Low-dose Aspirin As Treatment For Kidney Disease / Failure

[Candeias]

Actually, it is losartan that is known to reverse mitochondrial aging in kidneys and systemically. Telmisartan is used mostly as a doping drug by athletes. I posted a study on losartan on the forum somewhere but telmisartan is probably also a good choice.

Telmisartan is more effective than losartan in reducing proteinuria in patients with diabetic nephropathy



Novel ARB provides greater reductions in proteinuria in diabetics with overt nephropathy

"After one year of therapy with the two ARBs, telmisartan provided greater reductions in the amount of protein in the urine, a finding not attributed to blood-pressure control, as reductions in systolic and diastolic blood pressure were similar in both treatment arms. As per study protocol, after a two-month period in which both drugs were stopped, investigators report a sustained and persistent antiproteinuric effect with the novel ARB.


""At one year, one of the things that is really on the mind of the FDA, as well as on the mind of clinicians, in terms of whether you're actually altering the natural history of disease, is the persistent effect," said Bakris. "So we stopped the drugs at one year and followed the patients for two months to see what would happen with changes in proteinuria. We wanted to know whether everything would come back to where it was a year earlier or would everything stay down.""


The persistent effect of telmisartan was surprising, said Bakris, but could be explained by differences in receptor bindings, duration of action, or lipophilicity between the two agents. With similar levels of blood-pressure control, the longer-acting, higher-binding telmisartan may confer relatively greater protection of ESRD, but that hypothesis needs to be tested in clinical trials, he said."