insulin resistance

  1. P

    Obesity/insulin resistant and impared glycine synthesis

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219591/ Hypoglycinemia in participants with morbid obesity was associated with impaired de novo glycine synthesis. The increase in plasma glycine concentration and de novo glycine synthesis plus the marked improvement in insulin resistance after...
  2. D

    Any advice on these labs?

    Can this all be reversed naturally with diet? Possible suspected health issues, IR, anal fistula (might have colorectal cancer), possible testicle damage (had surgery on testicle when it became detached as infant) peating hasn't improved any health markers so far.
  3. haidut

    Lactate is a key driver of diabetes/obesity, by promoting inflammation

    A great study, demonstrating that in diabetes (just as in cancer) the so-called Warburg Effect (aerobic glycolysis) is as much a cause of those degenerative conditions as it is an effect of. The study below demonstrated that increased intracellular lactate results in robust increase in systemic...
    • haidut
    • Thread
    • acidosis diabetes inflammation insulin resistance lactate lactic acid obesity
    • Replies: 18
    • Forum: Scientific Studies
  4. Hans

    When keto diets backfire and cause health problems

    Chronically doing a very low-carb diet can lead to problems. Obviously, not everyone suffers from them, but a relatively large percentage do. Here I talk about a few of the side effects of doing a very low carb diet...
  5. haidut

    DHT better (and safer) than testosterone for improving blood pressure, insulin levels

    A great human study on the beneficial effects of androgens for a variety of metabolic biomarkers associated with insulin resistance and diabetes II. The only gripe I have with this study is that they claim it was conducted with "healthy" men when in reality all men had low plasma total...
    • haidut
    • Thread
    • dht diabetes glucose insulin insulin resistance insulin sensitivity obesity testosterone
    • Replies: 46
    • Forum: Scientific Studies
  6. Mauritio

    Low Dopamine D2 receptor density leads to obesity and insulin resistance , D2 agonism may treat

    These studies show that the Dopmine D2 receptors are strongly involved in obesity and insulin resistance . 1. (Brain dopamine and obesity - PubMed) "Striatal dopamine D2 receptor availability was significantly lower in the ten obese individuals (2.47 [SD 0.36]) than in controls (2.99 [0.41]...
  7. haidut

    Statins May Cause Insulin Resistance By Depleting Vitamin K

    A great study, which both highlights the dangers of statins while also providing a plausible mechanism for those side effects that both FDA and Big Pharma vehemently continue to dispute. This plausible mechanism involves the inhibition of vitamin K2 (MK-4) synthesis, which requires the same...
    • haidut
    • Thread
    • diabetes glucose metabolism insulin resistance mk-4 osteocalcin statins vitamin k
    • Replies: 9
    • Forum: Scientific Studies
  8. haidut

    PUFA May Drive Obesity, Insulin Resistance, Liver Issues In Diabetes II Patients

    Yet another study where the message is clear - there is nothing "essential" about the PUFA we are bombarded with from all directions be that diet, medical interventions, household products, etc. What makes this study particularly relevant is that PUFA ingestion actually is promoted as one of the...
    • haidut
    • Thread
    • diabetes fatty liver insulin resistance obesity omega-3 omega-6 promote pufa
    • Replies: 0
    • Forum: Scientific Studies
  9. Tarmander

    Gut Protocol For Insulin Resistance, Metabolism, And Energy

    I wanted to share this amazing gut protocol that I have been on for the last few months (results below) I am in a unique position as a type 1 diabetic in that my pancreas produces little to no insulin on its own. This gives me an insight into what supplements and herbs do to insulin needs in...
  10. haidut

    Vitamin D Reduces Blood Sugar And Body Fat In Obese Women

    A neat study, albeit lasting much longer (about 1.5 years) than most other intervention studied with vitamin D. What makes this study particularly interesting is that it only used high doses vitamin D (60,000 IU once weekly) initially until blood levels rose into the normal range. It did not...
    • haidut
    • Thread
    • blood glucose cholecalciferol fat loss improve insulin resistance obesity prediabetes vitamin d vitamin d3
    • Replies: 2
    • Forum: Scientific Studies
  11. haidut

    Vitamin D Strikingly Therapeutic For Type II Diabetes

    Despite the ongoing assault against "ineffective" dietary supplements, the evidence in favor of them keeps piling on. One of the favorite targets of mainstream media is vitamin D, and multiple claims of "ineffectiveness" based on "meta" studies have come out in the last 5 years. Usually, this is...
    • haidut
    • Thread
    • blood glucose cholecalciferol cvd diabetes improve insulin resistance insulin sensitivity treat vitamin d vitamin d3
    • Replies: 18
    • Forum: Scientific Studies
  12. haidut

