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heart failure
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PUFA peroxidation can cause heart failure, latter can be reversed
The mainstream view on heart failure is that in most cases (when it is not congenital) it is a secondary morbidity caused by conditions such as diabetes, CVD, obesity, smoking, alcohol intake, etc. However, a direct causative agent and process has not been proposed so far. The study below...- haidut
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- aldehyde aldehyde dehydrogenase aldh androgen estrogen heart failure nad peroxidation pufa
- Replies: 0
- Forum: Scientific Studies
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Reduced availability/oxidation of glucose sufficient to cause heart failure (HF)
Yet another "mysterious" idiopathic condition turns out to be nothing but metabolic dysregulation in disguise. Also, unlike many other studies implicating metabolism in disease, this one actually manages to demonstrate that reduction of oxidative glucose metabolism is sufficient to cause severe...- haidut
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- glucose heart failure lactate ldh mitochondria oxphos pyruvate
- Replies: 1
- Forum: Scientific Studies
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Heart failure after giving birth
A friend of mine’s wife just had a baby and was diagnosed with cardiomyopathy soon after. She’s 35 years old. She had a long stay at the hospital after the birth and recently (about 6 weeks later) went back in for an ablation. She’s not vaxxed. The family actually had covid about a month...- Peachy
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- cardiomyopathy heart failure
- Replies: 13
- Forum: Ask For Help or Advice
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Niacinamide/NAD+ may prevent heart failure
The rates of cardiovascular disease (CVD) continue to rise and the condition is still the top killer in developed countries, though it is likely that cancer will take the top spot in the next few years and CVD will move back to second place. Heart failure (HF) is one of the common outcomes of...- haidut
- Thread
- fibrosis heart failure nad niacinamide nicotinamide oxphos
- Replies: 0
- Forum: Scientific Studies
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SSRI/serotonin cause heart damage/failure
The role of serotonin in fibrotic conditions is well-known in research circles but is a taboo topic in medicine. Perhaps the best example of this bipolar (and potentially criminal) attitude is the fact that Pfizer sells billions of dollars worth its SSRI drugs Zoloft and Pristiq, yet at the same...- haidut
- Thread
- 5-ht fibrosis heart damage heart failure mitral valve serotonin ssri
- Replies: 9
- Forum: Scientific Studies
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Iron drives heart failure by fattening the heart; iron chelators may prevent/cure
Recommending high intake of iron is one of the most common dietary recommendations of registered dieticians, as well as many doctors. The fact that lipofuscin - a highly insoluble complex of iron and PUFA peroxides - increases with age is conveniently ignored in those recommendations. The...- haidut
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- chelation cvd heart attack heart failure iron lipofuscin pufa vitamin e
- Replies: 43
- Forum: Scientific Studies
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NSAID drugs, except aspirin, linked to heart failure
The link between NSAID usage (except aspirin) and heart attacks is not new, but I decided to still post this study due to the fact that it is the first to suggest those non-aspirin NSAID may actually damage the heart themselves rather than cause CVD events indirectly. Notably, once again...- haidut
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- cox cvd damage heart failure inflammation nsaid prostaglandins
- Replies: 2
- Forum: Scientific Studies
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Impaired OXPHOS by high ketones drives heart failure
Just a few weeks after my post on how excessive fatty acid oxidation (FAO) drives cancer, below is another great new study, which corroborates once again the hypothesis that excessive FAO (and/or fatty acid supply into the mitochondria of the cell) result in impaired OXPHOS and organ damage...- haidut
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- fao fatty acid oxidation heart failure ketone krebs mitochondria oxphos succinate
- Replies: 4
- Forum: Scientific Studies
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P
My Gratitude... Cardiovascular Disease REVERSED.
