purple pill
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"HCA2 binds and thereby is activated by D-β-hydroxybutyric acid, butyric acid, and niacin (also known as nicotinic acid).β-Hydroxybutyric and butyric acids are regarded as the endogenous agents that activate HCA2. Under normal conditions, niacin's blood levels are too low to do so: it is given as a drug in high doses in order to reach levels that activate HCA2"
Niacin is an NAD+ precursor which when converted to NAD+ can alter over 500 enzymatic reactions that play key roles in regulating inflammation, mitochondrion functions, autophagy, and apoptosis
Studies, done mostly in animals and the cells taken from animals or humans, show or suggest that HCA2 functions to 1) inhibit lipolysis and 2) inhibit inflammation and thereby suppress the development of certain diseases in which inflammation contributes to their development and/or severity. These diseases include: atherosclerosis, stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, pathological pain (i.e. pain due to the abnormal activation of neurons), mastitis, hepatitis due to heavy alcohol consumption, inflammatory bowel diseases, cancer of the colon, and, possibly, psoriasis and brain damage due to heavy alcohol consumption.
HCA2 is expressed by: 1) certain cells in the immune system, e.g., neutrophils, monocytes, macrophages, dermal dendritic cells,[18] and lymphocytes;[13] 2) cells in the small intestine and colon epithelum that face the intestinal lumen;[26] 3) the skin's epithelial cells, keratinocytes, and Langerhans cells;[27] 4) brown and white adipose tissue fat cells;[28] 5) cells in the mammary gland's epithelium;[20] 6) hepatocytes; 7) multinucleated osteoclasts in bone tissues; 8) kidney podocytes;[13] and 9) cells in the nervous system, e.g., microglia cells in the brain's cerebral cortex and hippocampus,[24] cells in the eye's retinal pigment epithelium,[29][30] the astrocytes and neurons in the brain's rostral ventrolateral medulla, and the peripheral nervous system's Schwann and satellite glial cells.
So other than supplementing nicotinic acid, this receptor is also activated by fasting states and healthy gut bacteria breaking down fermentable fiber. The health benefits seem endless...I remember Abram Hoffer when asked of the health benefits of nicotinic acid he replied it would be quicker to list the things it doesn't do!!
Anyway this is just from wiki that I found interesting, it seems all the health benefits people report on fasting is due to activating this receptor and curing all matter of ailments. Haven't seen much mention of this receptor on here so thought i'd start a thread.
Niacin is an NAD+ precursor which when converted to NAD+ can alter over 500 enzymatic reactions that play key roles in regulating inflammation, mitochondrion functions, autophagy, and apoptosis
Studies, done mostly in animals and the cells taken from animals or humans, show or suggest that HCA2 functions to 1) inhibit lipolysis and 2) inhibit inflammation and thereby suppress the development of certain diseases in which inflammation contributes to their development and/or severity. These diseases include: atherosclerosis, stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, pathological pain (i.e. pain due to the abnormal activation of neurons), mastitis, hepatitis due to heavy alcohol consumption, inflammatory bowel diseases, cancer of the colon, and, possibly, psoriasis and brain damage due to heavy alcohol consumption.
HCA2 is expressed by: 1) certain cells in the immune system, e.g., neutrophils, monocytes, macrophages, dermal dendritic cells,[18] and lymphocytes;[13] 2) cells in the small intestine and colon epithelum that face the intestinal lumen;[26] 3) the skin's epithelial cells, keratinocytes, and Langerhans cells;[27] 4) brown and white adipose tissue fat cells;[28] 5) cells in the mammary gland's epithelium;[20] 6) hepatocytes; 7) multinucleated osteoclasts in bone tissues; 8) kidney podocytes;[13] and 9) cells in the nervous system, e.g., microglia cells in the brain's cerebral cortex and hippocampus,[24] cells in the eye's retinal pigment epithelium,[29][30] the astrocytes and neurons in the brain's rostral ventrolateral medulla, and the peripheral nervous system's Schwann and satellite glial cells.
So other than supplementing nicotinic acid, this receptor is also activated by fasting states and healthy gut bacteria breaking down fermentable fiber. The health benefits seem endless...I remember Abram Hoffer when asked of the health benefits of nicotinic acid he replied it would be quicker to list the things it doesn't do!!
Anyway this is just from wiki that I found interesting, it seems all the health benefits people report on fasting is due to activating this receptor and curing all matter of ailments. Haven't seen much mention of this receptor on here so thought i'd start a thread.