Finally Cured From Post Finasteride Syndrome

Mister

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Another recovery;

Biggest factors probably DHT gel, test gel, hcg, proviron and carnitine imo.


View: https://twitter.com/AlphaGels/status/1755226586947964969


π“π«πžπšπ­π¦πžπ§π­ 𝐏𝐫𝐨𝐭𝐨𝐜𝐨π₯ (πŸ” 𝐦𝐨𝐧𝐭𝐑𝐬):
- BPC157 (intra-nasal & oral)
- 20% DHT gel (inner arms & penile application)
- 20% Testosterone gel (scrotal application)
- HCG (250iu EOD)
- Oral proviron
- Aromasin
- Methyl-DHT
- T3 & NDT
- Injectable L Carnitine
- Intensive gut protocol
- Sleep protocol
- GABA & Dopamine protocol
- Anti-serotonin proton (including Cyproheptadine)
- Dopamine agonist protocol (including metergoline)
- Topical DHEA & Pregnenolone
- Heavy metal & Xenoestrogen detoxification
- Intensive Liver protocol
- Daily cialis micro-dosing
- Micronutrient maxxing
- Red light therapy
- Adaptogen cycling

Distinct Positive changes began becoming noticeable 3 months in which continued to COMPOUND over the next 3 months leading to a π—™π—¨π—Ÿπ—Ÿ π—₯π—˜π—–π—’π—©π—˜π—₯𝗬 after 6 months.
 

Mister

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Someone with PSSD reporting great improvements with Lithium


"90% improvement with lithium carbonate 450 mg"

"I started for a few months with a dose of 450mg once a day. Immediately my erection started working again and I remained on lithium for about 2 months. In the meantime I was taking turmeric and I even thought it was her but it wasn't. I was having a lot of burning sensation due to the lithium and decided to do a gradual reduction and stayed on 75mg for a while longer. Today I haven't taken it for 2 weeks, my sexual functions remain unchanged, with morning erections, libido ok, orgasm ok. It honestly seems that lithium contributes to the rebalancing of neurotransmitters."


Also interesting he took lithium carbonate and not the typical orotate version of lithium...

edit:


View: https://www.reddit.com/r/AccutaneRecovery/comments/15yfand/a_deeper_look_into_lithium/


"I'm less inclined to believe that Orotate is any better at crossing the blood brain barrier than carbonate or chloride. This is often cited because a pioneer of the Orotate formulation found that intraperitoneal injections of Orotate gave a 'three times greater' brain concentration than other formulations. [1] However I've found other studies that don't find any significant difference. This study found that when ingested with food Orotate produced very similar brain concentrations of Lithium as Carbonate or Chloride. [2]"

[1] https://onlinelibrary.wiley.com/doi/abs/10.1111/j.2042-7158.1978.tb13258.x
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1666891/?page=3
 
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Mister

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New vid from Kikel:


Talks about a low dose VPA and Livagen combo and him seeing better results from this combo than high dose VPA or livagen. And of course less side effects this way but probably need to take it longer. VPA is more upstream and Livagen is midstream "epigenetically".

Also talks about these doses: Livagen subq 100 - 300 mcg/day and VPA 250 - 500 mg 1x/day. But says this only "opens the epigenetic door", don't forget taking DHT derivative(s), etc.
 
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Mister

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Another person with PFS reporting improvements from Lithium in comments under article:


"I can attest to the efficacy of lithium for post-finasteride symptoms.

I had been suffering PFS symptoms for a little more than a year. Barely any erections, even with Cialis, general tightness in my groin, testicles pulled up into my body. When I came across the information on this page via reddit, I figured it was worth looking into, but I began taking lithium orotate with zero expectations. In fact, I expected it not to work.

Literally within two or three days, so two or three doses of lithium orotate, I was getting morning erections again *for the first time since stopping finasteride.* The tightness in my groin melted away, my testicles began hanging more naturally again. Everything looked and felt and functioned better.