    Burning More Fat And Less Glucose Leads To Diabetes

    I really hope the keto community and other low-carb diet afficionados are taking note of the stream of recent studies that keep demonstrating a causative link between low-carb and/or high-fat diets, fasting, chronic stress, cortisol and diabetes. The evidence at this point is indisputable, no...
    • haidut
    • Thread
    • amino acids catabolism cause cortisol diabetes fao fat fatty acid oxidation increased insulin resistance
    • Replies: 19
    • Forum: Scientific Studies
  13. haidut

    Serotonin (due To Bacteria) Is The Master Regulator Of Metabolism, Insulin Sensitivity, And Weig

    Over the last year I posted a number of studies demonstrating strong link between serotonin and chronic conditions such as obesity, insulin resistance, and even diabetes. Augmented capacity for peripheral serotonin release in human obesity...
    • haidut
    • Thread
    • 5-ht bacteria colon diabetes gut inflammation insulin resistance microbiome obesity pathological serotonin sibo tph
    • Replies: 31
    • Forum: Scientific Studies
  14. redsun

    Folic Acid, Insulin Resistance, ED, CKD

    I put together some studies on folic acid(folate) here seeing as there isn't much on it on this forum. I'd thought I'd do my part in adding something useful here. Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice. - PubMed -...
    • redsun
    • Thread
    • folic acid insulin resistance vitamin b9
    • Replies: 7
    • Forum: Vitamins
  15. haidut

    MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

    Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS - i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology...
    • haidut
    • Thread
    • ceramides fao fatty acid oxidation glucose insulin resistance lps mitochondria mitochondrial function ms multiple sclerosis randle cycle tlr tlr4
    • Replies: 48
    • Forum: Scientific Studies
  16. haidut

    Vitamin D Deficiency Can Cause Heart Failure

    As many readers know, there is an epidemic of vitamin D deficiency. It is of worldwide proportions, but is visible mainly in "developed" countries in the Western world. The official stance of mainstream medicine is that while vitamin D deficiency is undesirable, it does not really have much...
    • haidut
    • Thread
    • cardiac insufficiency cause cholecalciferol deficiency diet glucose metabolism heart failure high-fat inflammation insulin resistance vitamin d vitamin d3
    • Replies: 2
    • Forum: Scientific Studies
  17. haidut

    Fibromyalgia May Be Simply A Sign Of Insulin Resistance

    As many of your have seen on TV, there is currently a boom in ads for drigs to treat fibromyalgia. This condition is yet another one of mysterious origins, at least according to mainstream medicine. The treatment consists mainly of GABA agonists like Lyrica but the official version is (of...
    • haidut
    • Thread
    • diabetes ffa fibromyalgia insulin resistance metformin nefa neuropathy niacinamide pain symptom
    • Replies: 19
    • Forum: Scientific Studies
  18. yerrag

    Protocol For Curing Type 2 Diabetes, Anyone?

    Has anyone here ever attempted to cure type 2 diabetes successfully? A friend just started diabetes medication, and in a party we were in, he passed out because the medication made his blood sugar go way low. I told him I'll see if I can provide a method where he can get his condition cured...
    • yerrag
    • Thread
    • diabetes insulin insulin resistance iron
    • Replies: 82
    • Forum: Blood Sugar
  19. haidut

    Endotoxin Causes (liver) Steatosis, Insulin Resistance And Atherosclerosis

    I know this study was in hepatitis C patients only, but there is nothing about Hep C that would invalidate this finding in the general population too. Quite a few people on the forum reported that when they tried to talk to their doctor about endotoxin and its possible role in their health...
    • haidut
    • Thread
    • atherosclerosis cvd endotoxemia endotoxin hepatitis inflammation insulin resistance liver lps steatosis tlr4
    • Replies: 16
    • Forum: Scientific Studies
  20. haidut

    Sterilizing The Gut Restores Insulin Sensitivity By Reducing Fatty Acid Oxidation

    I am posting this study just as an example of how important the role of endotoxin is in insulin resistance and diabetes. Similarly to the human study with aspirin, sterilizing the gut with antibiotics did not reduce the weight in the obese subjects (in this case mice). So, obesity may be a less...
    • haidut
    • Thread
    • antibiotics bacteria beta oxidation colon diabetes endotoxin fatty acid oxidation ffa gut insulin resistance insulin sensitivity lps microbiome obesity sterile sterilizing
    • Replies: 71
    • Forum: Scientific Studies
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