thyrulian
Member
- Joined
- Mar 20, 2015
- Messages
- 114
http://www.ncbi.nlm.nih.gov/pubmed/14757778
But fret not! Our ever-reliable (and in no way ever harmful) buddies acetylcholine and nitric oxide can protect us!
But... hang on, surely our bestie's got our back!?
[Estrogen] found to "protect" against "harmful" effects of fructose
Yes! I knew it!
Hyperinsulinemia and insulin resistance are closely associated with hypertension in humans and in animal models. Gender differences have been found in the development of hypertension in fructose-fed rats. The objectives of the present study were, first, to clarify whether androgens are required in the development of hyperinsulinemia, insulin resistance, and hypertension in fructose-fed rats, and second, to determine if cyclooxygenase-1 and cyclooxygenase-2 are also increased in the arteries of these rats. Male rats were gonadectomized or sham-operated and fed a 60% fructose diet beginning at age 7 weeks. Blood pressure was measured by a tail-cuff method, and an oral glucose tolerance test was performed to assess insulin sensitivity after 8 weeks of fructose feeding. Cyclooxygenase-1 and cyclooxygenase-2 mRNA expression was also assessed in the thoracic aortae and mesenteric arteries. Gonadectomy prevented hypertension from developing in the fructose-fed rats, but hyperinsulinemia and insulin resistance developed. There was an increase in cyclooxygenase-2 expression in the thoracic aortae and mesenteric arteries of the fructose-fed sham-operated rats while the expression of cyclooxygenase-1 remained unchanged. Gonadectomy prevented the mRNA overexpression of vascular cyclooxygenase-2 in the fructose-fed rats. These results suggest that the presence of androgens is necessary for the development of fructose-induced hypertension. Androgens apparently act as a link between hyperinsulinemia/insulin resistance and hypertension in fructose-hypertensive rats. Furthermore, an increase in the expression of cyclooxygenase-2 is implicated in the development of hypertension. The mechanisms involved require further study.
But fret not! Our ever-reliable (and in no way ever harmful) buddies acetylcholine and nitric oxide can protect us!
But... hang on, surely our bestie's got our back!?
[Estrogen] found to "protect" against "harmful" effects of fructose
Yes! I knew it!