I’m not entirely cured. My body definitely still does not work the way it did before finasteride. But lithium helped me gain so much of that ground back. I am grateful beyond words to the person working on this and sharing it."
 

bruschi11

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Another person with PFS reporting improvements from Lithium in comments under article:


"I can attest to the efficacy of lithium for post-finasteride symptoms.

I had been suffering PFS symptoms for a little more than a year. Barely any erections, even with Cialis, general tightness in my groin, testicles pulled up into my body. When I came across the information on this page via reddit, I figured it was worth looking into, but I began taking lithium orotate with zero expectations. In fact, I expected it not to work.

Literally within two or three days, so two or three doses of lithium orotate, I was getting morning erections again *for the first time since stopping finasteride.* The tightness in my groin melted away, my testicles began hanging more naturally again. Everything looked and felt and functioned better.

I’m not entirely cured. My body definitely still does not work the way it did before finasteride. But lithium helped me gain so much of that ground back. I am grateful beyond words to the person working on this and sharing it."

I mean lithium is just universal. It’s supposed to work if the body is low in lithium.

Look over at freddd in phoenix rising saying how big lithium is. Lithium is hydrogen. It’s nrf2 when combined with b12. Lithium can ultimately = dopamine if all the other components are around.

And lithium, per freddd, can ultimately = coppper.

Copper + nrf2 = iron metabolism at its core assuming a few other things in place methylation for histidine cysteine gluth methionine. Testosterone for iron availability.

Lithium can help anyone but it’s not step 1.
 

bruschi11

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Also re: PFS. There’s gotta be two types. Or several. Or 100. But probably in the several range.

I realize dht is torture for me. And I honestly think the dht spike after stopping fin is what really did it for me in worst of ways.

DHT killing copper unleashed my Lyme disease. I was on testosterone cream before and during my PFS . Testo cream = all dht.

Copper is what controls Bacteria like Lyme.

Hence the antibiotic recoveries like me in 2017. Heck I was antibiotic and liver health really, herbs, fasting coffee enemas and liver flushing. Rife machine etc.

my first htma in February 2018…. I was doing incredible. What does the htma show? Perfect copper and iron. I had good testo for iron. Good liver and methylation for copper availability.

As I relapsed things changed a lot. Very sad what happened really. It just sucks I wasn’t gbold and couldn’t connect the hormones to nutrients to neurotransmitters like him. Took me years to learn and might be too late.

End of day I think elevated dht is a complete poison long term. And have to wonder if fin changed dht sensitivity and when you get that surge something happens.
 
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Mister

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Was reading more about HDACI's and found some interesting posts.

There are many HDACI's, Vorinostat is interesting and not talked about much. Only found one guy who tried it on propeciahelp (no results but no surprise either since you need something to push you into that androgenic state, taking a hdaci as a monotherapy won't be enoug in most cases imo)

Every heard of "red scrotum syndrome"? Seems Vorinostat cured it for this guy and also seems to help for anxiety:


View: https://www.reddit.com/r/redscrotumsyndrome/comments/1ak0fad/vorinostat_might_cure_this/


Now the interesting part of Vorinostat.

