K and E. However I cannot handle too high A, so that’s why I think I have to be careful with too much D; is that a correct assumption ?Metabolism of vitamin D:
By the way, the enzyme CYP11A1 seems to redirect vitamin D3 towards an alternative form to the classic vitamin D metabolites 25(OH) and 1,25(OH).
I guess that if you have naturally high steroids, then you should have (relatively) high amounts of this form of vitamin D.
Thanks for your kind words! You’re right I have to move things slower. There are also a lot of stressors, like worrying about where this is going, losing my job etc.Bart, when I first started Peating, anything over 1000 mg of calcium a day, divided up throughout the day, caused me frightening shortness of breath. Plus, no matter how much magnesium I was taking in (I was doing watermelon up the wazoo), I kept getting bad foot cramps every night. Anything more than a single baby aspirin a day made me deaf. And even a quarter grain of thyroid without food sent me into a heart-pounding panic attack.
So I just pulled it all back and started adding a single pro-metabolic thing at a time in little eensy teensy doses, and all in the context of a traditional healthy diet. A little meat or fish. A few glasses of milk. Five fruits/veggies a day (mostly fruit, always a piece of watermelon). A little rice at lunch. My homemade sprouted-oats granola with milk and blueberries at bedtime (my comfort food). An oyster in the morning, an oyster at night. (If you can't eat an oyster, eat 1/20th of an oyster.) 1 ounce of liver a day. Some gelatin or high-glycine broth. A little carrot salad most days. A chocolate chip cookie now and then. A minuscule thyroid crumb with food.
Did your mother or grandmother ever cook traditional family recipes for you? I started with eating the meals my great-grandmother from Hungary might have made for me and just slowly Peated it up.
And it just gets better and better. No more shortness of breath if I drink a lot of milk and also have a bunch of cheese in a day. No more foot cramps. No more panic attacks. No more hyperventilation. No deafness from aspirin. More energy, more endurance, temps and heart rate fine.
You're basically doing the right stuff, you know it. Just do it a lot more gradually so you don't overwhelm your existing capability. Try to be your own grandma to yourself. Much love to you.
Thanks for the suggestions, I might give cypro another try, did you multi dose it through the day?I had muscle weakness for the longest time, especially in my arms. The most important things for me to heal from muscle weakness/ muscle wasting were:
-Vitamin D3( 10.000 IU per day for probably 8 or 9 months). I was really deficient in it for a long time. Noticed a big increase in strength after only a week of use.
-Caffeine: 400 mg per day.
-Cyproheptadine: 12 mg per day.
-Thyroid hormone( t3): I can't remember right now how much I was using back then, but I didn't go above 50 micrograms per day( orally).
I think your right about that. What kind of things work best to lower lactate?Sugar makes you weak it's most probably high lactate levels. Do you feel sluggish with sugar? Make blood lactate test it should be very cheap. Here it's 5$. I bet it's lactate.
I guess that it should help :)Interesting. Would adding more sodium work as well?
You're welcome.Thanks for the suggestions, I might give cypro another try, did you multi dose it through the day?
Hey I have not really, thanks for asking. I do know more about what’s going on. I have developed ehler danlos syndrome. Also think I have MCAS. I think I’m having a thiamin deficiency and trying to build it with the other b vitamins ..@Bart1 did you resolve this issue?
I have ehler danlos too although I am not sure I believe it's genetic like they keep telling us. I think I have MCAS which I blame on vaccine adverse reactions. In fact I blame vaccines for a lot of things.Hey I have not really, thanks for asking. I do know more about what’s going on. I have developed ehler danlos syndrome. Also think I have MCAS. I think I’m having a thiamin deficiency and trying to build it with the other b vitamins ..
No I suddenly developed EDS so I don’t buy the “genetic” theory. Vaccines definitely play a bad role yes. Bad gut health, nutrient deficiencies. I also have had EBV, herpes simplex, lyme and other co infections.I have ehler danlos too although I am not sure I believe it's genetic like they keep telling us. I think I have MCAS which I blame on vaccine adverse reactions. In fact I blame vaccines for a lot of things.
Correcting thiamine is a good idea