pyr0maniac
Member
- Joined
- Sep 3, 2020
- Messages
- 7
Hello everybody. Came across this study which I thought some people might find very interesting. I can't post a link to the full study being a new member but if you search google for "Retroconversion of estrogens into androgens by bacteria via a cobalamin-mediated methylation" - it should be the first link.
Abstract:
Any idea on what dosage of methylcobalamin would be needed to achieve a significant amount of retroconversion? Or is that a bad idea?
There is also a related study if you search for "Anaerobic bacteria need their vitamin B12 to digest estrogen".
Abstract:
Steroid estrogens modulate physiology and development of vertebrates. Conversion of C19 androgens into C18 estrogens is thought to be an irreversible reaction. Here, we report a denitrifying Denitratisoma sp. strain DHT3 capable of catabolizing estrogens or androgens anaerobically. Strain DHT3 genome contains a polycistronic gene cluster, emtABCD, differentially transcribed under estrogen-fed conditions and predicted to encode a cobalamin-dependent methyltransferase system conserved among estrogen-utilizing anaerobes; an emtA-disrupted DHT3 derivative could catabolize androgens but not estrogens. These data, along with the observed androgen production in estrogen-fed strain DHT3 cultures, suggested the occurrence of a cobalamin-dependent estrogen methylation to form androgens. Consistently, the estrogen conversion into androgens in strain DHT3 cell extracts requires methylcobalamin and is inhibited by propyl iodide, a specific inhibitor of cobalamin-dependent enzymes. The identification of the cobalamin-dependent estrogen methylation thus represents an unprecedented metabolic link between cobalamin and steroid metabolism and suggests that retroconversion of estrogens into androgens occurs in the biosphere.
Any idea on what dosage of methylcobalamin would be needed to achieve a significant amount of retroconversion? Or is that a bad idea?
There is also a related study if you search for "Anaerobic bacteria need their vitamin B12 to digest estrogen".
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