Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
I've been trying to find evidence for the mechanism of action of all vitamin K forms on regenerating/helping the liver.
The MoAs mentioned on this forum are kind of vague in my opinion. I do think vitamin K can be very helpful for the liver in many ways and I think the specific MoA deserves more attention.
I know georgi mentioned something about the kupfer cells. And ray said it helps support the function of CoQ10. So that's 2 mechanisms already.
This study mentions that vitamin K2 increases the hepatic progenitor cells (oval cells in rodents) and Matrillin-2 and by this mechanism helps the liver to regenerate after partial hepatectomy.
Matrillin-2 is a protein, which "promotes neurite outgrowth, Schwann cell migration, neuromuscular junction formation, skeletal muscle and liver regeneration and skin wound healing."
(Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues - PubMed)
The effect was dose-dependant, so more K2 = more liver regeneration.
They also showed that blocking the increase of Matrillin-2 largely stopped the liver regeneration, showing that the regeneration was depending on this protein.
Unfortunately I couldn't find the full text, so I dont know which form of vitamin K2 and what dosage they used.
The MoAs mentioned on this forum are kind of vague in my opinion. I do think vitamin K can be very helpful for the liver in many ways and I think the specific MoA deserves more attention.
I know georgi mentioned something about the kupfer cells. And ray said it helps support the function of CoQ10. So that's 2 mechanisms already.
This study mentions that vitamin K2 increases the hepatic progenitor cells (oval cells in rodents) and Matrillin-2 and by this mechanism helps the liver to regenerate after partial hepatectomy.
Matrillin-2 is a protein, which "promotes neurite outgrowth, Schwann cell migration, neuromuscular junction formation, skeletal muscle and liver regeneration and skin wound healing."
(Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues - PubMed)
The effect was dose-dependant, so more K2 = more liver regeneration.
They also showed that blocking the increase of Matrillin-2 largely stopped the liver regeneration, showing that the regeneration was depending on this protein.
Unfortunately I couldn't find the full text, so I dont know which form of vitamin K2 and what dosage they used.
Vitamin K2-enhanced liver regeneration is associated with oval cell expansion and up-regulation of matrilin-2 expression in 2-AAF/PH rat model - PubMed
Normal liver has a great potential of regenerative capacity after partial hepatectomy. In clinic, however, most patients receiving partial hepatectomy are usually suffering from chronic liver diseases with severely damaged hepatocyte population. Under these conditions, activation of hepatic...
pubmed.ncbi.nlm.nih.gov