Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomes - PubMed
Acetylsalicylic acid (aspirin) is a common nonsteroidal anti-inflammatory drug used for treatment of pain and arthritis. In the body, acetylsalicylic acid is rapidly deacetylated to form salicylic acid. Both compounds have been proposed as anti-inflammatory agents. Major metabolites of salicylic...
pubmed.ncbi.nlm.nih.gov
"All UGTs tested, except 1A4, 2B15, and 2B17, catalyzed salicylic acid phenolic and acyl glucuronidation. Ratios of salicylic acid phenolic to acyl glucuronide formation varied more than 12-fold from 0.5 for UGT1A6 to 6.1 for UGT1A1. These results suggest that all UGTs except 1A4, 2B15, and 2B17 might be involved in the glucuronidation of salicylic acid in vivo."
I came across this study by chance and found that glucuronic acid is involved in the deactivation of aspirin metabolites. Glucuronic acid can also safely remove PUFA from the body, and @haidut previously mentioned that this is a safe way to deplete PUFA. Now I can try to explain a number of paradoxical side effects that people can observe from taking aspirin. Such as hair loss. I think that glucuronic acid is used to deactivate the aspirin metabolites instead of deplete the pufa, what can lead to the accumulation of pufa and side effects.
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