Travis
Member
- Joined
- Jul 14, 2016
- Messages
- 3,189
I just had to post this somewhere:
He means to say gout instead of "goats."
Just to make sure, I tracked down his reference to prove this was a typo. Maybe someone out there really does use it to treat goats?
Nope. It was a typo. The author was Takahiro Nakayama from Osaka, Japan. I can just picture him telling his colleagues in Asian voice, "Owh yah. That goat-drug. Powerful goat drug."
(I posted this in the Hormone forum because 2-methoxyestradiol also inhibits microtubule synthesis.)
2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site
Involvement of microtubule integrity in memory impairment caused by colchicine (Nakayama)Colchicine, which has been used clinically in the treatment of goats (Hastie, 1991), is a plant-derived alkaloid that binds to tubulin and depolymerizes microtubules...
He means to say gout instead of "goats."
Just to make sure, I tracked down his reference to prove this was a typo. Maybe someone out there really does use it to treat goats?
INTERACTIONS OF COLCHICINE WITH TUBULIN (Hastie)Between the thirteenth and sixteenth centuries Colchicum was used only rarely due to its toxicity, but in the eighteenth century Colchieum use was revived for the treatment of acute gout (Fell and Ramsden, 1967). The active agent colchicine remains today a drug of choice in the therapy of this condition (Roberts et al., 1987).
Nope. It was a typo. The author was Takahiro Nakayama from Osaka, Japan. I can just picture him telling his colleagues in Asian voice, "Owh yah. That goat-drug. Powerful goat drug."
(I posted this in the Hormone forum because 2-methoxyestradiol also inhibits microtubule synthesis.)
2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site