Dear members,
I’ve been roaming this forum since 2018, since I discovered the work of Peat after experiencing a health crisis extreme tiredness, dizziness(hypothyroid; low temps and low pulse).
Since then I tried a lot of things to get things better snd had a lot of testing done.
Unfortunately, things got worse, way worse.
I’m in a state of muscle wasting. This is going on for about 1,5 years. Since a year walking became more difficult. As the wasting continued, skeletal muscles became softer I started to have muscle weakness etc. I panicked and went to a neurologist, who did a brain and spine mri checking for things like MS. nothing out of the ordinary. Also went to a endocrinologist who found low testosterone and slightly elevated CK levels.
But after a second blood draw, no elevated CK anymore and testosterone was low but in range.
I have a lot of additional information I can provide but I hope someknowledgeably people could provide some suggestions about how to move forward.
i’m 38 years old. I have hemochromatosis discovered about 15 years ago. I have chronically high serum iron and saturation. I have been donating blood to keep ferritin low. But since I understand more of the disease, I try to donate now 5 times a year.
I am pre diabetic, not really overweight. I have a buffalo hump and my neck is tilting forward more snd more.
if I consume a lot of sugar, I immediately feel more muscle weakness.
I’m hypothyroid as well. I take thyroid but have difficulty raising metabolism because I keep running into a stress response and the wasting starts again.
A lot of pro metabolic things excagerate the situation. Simply adding more sugar to meals and b vitamins does not really work.
At this point I am almost not able to walk. My skeletal muscles have atrophied so much. I’m desperate at this point.
some things I think could be the cause
hemochromatosis->hypothyroidism->insulin resistance.
some things I found:
Hypothyroid myopathy typically manifests as polymyositis-like myopathy with proximal muscle weakness and an increased creatine kinase level.
Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis.
Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis. - PubMed - NCBI
Structural and functional modifications occur in skeletal muscle during aging. These defects lead to impairment in muscle strength, contractile capacity and performance. ... Therefore in a more general concept, insulin resistance found in many clinical settings, could be considered as a contributor to muscle wasting.
Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. - PubMed - NCBI
Thus, insulin resistance causes muscle wasting by mechanisms that involve suppression of PI3K/Akt signaling leading to activation of caspase-3 and the ubiquitin-proteasome proteolytic pathway causing muscle protein degradation.
Any help suggestion highly appreciated; I’m desperate, I live in hell atm
I’ve been roaming this forum since 2018, since I discovered the work of Peat after experiencing a health crisis extreme tiredness, dizziness(hypothyroid; low temps and low pulse).
Since then I tried a lot of things to get things better snd had a lot of testing done.
Unfortunately, things got worse, way worse.
I’m in a state of muscle wasting. This is going on for about 1,5 years. Since a year walking became more difficult. As the wasting continued, skeletal muscles became softer I started to have muscle weakness etc. I panicked and went to a neurologist, who did a brain and spine mri checking for things like MS. nothing out of the ordinary. Also went to a endocrinologist who found low testosterone and slightly elevated CK levels.
But after a second blood draw, no elevated CK anymore and testosterone was low but in range.
I have a lot of additional information I can provide but I hope someknowledgeably people could provide some suggestions about how to move forward.
i’m 38 years old. I have hemochromatosis discovered about 15 years ago. I have chronically high serum iron and saturation. I have been donating blood to keep ferritin low. But since I understand more of the disease, I try to donate now 5 times a year.
I am pre diabetic, not really overweight. I have a buffalo hump and my neck is tilting forward more snd more.
if I consume a lot of sugar, I immediately feel more muscle weakness.
I’m hypothyroid as well. I take thyroid but have difficulty raising metabolism because I keep running into a stress response and the wasting starts again.
A lot of pro metabolic things excagerate the situation. Simply adding more sugar to meals and b vitamins does not really work.
At this point I am almost not able to walk. My skeletal muscles have atrophied so much. I’m desperate at this point.
some things I think could be the cause
hemochromatosis->hypothyroidism->insulin resistance.
some things I found:
Hypothyroid myopathy typically manifests as polymyositis-like myopathy with proximal muscle weakness and an increased creatine kinase level.
Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis.
Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis. - PubMed - NCBI
Structural and functional modifications occur in skeletal muscle during aging. These defects lead to impairment in muscle strength, contractile capacity and performance. ... Therefore in a more general concept, insulin resistance found in many clinical settings, could be considered as a contributor to muscle wasting.
Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. - PubMed - NCBI
Thus, insulin resistance causes muscle wasting by mechanisms that involve suppression of PI3K/Akt signaling leading to activation of caspase-3 and the ubiquitin-proteasome proteolytic pathway causing muscle protein degradation.
Any help suggestion highly appreciated; I’m desperate, I live in hell atm