Post from Restoring androgen sensitivity with epigenetic modulators

http://www.ehrs.org/conferenceabstracts/2000marburg/guestlectures/s04-sawaya.htm 1
S4 ANDROGEN RESPONSIVE GENES AS THEY AFFECT HAIR GROWTH
Marty E. Sawaya, MD, PhD, ARATEC (Alopecia Research & Associated Technologies) Clinics & University of Miami School Medicine, Florida, USA.
Androgens have profound affects on scalp hair follicles causing growth inhibitory activity hence, miniaturization of hair follicles in the case of men with Androgenetic alopecia (AGA). In human scalp hair follicles, androgens are thought to be growth inhibitory, whereas on beard and body hair, androgens upregulate hair growth. The biochemical activity and immunohistochemical expression of 5a-reductase isoenzymes type I and II has been assessed in scalp of men with AGA, as well as the cytochrome P-450 aromatase enzyme, androgen receptor (AR), estrogen receptor (ER) alpha and beta. Studies in 10 men with AGA where scalp biopsies are obtained before and after 6 months treatment with finasteride (a specific type II 5a-reductase inhibitor) reveal interesting results with regard to the effects of suppressing DHT and how it affects these androgen associated factors. Differences in expression were found for some of the enzymes as well as transcription proteins, AR, ER-alpha and beta. All scalp biopsies from patients obtained 6 months after finasteride treatment revealed intense upregulation of AR expression in comparison to pre-treatment biopsies of the same patient, whereas ERs were not affected, indicating that AR is very sensitive to the affects of 5a-R type II suppression of DHT. Results suggest that as the hair growth returns in these previously miniaturized follicles, DHT suppression also alters the expression of specific Caspase genes inhibiting programmed cell death, apoptosis. Therefore, we can learn alot about the multiple effects of DHT by looking at its suppression in human scalp hair follicle to gain a better understanding of the many androgen responsive genes involved in hair growth regulation.
The abstract brainbug posted from the EHRS conference mentions AR protein being highly over-expressed in the scalp of patients 6 months after stopping treatment with finasteride.

The studies show an association between the Pura(Pur-Alpha) protein and AR over-expression
and show that AR over-expression can be reduced by increasing Pura levels via epigenetic modulators(acting on the Pura encoding gene itself?) or by introducing Pura-producing DNA into the androgen independent cells.

So, if a key component of PFS is persistent overexpression of androgen receptors, then increasing intracellular Pura levels by whatever means could possibly be a treatment option for PFS.


Now what does Vorinostat do?


http://cancerres.aacrjournals.org/content/68/8/2678#ref-44 11

β€œPurΞ± is therefore a key repressor of AR transcription and its loss from the transcriptional repressor complex is a determinant of AR overexpression”

β€œwe have shown that therapeutic restoration of PurΞ± repressor function with agents that relieve epigenetic silencing can reduce AR transcription”

β€œTreatment of AI cells with the same dose of SAHA (7 ΞΌmol/L) increased PurΞ± and strongly reduced the AR mRNA and protein levels”

SAHA is an HDAC inhibitor, also called Vorinostat.


Vorinostat is a very interesting HDACI, haven't heard many talking about it, not even Kikel. Also seems to be a "safer" one than VPA.

Also great read about HDACI:

View: https://www.reddit.com/r/Nootropics/comments/596gbi/i_wrote_an_article_on_hdac_inhibitors_geared/


Another interesting read; Epigenetic changes from Finasteride.( Demethylation protocol and explanation of Demethylating ENZYMES)

Now another interesting HDACI; Sulforaphane a compound found in Broccoli sprouts. Following study suggest Sulforaphane is just as potent as Vorinostat when it comes to hdaci.


View: https://www.reddit.com/r/Nootropics/comments/zcjzrq/sulforaphane_as_strong_as_clinically_used_hdac/


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737738/

This was the first study to show that a naturally consumed food in humans, namely broccoli sprouts, had such a marked effect on HDAC activity [18]. There was strong induction of histone H3 and H4 acetylation coincident with HDAC inhibition at 3 and 6 h, and whereas HDAC activities returned to normal by 24 h, histone hyperacetylation was evident for at least 48 h (Fig. 4). These findings provided the first evidence that dietary intake of broccoli sprouts, a SFN-rich food, influences HDAC activity in normal circulating blood cells of humans, with a level of HDAC inhibition and histone hyperacetylation equal to, or greater than, that achieved with clinically used HDAC inhibitors, such as vorinostat.

Now this is an interesting post (from 2012) and thread about HDACI by a guy with PFS who is a molecular biologist and former prostate cancer researcher. Definitly worth the read:


He actually tried Sulforaphane and had major improvements.


"I decided to try sulforaphane because you can get it without a prescription and I was able to find a very high quality dietary supplement."

