Biotin Restores Glucose Metabolism Even In Type I Diabetes

[lexis]

post 103280 I remember reading a few biotin+chromium picolinate studies similar to this. Would the mechanism for restoring glucose metabolism just be biotin's suppression of FFA since niacinamide and aspirin have shown the same?

No, biotin does more than suppress FFA. It also restarts the Krebs cycle's usage of pyruvate when the cell is stuck in excess glycolysis. So, instead of the cell producing lactate biotin forces the utilization of pyruvate by the Krebs cycle and later by the electron transport chain. The Krebs cycle stimulation is done by enhancing the activity of pyruvate carboxylase and thus preventing the building of pyruvate and eventually lactate. With niacinamide also lowering excessive FFA and raising the levels of NAD (needed for oxidative metabolism), and thiamine stimulating pyruvate dehydrogenase these 3 vitamins are key for maintaining oxidative metabolism even in sick people. I would add pyridoxine / P5P to the group as it was shown to benefit glycolytic and hyperglycemic states as well and it is a cofactor for some of the enzymes in the Krebs cycle. So, a combination of thiamine, niacinamide, pyridoxine / P5P, and biotin should restore oxidative glucose metabolism, provided the electron transport chain is not blocked by something like excessive NO. But methylene blue can take care of the latter

Biotin also increases ATP.Will this have a positive effect on steroid synthesis?

 

[haidut]

post 103926

post 103280 I remember reading a few biotin+chromium picolinate studies similar to this. Would the mechanism for restoring glucose metabolism just be biotin's suppression of FFA since niacinamide and aspirin have shown the same?

No, biotin does more than suppress FFA. It also restarts the Krebs cycle's usage of pyruvate when the cell is stuck in excess glycolysis. So, instead of the cell producing lactate biotin forces the utilization of pyruvate by the Krebs cycle and later by the electron transport chain. The Krebs cycle stimulation is done by enhancing the activity of pyruvate carboxylase and thus preventing the building of pyruvate and eventually lactate. With niacinamide also lowering excessive FFA and raising the levels of NAD (needed for oxidative metabolism), and thiamine stimulating pyruvate dehydrogenase these 3 vitamins are key for maintaining oxidative metabolism even in sick people. I would add pyridoxine / P5P to the group as it was shown to benefit glycolytic and hyperglycemic states as well and it is a cofactor for some of the enzymes in the Krebs cycle. So, a combination of thiamine, niacinamide, pyridoxine / P5P, and biotin should restore oxidative glucose metabolism, provided the electron transport chain is not blocked by something like excessive NO. But methylene blue can take care of the latter

Biotin also increases ATP.Will this have a positive effect on steroid synthesis?

Of course, ATP is a co-factor in several of the steps, as is NAD. NAD and ATP levels correlate almost perfectly (~0.946), so taking niacinamide or methylene blue is perhaps the quickest and most legitimate way to raise ATP by raising NAD.

 

[aussiedownunder]

Does that mean Biotin should be good for PCOS do you think? Since it has links to diabetes?what proportions for the other B's ? I read somewhere it shouldn't be taken alone in high doses.Thank you for all your info.

 

[aussiedownunder]

Also, since my glycogen stores must be non existent (I have the adrenaline rush at 3am ) and early morning ) ( low carbs- no fruit or sugar for nearly two years!) , this may help restore it do you think ?

 

[haidut]

post 104020 Also, since my glycogen stores must be non existent (I have the adrenaline rush at 3am ) and early morning ) ( low carbs- no fruit or sugar for nearly two years!) , this may help restore it do you think ?

Biotin seems to work for glycogen storage and high blood sugar. I don't know if it can help PCOS but I also don't see why it would hurt.

 

[NathanK]

Моля (it means you are welcome). I see you've been brushing up on your Eastern European languages. Where do you hail from?

ha, I've lived in many countries, but you can thank my Cyrillic to google search

 

[poilochio]

post 103223 The glucose and lipid lowering effects of biotin are well known. A combination of biotin and chromium picolinate is approved as a drug for type II diabetes. The study below goes a step further. It mentions that in humans, 16mg of biotin daily for a week restored glucose metabollism in insulin-dependent patients for whom insulin therapy had been withdrawn. In other words, biotin effectively substituted for insulin therapy. In addition, the study replicated the reported results in humans by using a genetically diabetic mouse model. The biotin doses used in the mouse study were equivalent to 15mg and 30mg per day for a human, with the 30mg daily having stronger effect on lowering blood glucose and lowering hyperinsulinemia.
So, people here struggling with glucose issues can try biotin for a week, or a combination of biotin, pyridoxine, thiamine, niacinamide and riboflavin as they are all involved in glucose metabolism. I don't think it gets any better than that, as I don't know of any drug that acts as fast as biotin (1 week) and with such beneficial effects.

http://www.ncbi.nlm.nih.gov/pubmed/3280936
"...Because biotin treatment may lower blood glucose in insulin-dependent diabetes, we chose to study such an effect in non-insulin dependent diabetes. Twenty-six diabetic KK mice, moderately hyperglycemic and insulin resistant, were treated for 10 weeks: 9 animals with 2 mg of biotin/Kg, 8 with 4 mg of biotin/Kg, and 9 with saline (controls). Blood glucose levels, oral glucose tolerance, insulin response to oral glucose, and blood glucose decrease in response to insulin were quantitated. Compared to controls, biotin treatment lowered post-prandial glucose levels, and improved tolerance to glucose and insulin resistance. Serum immunoreactive insulin levels in biotin treated mice were like the controls."

