nad

  1. haidut

    PUFA peroxidation can cause heart failure, latter can be reversed

    The mainstream view on heart failure is that in most cases (when it is not congenital) it is a secondary morbidity caused by conditions such as diabetes, CVD, obesity, smoking, alcohol intake, etc. However, a direct causative agent and process has not been proposed so far. The study below...
    • haidut
    • Thread
    • aldehyde aldehyde dehydrogenase aldh androgen estrogen heart failure nad peroxidation pufa
    • Replies: 0
    • Forum: Scientific Studies
  2. haidut

    HIV-1 Breakthrough: niacinamide as a possible treatment

    The study does not claim a cure but it is a direct corroboration of human trials with HIV-1 patients conducted back in the early 1990, as those trials used high dose niacinamide (3g daily) and found improvement in the general condition of the patients. The mechanism of actions was, again...
    • haidut
    • Thread
    • aids hiv hiv-1 nad niacinamide nicotinamide nmn vitamin b3
    • Replies: 1
    • Forum: Scientific Studies
  3. haidut

    Niacinamide may treat Parkinson Disease (PD)

    A very interesting study, which used a relatively high dose of nicotinamide riboside (NR) to treat Parkinson Disease (PD). The dosage used was 3,000mg daily for 4 weeks and it resulted in improvement of motor and cognitive symptoms of PD, while producing no side effects. The study references...
    • haidut
    • Thread
    • metabolism nad nad/nadh niacinamide nicotinamide riboside oxphos parkinson vitamin b3
    • Replies: 9
    • Forum: Scientific Studies
  4. haidut

    Human trial - niacinamide may treat Alzheimer Disease (AD)

    One of my first posts on the topic of bioenergetics - more than a decade ago - was in regards to a promising animal study with the human-equivalent dose (HED) of 30mg/kg niacinamide (NAM) daily showing robust effects on that animal species' model of AD. The authors of the animal study followed...
    • haidut
    • Thread
    • alzheimer dementia nad niacinamide nicotinamide oxphos
    • Replies: 8
    • Forum: Scientific Studies
  5. haidut

    NAD+ deficiency causes kidney disease, niacinamide prevents it

    Chronic kidney disease (CKD) is one of the most prevalent complications of obesity and diabetes. Its causes, as usual, are "unknown" according to mainstream medicine but high glucose levels and genetic predisposition are thought to play a role. Many studies have called into question these...
  6. haidut

    Niacinamide may prevent neurodegeneration

    Yet another study demonstrating that maintaining high energy levels through OXPHOS is crucial for health, in this case brain health. There are many studies, going back decades, demonstrating that a drop in NAD+ levels, and thus of NAD/NADH and, consequently, of OXPHOS is a common feature of...
    • haidut
    • Thread
    • autophagy nad neurodegeneration niacinamide nicotinamide parp sirtuin vitamin b3
    • Replies: 6
    • Forum: Scientific Studies
  7. haidut

    Vitamin B3 counteracts (cancer) cachexia, by restoring NAD+ levels

    As many of my readers know, the majority of cancer patients do not succumb from the actual tumor burden, but as a result of (usually in that order) cachexia, immunocompromise from radiation/chemotherapy, hospital-acquired infection, and/or cytokine storm after surgery for removing the tumor. Of...
    • haidut
    • Thread
    • autophagy cachexia cancer nad niacin niacinamide vitamin b3
    • Replies: 11
    • Forum: Scientific Studies
  8. Mauritio

    Increasing NAD lowers body weight, cholesterol and blood pressure

    In this study they gave middle aged people "2 MIB-626 tablets each containing 500 mg of microcrystalline β-nicotinamide mononucleotide or placebo twice daily for 28 days." Most notably the participants lost about 1.9kg of body weight in just 28 days. Now was all over that fat ? Hard to say...
    • Mauritio
    • Thread
    • blood pressure cholesterol nad nad+ nad/nadh nicotinamide mononucleotide weight loss
    • Replies: 38
    • Forum: Scientific Studies
  9. Mauritio

    Microdosing nicotine increases NAD levels and rejuvenates old mice

    This study looked at the effect of microdoses (2 μg/mL drinking water) of nicotine on mice. Nicotine was able to rescue the rate limiting enzyme for NAD synthesis, NAMPT, and improve NAD levels. This comes of course with all the goodies of a higher NAD/NADH ration, in this case: increase in...
  10. haidut

    Niacinamide/NAD+ may prevent heart failure

    The rates of cardiovascular disease (CVD) continue to rise and the condition is still the top killer in developed countries, though it is likely that cancer will take the top spot in the next few years and CVD will move back to second place. Heart failure (HF) is one of the common outcomes of...
    • haidut
    • Thread
    • fibrosis heart failure nad niacinamide nicotinamide oxphos
    • Replies: 0
    • Forum: Scientific Studies
  11. haidut