  • Noctural erections started coming back. Whereas previous I would rarely get erections when I went to sleep I started to get them again sporadically. Certainly not to pre-fin levels but much more than previously
  • Erection quality began to improve. This is probably this biggest noticeable change. Post fin I would say I was around 50-60% of the stiffness of pre-fin–when I did get erections they were softer and more difficult to maintain. Now I would say I am at about 80-90%, occasionally reaching close to 100% on good days–and they last for longer.
  • Watery semen–this was also greatly reduced and I would say it is about 60-70% of what I would consider normal
  • Morning erections are more consistent
  • Spontaneous erections are also more frequent. Pre-fin I would get spontaneous erections ~5-8x a day. Post-fin it was virtually 0. I would estimate now I’m at 2-3.
The guy made one last update and said he was feeling much better and completely satisfied, even forgot he had pfs so almost recovered. The only missing piece in his theory (although he did speak of using testoserone while on a hdaci in his theory but seems he only tried sulforaphane monotherapy himself) that he needed to, like I said in earlier posts, to push him into that "androgenic" state, a hdaci by itself is not enough in most cases. He did say he lived healthy and went to the gym and was lifting so could be that that was enough for him to get into that androgenic state and thus Sulforaphane helped but again don't think lifiting is enough for most.

(Btw, using a hdaci could also potentially make you worse imo if you're not living healthy, taking dangerous compounds, etc... I'm just theorizing but this could also be what triggered PFS. We took finasteride and maybe were also eating something that had hdaci ability or were in a bad and unhealthy environment, stress,... that openend our "epigenetic door" and thus pushed us into this long term PFS state.)

So besides Lithium and VPA, many other interesting and potent HDACI's exist like vorinostat, sulforaphane and berberine,...
 
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Mister

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List of HDACI's:

8I1q3gf.jpeg

(SAHA: Vorinostat)

List of natural HDAC modulators:

afbeelding.png



Of course many other HDACI's than these. (also note some of these compounds could be anti androgenic too, so do your due dilligence. For example found a guy getting FPS from curcumin; Testosterone Crash with CUCURMIN and Building it up again from Scratch )
 
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Mister

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Vorinostat also helps against fear issues it seems.

I read some similar testimonies about hdacs on longecity, the dudes there claim that even a small of dosage of 1 or 2 pills in a 2 month cycle cure their social anxiety.The hdac that mentioned was vorinostat.
Yes, a few years ago. It totally eliminated all my fears, also from childhood, and it boosted my memory like there was no tomorrow. Very small amounts were needed. Sensational stuff.
 

Mister

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@TTorque Yeah the estrogen theory is interesting, haven't seen many recoveries with it though. Btw if you come across recoveries or something else interesting post it itt.

And we have another recovery in the PFS whatsapp group.

Clomid and turkesterone helped him. Will ask him more details.

Naamloos.png
Guy I was talking about in this older post made a recovery post on reddit.


View: https://www.reddit.com/r/FinasterideSyndrome/comments/1aw77gs/cured/


Seems he was also taking NAD+ and PEA.
 

Mister

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New Kikel post about Mtren. Seems to have quite some success with it for PFS.

 

golder

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New Kikel post about Mtren. Seems to have quite some success with it for PFS.

Methylated Trenbolone? Wouldn’t this be one of the most nephrotoxic and living burdening compounds on the planet? Not to belittle it if it genuinely works, PFS is horrible and wouldn’t wish it on my worst enemy. Anything that works is definitely worth discussing!
 
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Mister

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Methylated Trenbolone? Wouldn’t this be one of the most nephrotoxic and living burdening compounds on the planet? Not to belittle it if it genuinely works, PFS is horrible and wouldn’t wish it on my worst enemy. Anything that works is definitely worth discussing!
Yes it's definitely one of the most dangerous steroids out there. Would definitely not take this without any proper guidance from a professional or someone with a lot of experience dealing with this. It's very liver toxic even at low dosages.

TUDCA is a necessity if you're going to take this imo. Speaking of TUDCA, saw an interesting thread on propeciahelp recently;


Had all kinds of improvements, this especially interesting: "Sperm is thick and white again like before PFS and no longer pure water."
 
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Mister

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New PFS recovery from Kikel:


Used things like 9MBC, carnitine, forskolin and low dose HCG, TRT, DHB locally applied and also high dose Masteron and primobolan.
 

