Mauritio
Member
- Joined
- Feb 26, 2018
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Even a mild Vitamin A deficiency decreases DHEA and Pregnenolone formation by about 40% in rats.
Not surpsing, since Vitamin A is needed for the enzyme that converts cholesterol into pregnenolone ( Vitamin A deficiency impairs gonadal steroid synthesis)
Even more evident was the effect on androstenedione, which suggests that the important enzyme 3bHSD was not working anymore (3β-Hydroxysteroid-Dehydrogenase – Wikipedia)
In the testes the conversion was more than 4 times lower when the animals experienced an "acute Vitamin A deficiency".
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1264968/?page=1
Not surpsing, since Vitamin A is needed for the enzyme that converts cholesterol into pregnenolone ( Vitamin A deficiency impairs gonadal steroid synthesis)
Even more evident was the effect on androstenedione, which suggests that the important enzyme 3bHSD was not working anymore (3β-Hydroxysteroid-Dehydrogenase – Wikipedia)
In the testes the conversion was more than 4 times lower when the animals experienced an "acute Vitamin A deficiency".
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1264968/?page=1