    Niacinamide fully reverses endotoxemia and leaky gut (from ethanol)

    The study below is a true gem due to both its broadness of impact, as well as the ease and low-cost of the therapeutic intervention it studied. Chronic endotoxemia, a cause and a result of increased gut permeability (aka "leaky gut") is now known to be a major cause of virtually all chronic...
    • haidut
    • Thread
    • alcohol atp endotoxin ethanol leaky gut lps nad niacinamide nicotinamide
    • Replies: 21
    • Forum: Scientific Studies
  12. haidut

    A single, low dose niacinamide drops triglycerides by 75%

    Among the vitamin B3 analogs, niacin is perhaps the most famous for its ability to both raise "good" cholesterol (HDL) and also lower triglycerides. However, niacinamide, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are all effective precursors to NAD (as niacin is) and...
    • haidut
    • Thread
    • lipolysis nad niacinamide nicotinamide nmn triglycerides vitamin b3
    • Replies: 17
    • Forum: Scientific Studies
  13. haidut

    Cancer relies on fat as fuel due to high reductive stress

    One of the few studies out there that not only links cancer with impaired OXPHOS, but demonstrates directly the role of reductive stress (exemplified by the NAD/NADH ratio) in cancer's appetite for fats as fuel required for the cancer survival and proliferation/metastasis. It also once again...
    • haidut
    • Thread
    • cancer fat fatty acid oxidation nad nad/nadh oxphos oxygen redox
    • Replies: 11
    • Forum: Scientific Studies
  14. haidut

    Niacinamide increases ATP/NAD, lower glucose/cortisol in humans

    A great new study demonstrating for the first time in a human experiment what hundreds of animal studies had suggested in the past. Namely, that niacinamide can serve as a reliable precursor to NAD+ and by raising the NAD/NADH ratio results in improved glucose metabolism and higher ATP levels...
    • haidut
    • Thread
    • atp cortisol glucose insulin nad niacinamide nicotinamide ribose
    • Replies: 18
    • Forum: Scientific Studies
  15. haidut

    Low-dose niacinamide has striking anti-obesity effects

    It looks like the medical world has firmly set its sights on the bioenergetic wave/target, as the number of scientific papers focusing on niacinamide, NAD/NADH ratio and OXPHOS in general has been steadily climbing since 2010. That would be good news, despite the attempts of companies such as...
    • haidut
    • Thread
    • co2 nad nampt niacinamide nicotinamide obesity oxphos vitamin b3
    • Replies: 189
    • Forum: Scientific Studies
  16. haidut

    Age-related steroid deficiency may be treatable with niacinamide

    The study is actually about eye health, and the effects androgens play in it. However, the findings are not limited to the eyes and are in fact applicable for any other tissue/organ experiencing a decline in steroidogenesis with advancing age, which is basically all of them. As such, I am...
    • haidut
    • Thread
    • aging androgen dry eye eye hypogonadism meibomian nad niacinamide nicotinamide nicotinamide mononucleotide nicotinamide riboside nmn nr steroidogenesis
    • Replies: 15
    • Forum: Scientific Studies
  17. Hans

    The ultimate macronutrient (and supplement) for longevity and health aging!

    New study talking about pyruvate, NAD, synolytics, etc. Lots of cool stuff. View: https://youtu.be/YLd3INgsHhE
  18. haidut

    Alcohol Causes Liver (and Other Organ) Damage By Lowering NAD/NADH Ratio

    A neat little study, which demonstrates once again the crucial role of energy and optimal redox status in a public health issue that has now reached catastrophic proportions. Namely, alcohol-related morbidity and mortality. Those have always been an issue in any developed country but since the...
  19. Lokzo

    5-Amino-1MQ Increases Energy, Fat Loss & Strength

    What is 5-AMINO-1MQ This compound is a small, selective membrane permeable molecule that blocks the NNMT enzyme. As fat cells grow larger, they begin to overproduce an enzyme called NNMT. NNMT = Nicotinamide N-methyltransferase. This enzyme acts to slow down fat cell metabolism (fat burning)...
  20. haidut

    Vitamin B3 May Treat "incurable" Muscle Disease

    Over the last 2-3 years I have seen a dramatic increase in the number of studies and popular press articles using the keywords "controversial", "paradox", "paradigm shift", "ameliorates an incurable condition X", etc. This is just a thinly veiled attempt to mask the collapse of the corrupt dogma...
    • haidut
    • Thread
    • cure incurable myopathy nad niacin niacinamide vitamin b3
    • Replies: 12
    • Forum: Scientific Studies
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