visionofstrength
Member
Just noticed that Peat's original resveratrol article I first read was not published on raypeat.com, it seems. Instead, it's posted here: http://doctorsaredangerous.com/articles ... l_scam.htmvisionofstrength said:The first article I ever read by Peat was his "Resveratrol is a Scam" article. The article was pirated on another website, without attribution, and so it was that when I searched google for the author of the article, it led me for the first time to raypeat.com. That was a good day for me.
At the time, I was learning about the ability of brown adipose tissue (BAT) to increase body temperature. This article was the first time I had seen Peat (or anyone else) explain the phenomenon in this way:
To me, it seems that if Peat is right about this, all aging or anti-aging mechanisms in animals, whether from diet or C60 fullerenes or living at altitude, can be explained in one general theory of "anti-age-itivity", which might be as simple as: the rate of anti-aging (aa) is related to the mass of the body and the concentration of CO2 in the tissues. What might such a formula be?Ray Peat said:The cells in each organ and tissue of the body are arranged in ways that allow them to make their contribution to the function of the organism, while receiving oxygen, glucose, and regulatory substances in the blood, and maintaining and renewing themselves. Except for the skin, their situation amid other cells assures that they will live in a high concentration of carbon dioxide.
There are proteins (uncoupling proteins, UCP) that cause the mitochondria to increase their consumption of oxygen without increasing their synthesis of ATP. The synthesis of ATP is usually thought of as the main reason for the consumption of oxygen, so the UCP have been assumed to exist to increase heat production. The formation of carbon dioxide is usually thought of as just an unavoidable consequence. UCP proteins, however, exist in situations in which heat production doesn’t seem appropriate (Borecký & Vercesi, 2005; Aguilera, et al., 2005; Gnanalingham, et al., 2005). For example, fasting or calorie restriction increases UCP, tending to cause tissues to consume energy more rapidly. Stress and hypoxia also can increase UCP, suggesting that these enzymes have protective functions.
Increasing the formation of carbon dioxide seems to me to be the essential function of the UCP. Thyroid hormone (T3) increases UCP, and UCP increases the formation of new mitochondria. Increased activity of the UCP is closely associated with increased lifespan. A decreased amount of T3 in tissues during aging corresponds to decreasing mitochondrial function.
Increased CO2 inhibits the formation of lactate, decreases the lipolytic effect of adrenaline, and the lowered energy charge produced by the UCP would prevent the diversion of glucose into other uses.
[spoil][tab=30]aa = mco[sub]2[/sub]
A corollary to this might be a kind of relativity in which anti-aging is the context for an animal's sense of time?? For example, this might explain why when we are hyperventilating, and the CO2 concentration is lower, time seems to "speed up"; while when we are relaxed and the CO2 concentration is higher, time seems to "stand still". When CO2 concentration is higher, since we are aging more slowly (anti-aging is greater) during those moments, time is (relatively) slowing down.
What do you think?[/spoil]