I have a question surrounding Apigenin & CYP3A4, and I was wondering if anyone has any experience taking Apigenin with other medications. There's not a lot of studies or information online regarding how Apigenin may interact with other drugs, but from what I've found CYP3A4 oxidizes small foreign organic molecules (xenobiotics), such as toxins or drugs, so that they can be removed from the body, and Apigenin may inhibit this process which could result in toxic levels of prescription drugs been enhanced in the blood.
''Out of the 30 flavonoids tested, 7 significantly inhibited CYP3A4, most prominent being acacetin that inhibited 95% of enzyme activity at 1 µM concentration. Apigenin showed reversible inhibition, acacetin, and chrysin showed combined irreversible and reversible inhibition while chrysin dimethylether, isorhamnetin, pinocembrin, and tangeretin showed pure irreversible inhibition. These results alert on possible flavonoid⁻drug interactions on the level of CYP3A4.'' The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme - PubMed
Grapefruit juice is a known CYP3A4 inhibitor so do you guys think it would be wise to avoid any CYP3A4 inhibitors when taking NSAIDs for cancer for example? I'm only querying this as I'm new to the forum and most information around Apogenin says it's safe and it's an anti-cancer substance, maybe I'm misinterpreting something here.
Thanks for reading and I appreciate any replies.
''Out of the 30 flavonoids tested, 7 significantly inhibited CYP3A4, most prominent being acacetin that inhibited 95% of enzyme activity at 1 µM concentration. Apigenin showed reversible inhibition, acacetin, and chrysin showed combined irreversible and reversible inhibition while chrysin dimethylether, isorhamnetin, pinocembrin, and tangeretin showed pure irreversible inhibition. These results alert on possible flavonoid⁻drug interactions on the level of CYP3A4.'' The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme - PubMed
Grapefruit juice is a known CYP3A4 inhibitor so do you guys think it would be wise to avoid any CYP3A4 inhibitors when taking NSAIDs for cancer for example? I'm only querying this as I'm new to the forum and most information around Apogenin says it's safe and it's an anti-cancer substance, maybe I'm misinterpreting something here.
Thanks for reading and I appreciate any replies.