We can now add glycine to the substances that inhibit endotoxin or its effects. The endotoxin antagonism probably explains a good deal of glycine's protective effects on the liver from all sorts of assaults, but especially ethanol/alcohol (which is a known TLR4 agonist).
The in-vivo study used a relatively low dose of glycine (HED of about 1g) and it was effective as endotoxin antagonist even after a single administration.
Glycine modulates cytokine secretion, inhibits hepatic damage and improves survival in a model of endotoxemia in mice. - PubMed - NCBI
Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cells. - PubMed - NCBI
"...CONCLUSIONS: Dietary glycine improved survival rates and liver function in endotoxemic mice by regulating the production of proinflammatory or anti-inflammatory cytokines in liver. It attenuated liver injury by deactivating KCs through inhibiting TNF-alpha secretion and increasing IL-10 production. The downregulative effect of glycine on the endotoxin signaling pathway and TLR4/NF-kappaB/TNF-alpha may be a novel potential mechanism by which glycine inhibits KC activity."
The in-vivo study used a relatively low dose of glycine (HED of about 1g) and it was effective as endotoxin antagonist even after a single administration.
Glycine modulates cytokine secretion, inhibits hepatic damage and improves survival in a model of endotoxemia in mice. - PubMed - NCBI
Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cells. - PubMed - NCBI
"...CONCLUSIONS: Dietary glycine improved survival rates and liver function in endotoxemic mice by regulating the production of proinflammatory or anti-inflammatory cytokines in liver. It attenuated liver injury by deactivating KCs through inhibiting TNF-alpha secretion and increasing IL-10 production. The downregulative effect of glycine on the endotoxin signaling pathway and TLR4/NF-kappaB/TNF-alpha may be a novel potential mechanism by which glycine inhibits KC activity."
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