"...Relationships between vitamin status, glucose metabolism and insulin have been demonstrated in animals and humans (1). Vitamin B6 deficiency induces intolerance to glucose (2-5). Treatment with pharmacological doses of B6 improved carbohydrate tolerance in gestational diabetic women (6,7) and in women taking oral contraceptives (8). Riboflavin lowers or increases fasting blood sugar levels in riboflavin-deficient dogs (9-11): intake of high doses of vitamin C appears to be diabetogenic (1). Glucose tolerance is impaired in vitamin A-deficient rats (12). Biotin deficiency has been linked to hyperglycemia and decreased utilization of glucose (13-15). High-dose biotin (16 mg/day) for one week lowered fasting blood glucose levels in non-biotin deficient, insulin-dependent diabetic patients when insulin was withdrawn during biotin administration (16). Because biotin treatment may lower blood glucose levels in insulin-dependent diabetes, we initiated a further study on such a biotin effect in noninsulin-dependent diabetes."

Ok i recieved my Biotin today from Swansson

i will start the test tomorrow 15mg to see how it affects my BS (im a typ 1 Diabetic)

I will continue with my other"peaty"Supplements (B1,B3,Mag , Glycine etc.) as well

 

[Makrosky]

So, a combination of thiamine, niacinamide, pyridoxine / P5P, and biotin should restore oxidative glucose metabolism

Energin ? Although biotin dose is low in it.

 

[haidut]

post 104366

So, a combination of thiamine, niacinamide, pyridoxine / P5P, and biotin should restore oxidative glucose metabolism

Energin ? Although biotin dose is low in it.

Yes, Energin would be fine too. I just didn't want to sound like I am pushing a supplement, and also for some people a higher dose biotin may be needed (just like you mentioned).

 

[Nwlifter]

Nice discussion. New here, just found you guys, I'm a pre-type 2, going to try that biotin idea, just bought some today :)
I'll post my results also, fingers crossed!

 

[Peata]

Did anyone continue with Biotin and have a report on their health?

 

[Peata]

From another study - optimal doses of biotin for lowering glucose and increasing glycogen synthesis seem to be in the range 15mg - 20mg per dose. Higher and lower doses have less of an effect. This dose can be taken several times a day but even once daily was enough to reverse insulin resistance and type II diabetes. Optimal effect are seen within a month but are apparent even after 24 hours.

Thanks for keeping us informed like you do.

I just started Biotin today, 15 mg. per dose. I will take it 2 x day. I feel I have tried everything else to get my body to use sugar properly, so hoping I have something positive to report in a week.

Also to note: I eat low fat, med/high protein, high carb; supplement niacinamide, cyproheptadine, taurine, b1 and a little bcomplex. I get around 400 mg. caffeine.

 

[haidut]

Thanks for keeping us informed like you do.

I just started Biotin today, 15 mg. per dose. I will take it 2 x day. I feel I have tried everything else to get my body to use sugar properly, so hoping I have something positive to report in a week.

Also to note: I eat low fat, med/high protein, high carb; supplement niacinamide, cyproheptadine, taurine, b1 and a little bcomplex. I get around 400 mg. caffeine.

I also posted a study showing 5g - 6g glycine reduces the glycemic response to glucose by over 66%. No wonder gelatin was used for diabetes 100 years ago.
https://raypeatforum.com/community/...hromium-may-be-carcinogenic.9171/#post-119555

 

[Orion]

Supplemented with biotin in the past, and it can increase sebum production drastically. Anyone know what the cause would be?

People with acne, biotin can be negative.

My health was way worse back then, so might be something I would try again.

 

[Orion]

One other thing, off topic but related to biotin.

It seems with me, things that lower FFA's, biotin, niacinamide, and aspirin, always cause breakouts. I wonder what the mechanism is or ties to acne.

Locking up FFA's increases sebum somehow?

 

[Peata]

One other thing, off topic but related to biotin.

It seems with me, things that lower FFA's, biotin, niacinamide, and aspirin, always cause breakouts. I wonder what the mechanism is or ties to acne.

Locking up FFA's increases sebum somehow?

I don't know but I have seen mention of biotin increasing acne for others (just random stuff online). I definitely don't want more acne, but I'm going to risk it for now - at least a week - to see how my glucose response goes.

 

[Orion]

I don't know but I have seen mention of biotin increasing acne for others (just random stuff online). I definitely don't want more acne, but I'm going to risk it for now - at least a week - to see how my glucose response goes.

I saw a massive sebum increase in just a couple days of taking biotin. But this was May 2015, since starting to use Peat's ideas in October 2015 I may have a different response now. Being somewhat better at oxidizing sugars must be part of the puzzle.

 

[Orion]

Picked up some high dose biotin tonight, will try over the weekend and report back on skin and overall feeling.

 

[Peata]

No increase in oil or acne for me so far.

 

[charmer]

I have issues with glucose too. Tried biotin at around 3o mg twice a day at first, then narrowed down to 3omg a day after about 2 weeks. I took it together with 0.5-1g of Niacinamide. What can I say - I started feeling lovely. Much more positive and sane. Initially, biotion provoked a big headache, I was worried it would continue, but I read that people slowly uped their dose to go around it. I made a pause for a few days, and it went away. Feel so much better since.

Another side of things, I had my feet hardening for a while, getting pedicures didn't help much. I know diabetics often report this sort of thing. The problem is gone, I almost have baby feet again (well, feet are very soft and don't really need grooming).

I ran out of niacinamide, and I would say the effect from biotin diminished, not feel as emotionally stable any more. But I have been through a rough time lately and caught a flu, so this conclusion might just be bogus.