A review of the potential interactions between the two vitamins and the potential mechanisms behind the ability of vitamin E (in higher doses) to deplete vitamin K.
http://www.encognitive.com/files/Vitami ... roblem.pdf
Also, the abstract contains this statement:
"...The mechanisms by which vitamin E interferes with vitamin K activity, especially blood clotting, are not known, but hypothetically this interference may involve metabolic pathways. Phylloquinone (K1) must be converted to menaquinone (MK-4, the most potent extrahepatic tissue vitamin K) by truncation of the K1 side chain and replacement with geranylgeranyl."
I am not sure what they mean by "most potent", but it is yet another reference in a scientific study that favors MK-4 over the other forms of vitamin K.
http://www.encognitive.com/files/Vitami ... roblem.pdf
Also, the abstract contains this statement:
"...The mechanisms by which vitamin E interferes with vitamin K activity, especially blood clotting, are not known, but hypothetically this interference may involve metabolic pathways. Phylloquinone (K1) must be converted to menaquinone (MK-4, the most potent extrahepatic tissue vitamin K) by truncation of the K1 side chain and replacement with geranylgeranyl."
I am not sure what they mean by "most potent", but it is yet another reference in a scientific study that favors MK-4 over the other forms of vitamin K.