VladSokolov

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Has anyone combined HCG and Oxytocin while on TRT? Oxytocin increases 5 alpha reductase and hence DHT. I saw that Kikel recovered a female using oxytocin, and there was another case (trying to find it again) with recovery using hcg + oxytocin.

Oxytocin increases 5alpha-reductase activity of human prostate epithelial cells, but not stromal cells​

Oxytocin increases 5alpha-reductase activity of human prostate epithelial cells, but not stromal cells - PubMed

Evidence for the regulation of prostatic oxytocin by gonadal steroids in the rat​


Also, healthy microbiome is needed to produce oxytocin.


View: https://www.youtube.com/watch?v=mJm0e_7gdcE

I wonder if we'd need a combination of nasal spray and local injection Oxytocin to be effective.

Additionally...I noticed when I tried the 250IU HCG protocol, I was getting pain in my liver. The study below states LH/hcg reduces 5 alpha reductase type 2 in women's skin (what if this is happening in certain tissues as well in males?).

Luteinizing hormone and human chorionic gonadotropin decrease type 2 5 alpha-reductase and androgen receptor protein levels in women's skin​

Luteinizing hormone and human chorionic gonadotropin decrease type 2 5 alpha-reductase and androgen receptor protein levels in women's skin - PubMed


1710097721362.png



This would make sense why some see improvement, others doesn't (I'm not impressed by the recovery record of 250IU hcg for 6 months). What if we need to upregulate 5 alpha reductase type 1 and type 2, but unfortunately common protocols are increasing one, but blocking the other... That's why I say a combination of HCG and oxytocin may be needed (may need to rotate one then the other). A promising protocol may be TRT (increase T and estrogen) + DHT + pregnenolone + DHEA + hcg + oxytocin. Btw, I think this is very much a paracrine disorder and transdermal TRT and DHT are preferable.

Make that TRT + DHT + pregnenolone + DHEA + hcg + oxytocin + BPC157 (oral) + TB500 + Epitalon.


View: https://www.youtube.com/watch?v=HWcmPZ1oI58


View: https://www.youtube.com/watch?v=l2Gipid6jR4
 
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Mister

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New PFS recovery from Kikel:


Used things like 9MBC, carnitine, forskolin and low dose HCG, TRT, DHB locally applied and also high dose Masteron and primobolan.
Another recovery in comments of this instagram post:

pfsrecover.png



@VladSokolov Interesting post.

I've found one guy on propeciahelp that tried taking Oxytocin but seems it didn't help: Oxytocin , but seems he only took it as a monotherapy maybe in combination with other things like you said it can help.

Could also be that raising allopregnenalone is enough for oxytocin, so taking PEA should help in that regard. (Allopregnanolone modulates oxytocin in hypothalamic OT)

But oxytocin is definitely a crucial part; Scientists identify hormone potentially linked to hypersexual disorder
 
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VladSokolov

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Another recovery in comments of this instagram post:

pfsrecover.png



@VladSokolov Interesting post.

I've found one guy on propeciahelp that tried taking Oxytocin but seems it didn't help: Oxytocin , but seems he only took it as a monotherapy maybe in combination with other things like you said it can help.

Could also be that raising allopregnenalone is enough for oxytocin, so taking PEA should help in that regard. (Allopregnanolone modulates oxytocin in hypothalamic OT)

But oxytocin is definitely a crucial part; Scientists identify hormone potentially linked to hypersexual disorder

Is this an actual recovery though if he needs TRT and is not sure if he is 100%? I was hyper sexual before PFS, my grandfather was supposedly still horny as hell at 80. Not to be a downer, but I'm not sure some of these recoveries are true 100% reversal of PFS/PSSD/PAS. JoeKool, Brongfogboy, etc. those sound legitimate. They're off everything and you an tell they feel 100% back to normal. Also, where are all these Alex Kikel recoveries? Has anyone that personally worked with him actually posted? There are some people on Reddit that say he didn't help then just asked for more money.
 
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