MCTs and Coconut Milk increase bile excretion and activate FXR

[Mauritio]

Another reason to excrete bile quickly is its metabolism by bacteria in the gut. The microbiome reduces bile acids and Im not sure what the consequences of that are (maybe reductive stress?), but Vitamin K avoided that reaction. So another reason to take Vitamin K.

" Unsaturated 4-ene-3-oxo and 1,4-diene-3-oxo bile acids were reduced in Ring A. 5 beta-3-Oxo bile acids were reduced to 5 beta-3-hydroxy bile acids. 4-Ene, 1,4-diene and 4,6-diene-3,17-dioxo-androstanes were reduced in Ring A with concomitant reduction of oxo groups to hydroxyl groups. The Gram-negative facultative anaerobic faecal bacteria are implicated in the reductive process, whilst the genus Clostridium does not appear to be important. Inclusion of menadione, a synthetic form of vitamin K, retards the reductive process."
- Metabolism of unsaturated bile acids and androstanes by human faecal bacteria - PubMed

 

[WonMore]

The coconut milk study also claims that coconut milk's fatty acids activate the FXR ,which is a very interesting and pro-metabolic receptor. Interestingly PUFA antagonize that receptor. And activating FXR decreases PUFA in the liver (Activating FXR decreases PUFA in the liver )



"As expected, the fecal bile concentration of the coconut milk group had increased significantly by1.68-fold,..."
- https://www.ocl-journal.org/articles/ocl/pdf/2020/01/ocl200053.pdf

Don't see anyone pointing this out: sorry @Mauritio but what you wrote here doesn't make sense. FXR is activated by reabsorbed bile, not by excreted. It is part of a feedback loop, which blocks additional production of bile acids, when they are preserved and circulating. So it not seem probable that increased fecal bile acids would correspond with increased FXR. And indeed, the study states:

"Consistently, the bile acid synthetic genes –Cyp7a1, Cyp7b1, and Akr1d1 – were elevated in the liver of coconut-milk-fed mice, in conjunction with a significant down-regulation of the Fxr mRNA (Fig. 1c).Likewise, the Fxr protein level of the coconut milk group was also downregulated significantly (Fig. 1d). This shows that the increased bile acid excretion in the coconut milk group is modulated through the suppression of Fxr. Such changes were not observed in the light cream"

There's nothing about activation of FXR there, as far as I can see.