ddjd
Member
- Joined
- Jul 13, 2014
- Messages
- 6,738
Not my words but found this in another RP group page;
https://www.karger.com/Article/Pdf/110927
"Chronic consumption of pre-formed vitamin A may be the cause of Alzheimer's. Here is the mechanism: Vitamin A is normally transported in the body by retinol binding protein. Excess consumption of vitamin A (I'm talking amounts even smaller than the government recommendations) leads to free circulating vitamin A which is unbound to retinol binding protein. It is this free vitamin A which is toxic.
Vitamin A is a very unsaturated molecule, even more unsaturated than polyunsatured fats. Unsaturated molecules have double carbon-carbon bonds which are extremely electron rich. Two things can happen here. 1. The electron rich vitamin A donates an electron to O2. This creates superoxide, a radical species, which then goes on to create hydrogen peroxide and peroxynitrite which kill cells. 2. Heavy metals such as iron, aluminum, and copper can accept electrons from the electron rich vitamin A and then donate them to O2 to cause the same cascade. This splits the vitamin A molecule (much like polyunsaturated fats) into toxic lipid peroxide species which cause even more damage. This kills neurons in the brain, particularly in the hippocampus which is responsible for emotion and memory. It has been shown that those people who have Alzheimer's have lower levels of retinol binding protein, making vitamin A even more toxic.
Also, overdosing on vitamin A seems to suppress the production of retinol binding protein in a weird feedback loop that makes the toxicity exponentially worse the more you take. It is possible that we correctly diagnose the neurological issues seen in acute hypervitaminosis A as toxicity and incorrectly diagnose them as a degenerative condition in people who chronically ingest much smaller amounts. The same damage may be occurring but over a much longer timescale. Many foods are fortified with this stuff and it might be wise to rethink this strategy.
I will NEVER consume pre-formed vitamin A in any amount ever again whether it be from food (dairy, eggs, liver, chicken thighs) or supplements. It is much safer to get it from fruits and veggies because the body uses the beta carotene in them to make vitamin A but it only makes as much as it needs. It is impossible to overdose that way."
https://www.karger.com/Article/Pdf/110927
https://www.karger.com/Article/Pdf/110927
"Chronic consumption of pre-formed vitamin A may be the cause of Alzheimer's. Here is the mechanism: Vitamin A is normally transported in the body by retinol binding protein. Excess consumption of vitamin A (I'm talking amounts even smaller than the government recommendations) leads to free circulating vitamin A which is unbound to retinol binding protein. It is this free vitamin A which is toxic.
Vitamin A is a very unsaturated molecule, even more unsaturated than polyunsatured fats. Unsaturated molecules have double carbon-carbon bonds which are extremely electron rich. Two things can happen here. 1. The electron rich vitamin A donates an electron to O2. This creates superoxide, a radical species, which then goes on to create hydrogen peroxide and peroxynitrite which kill cells. 2. Heavy metals such as iron, aluminum, and copper can accept electrons from the electron rich vitamin A and then donate them to O2 to cause the same cascade. This splits the vitamin A molecule (much like polyunsaturated fats) into toxic lipid peroxide species which cause even more damage. This kills neurons in the brain, particularly in the hippocampus which is responsible for emotion and memory. It has been shown that those people who have Alzheimer's have lower levels of retinol binding protein, making vitamin A even more toxic.
Also, overdosing on vitamin A seems to suppress the production of retinol binding protein in a weird feedback loop that makes the toxicity exponentially worse the more you take. It is possible that we correctly diagnose the neurological issues seen in acute hypervitaminosis A as toxicity and incorrectly diagnose them as a degenerative condition in people who chronically ingest much smaller amounts. The same damage may be occurring but over a much longer timescale. Many foods are fortified with this stuff and it might be wise to rethink this strategy.
I will NEVER consume pre-formed vitamin A in any amount ever again whether it be from food (dairy, eggs, liver, chicken thighs) or supplements. It is much safer to get it from fruits and veggies because the body uses the beta carotene in them to make vitamin A but it only makes as much as it needs. It is impossible to overdose that way."
https://www.karger.com/Article/Pdf/110927