Hello guys. December 2020, I posted about my CVD and desperately asked for help: Cardiologist Report: Thickening of My Heart Wall I carefully analyzed the comments, plus ideas gleaned from personal research and went all out to fight this deadly ailment. And... I CONQUERED May 2021: I met my...- Patty
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- cvd heart arrhythmia heart disease heart failure
- Replies: 40
- Forum: Ask For Help or Advice
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Vitamin B1 can reverse heart damage/failure caused by alcoholism
The beneficial effects of vitamin B1 (thiamine) on the nervous system have been known for a long time, and the vitamin is routinely used in hospitals around the world to treat both acute alcohol intoxication as well as the nervous system damage known as Wernicke-Korsakoff syndrome caused by...- haidut
- Thread
- alcohol alcoholism cardiomyopathy heart failure reverse thiamine vitamin b1
- Replies: 7
- Forum: Scientific Studies
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Reduced pyruvate and/or increased lactate drive heart failure
I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of...- haidut
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- energy heart failure lactate lactic acid oxphos pyruvate
- Replies: 0
- Forum: Scientific Studies
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Forcing The Heart To Burn Glucose Instead Of Fat May Cure Heart Failure
One of the blockbuster studies I have seen over the last 12 months. It reads as if written by Peat himself and discusses tissue regeneration, Randle cycle, dietary control of metabolism, etc. AFAIK this is the first study brave enough to demonstrate that simply switching fuel types in an...- haidut
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- estrogen fatty acid oxidation glucose heart failure niacinamide pdh pdk thiamine
- Replies: 27
- Forum: Scientific Studies
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PUFA (metabolites) Drive Heart Failure And Possibly Diabetes
Over the years I have posted a number of studies on the roles of PUFA metabolites such as prostaglandins and leukotrienes in many chronic conditions including cancer, Alzheimer, Parkinson, ALS, MS, CVD, etc. For those that are new to this issue, COX enzymes are responsible for prostaglandin...- haidut
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- 12/15lox alox15 cause cvd diabetes drive fibrosis heart attack heart failure inflammation lipoxygenase lox pufa
- Replies: 4
- Forum: Scientific Studies
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Vitamin D Deficiency Can Cause Heart Failure
As many readers know, there is an epidemic of vitamin D deficiency. It is of worldwide proportions, but is visible mainly in "developed" countries in the Western world. The official stance of mainstream medicine is that while vitamin D deficiency is undesirable, it does not really have much...- haidut
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- cardiac insufficiency cause cholecalciferol deficiency diet heart failure high-fat inflammation insulin resistance vitamin d vitamin d3
- Replies: 2
- Forum: Scientific Studies
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Heart Failure Deaths On The Rise In Younger US Adults
The bad news for younger Americans just keep on coming. In addition to lethal cancers, diabetes, stroke, CVD, infertility, etc now we can add yet another "old man" disease to the list of banes inflicting the "young". The "Young" Have Now Become The Old Heart failure is a condition traditionally...- haidut
- Thread
- fibrosis heart failure millenials mortality rates reversing rising trend young
- Replies: 6
- Forum: Scientific Studies
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PUFA As The Main Cause Of Cardiovascular Disease (CVD) And Organ Failure
Some more evidence on the role of PUFA as a big factor in CVD. While the evidence is not widely discussed on mainstream media, and a few saboteur attempt against coconut oil have recently been published, nonetheless a few "runaways" do make it to front page news and we have posted them on the...- haidut
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- causal cause cell death cholesteryl linoleate cvd drive factor heart arrhythmia heart attack heart disease heart failure inflammation ldl linoleic acid omega-6 organ failure pufa
- Replies: 8
- Forum: Scientific Studies
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Standing At Work May Be A Lot More Dangerous Than Sitting
I am sure many people here have seen the flood of ads for "standing desks" - a raised desk without a chair which a person uses to work in an upright position instead of sitting. Thee have been many health claims made for these desks, none of which have been verified so far in controlled studies...- haidut
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- cvd heart attack heart failure job risk sitting standing work
- Replies: 28
- Forum: Scientific Studies
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Another "obesity Paradox" - It Lowers Mortality In Patients With Atrial Fibrillation
I hope this is not taken as a call to get obese. I am posting it simply as an example that obesity may be a protective mechanism once a disease is already established. As such, it should not be viewed always in a negative light but as a possible result of an endocrine disorder, which likely...- haidut
- Thread
- atrial fibrilation cvd heart failure hypertension lower mortality obesity paradox
- Replies: 7
- Forum: Scientific Studies
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NSAID Other Than Aspirin Strongly Increase Risk Of Cardiac Arrest, Heart Failure, And Stroke
It has been know for at least 20 years that taking NSAID drugs other than aspirin increases risk of heart problems. The risk was considered low and even if materialized it was thought it would lead to relatively low grade heart attacks. However, this new study shows that the risk is higher than...- haidut
- Thread
- black box cardiac arrest diclofenac fda heart failure ibuprofen nsaid restrictions stroke
- Replies: 4
- Forum: Scientific Studies
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Proton Pump Inhibitors (PPI) Increase All-cause Mortality And Heart Failure
I posted a few studies before on the terrible side effects of PPI drugs. These drugs are perhaps the most prescribed class of drugs in the Western world for conditions like GERD, ulcers, or even to prepare for routine surgery. Recently, these drugs were approved even for use in newborns...- haidut
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- effect gerd heart failure inotropic mortality negative ppi
- Replies: 5
- Forum: Scientific Studies