Intranasal testosterone to restore T levels to high normal range

[Hans]

An interesting study found that just 11mg of T intranasally per day was effective at increasing to the normal high range.

Here is a part of the abstract. I can't get access to the full study.

"The purpose of this study was to develop a single-dose administration protocol using intranasal testosterone that would produce a proportionally similar rise in testosterone for both sexes. We found that an 11 mg intranasal testosterone dose in men and a 0.3 mg dose in women raised testosterone concentrations to the high normal physiological range for each sex, producing similar dose-response dynamics in both sexes." (R)

 

[Lancaster]

There you go bud — will give it a read myself later tonight.

 

[ecstatichamster]

Thank you! Nice find.

 

[Hans]

There you go bud — will give it a read myself later tonight.

You da man! Thanks.

So the increase doesn't seem to be as high at that dose and it goes back to baseline just after 2 hours.

"Based on the EMMs from the best fit model for men, men's testosterone concentration increased by 57% ([6.95 ng/ml − 4.42 ng/ml] / 4.42 ng/ml * 100), 76% ([7.80 ng/ml − 4.42 ng/ml] / 4.42 ng/ml * 100), 77% ([7.82 ng/ml − 4.42 ng/ml] / 4.42 ng/ml * 100), and 46% ([6.47 ng/ml − 4.42 ng/ml] / 4.42 ng/ml * 100), at 15, 30, 60 and 120 min after testosterone administration, respectively."

 

[Ingenol]

11mg is a huge amount of test to be back to baseline after only 2 hours. TRT protocols are usually 100-200 mg/week split into 2-7 doses.

 

[ecstatichamster]

11mg is a huge amount of test; TRT protocols are usually 100-200 micrograms per week split into 2-7 doses.

you are sadly mistaken. They are often very high doses of several hundred milligrams per week.

 

[cupofcoffee]

11mg is a huge amount of test; TRT protocols are usually 100-200 micrograms per week split into 2-7 doses.

TRT doses are in milligrams, not micrograms

 

[Ingenol]

TRT doses are in milligram, not micrograms

Thank you, I was mistaken! Edited.

 

[pyr0maniac]

I know they are referring to a gel in this study, but could one replicate the results by dissolving testosterone base powder in MCT and deliver via a nasal spray? MCT because it is quite thin and would not block the spraying mechanism. Possibly with the addition of Isopropyl Myristate to make it less oily and enhance absorption. Or am I speaking garbage?

 

[Andman]

I know they are referring to a gel in this study, but could one replicate the results by dissolving testosterone base powder in MCT and deliver via a nasal spray? MCT because it is quite thin and would not block the spraying mechanism. Possibly with the addition of Isopropyl Myristate to make it less oily and enhance absorption. Or am I speaking garbage?

in theory it should work, but im not sure if its worth the effort seeing as test base works great via oral and/or transdermal route

 

[golder]

in theory it should work, but im not sure if its worth the effort seeing as test base works great via oral and/or transdermal route

I know it seems a bit superfluous, but I would actually be really keen to see if we could make a nasal solution. Anyone got any ideas of safe ratios, carriers, ingredients to get the right consistency!

 

[Risingfire]

I'm going to experiment with intranasal DHT gel. I'll get back to you folks

 

[cats]

The gel in question is apparently just a mixture of castor oil and apricot seed oil. It's called Natesto DailyMed - NATESTO- testosterone gel

Here's the study cited by the authors for the 11mg dosing of that product SAGE Journals: Your gateway to world-class research journals

 

[Makrosky]

Oh well... I don't have TRT but I am now interested on snorting some DHEA or Androsterone and see what happens since it goes straight into the brain.

 

[miquelangeles]

Oh well... I don't have TRT but I am now interested on snorting some DHEA or Androsterone and see what happens since it goes straight into the brain.

Did you try it? Intranasal DHEA.

 

[Makrosky]

Did you try it? Intranasal DHEA.

Not yet. Too many things to try lol.

 

[MetabolicTrash]

Oh well... I don't have TRT but I am now interested on snorting some DHEA or Androsterone and see what happens since it goes straight into the brain.

I have snorted both and it is the same feel of effects only they come on "stronger" or "heavier" at first likely, kinda like binge drinking booze to get the buzz to swoop in faster.

Snorting DHEA was not too different than just eating it "effects-wise."

Andro snorted was too sedative like -- just made me tired and sluggish/weak. Also dealing with that smell of it in my nose for hours was not ... Enjoyable much to say, but it definitely had some more punch to it snorted vs. just rubbed on skin.

One fantasic thing to consider snorting when in need is aspirin -- at least one good experience there.

 

[Makrosky]

I have snorted both and it is the same feel of effects only they come on "stronger" or "heavier" at first likely, kinda like binge drinking booze to get the buzz to swoop in faster.

Snorting DHEA was not too different than just eating it "effects-wise."

Andro snorted was too sedative like -- just made me tired and sluggish/weak. Also dealing with that smell of it in my nose for hours was not ... Enjoyable much to say, but it definitely had some more punch to it snorted vs. just rubbed on skin.

One fantasic thing to consider snorting when in need is aspirin -- at least one good experience there.

Oh really? Aspirin? haha But you have some USP one or do you use the pharmacy ones? Because those have lots of fillers and additives. Very interesting though. What do you experience with it?

I liked pregnenolone powder intranasally a lot. And also lugol diluted in water.

Thanks for the feedback mate.

 

[golder]

How did pregnenolone and aspirin compare intransally vs orally?

 

[A.R]

Anyone actually try this? I’ve seen somewhere people getting positive results taking insulin intranasally.