DaveFoster
Member
Lisuride has mixed serotonergic activity and can cause serotonin syndrome in high dosages or when combined with a serotonergic drug:
"A 75-year-old man developed agitation, confusion, incoordination, and gait disturbance because of progressive rigidity. Mirtazapine had been started 8 days earlier to control major depression. Physical examination revealed diaphoresis, low-grade fever, hypertension, tachycardia, bilateral cogwheel rigidity, hyperreflexia, tremor, and myoclonus, symptoms and signs that are consistent with severe SS."
Reference: http://journals.sagepub.com/doi/abs/10.1345/aph.1A302?journalCode=aopd
Has anyone taken both lisuride and mirtazapine concomitantly with success?
"A characteristic behavioral syndrome has been associated with stimulation of central serotonin receptors in rats. This behavior can be produced by inhibition of monoamine oxidase and administration of 5-hydroxytryptophan as well as by direct acting serotonergic agonists. LSD and the novel ergot derivative lisuirde produced this syndrome in rats. These drugs possess both serotonergic and dopaminergic properties. Since changes in dopaminergic function have also been reported to affect the so-called serotonin syndrome, it was not clear how the two ergot drugs acted to produce this syndrome. The syndrome produced by pargyline and 5-hydroxytryptophan methyl ester was blocked by haloperidol, methysergide, parachlorophenylalanine, and alpha-methylparatyrosine; these treatments failed to block the effects of lisuride. Metoclopramide did not block the syndrome produced by either lisuride or pargyline plus 5-hydroxytryptophan methyl ester. Methysergide partially blocked the behavioral effects of LSD; pretreatment with either haloperidol or metoclopramide potentiated and prolonged the behavioral effects of LSD. The results suggest that dopaminergic modulation of the serotonin syndrome occurs before the serotonin receptor involved in this behavior. Also, the differences between LSD and lisuride may be relevant to their different psychopharmacological properties."
Reference: Lisuride and LSD: Dopaminergic and serotonergic interactions in the “serotonin syndrome”
Mirtazapine has also been shown to cause serotonin syndrome in certain instances:Reference: Lisuride and LSD: Dopaminergic and serotonergic interactions in the “serotonin syndrome”
"A 75-year-old man developed agitation, confusion, incoordination, and gait disturbance because of progressive rigidity. Mirtazapine had been started 8 days earlier to control major depression. Physical examination revealed diaphoresis, low-grade fever, hypertension, tachycardia, bilateral cogwheel rigidity, hyperreflexia, tremor, and myoclonus, symptoms and signs that are consistent with severe SS."
Reference: http://journals.sagepub.com/doi/abs/10.1345/aph.1A302?journalCode=aopd